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Results: 91
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Dec 17, 2019
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy.
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Jan 06, 2020
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy.
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Dec 10, 2019
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
C. elegans Autophagy Biochemistry chemical biology Genetics Genomics human cells mammalian cells microRNA protein aggregation 3' Untranslated Regions Animals Autophagy Base Sequence Caenorhabditis elegans Caenorhabditis elegans Proteins GTPase-Activating Proteins HeLa Cells Humans Huntingtin Protein Interferon-beta Mice MicroRNAs Mutant Proteins Peptides Protein Aggregates RNA Messenger rab GTP-Binding Proteins rab7 GTP-Binding Proteins
Geospatial distributions reflect temperatures of linguistic features.
Quantifying the speed of linguistic change is challenging because the historical evolution of languages is sparsely documented. Consequently, traditional methods rely on phylogenetic reconstruction. Here, we propose a...
Performance of vertical drains in liquefaction mitigation under structures
Abstract: Several techniques have been developed in order to mitigate damage to buildings during and after liquefaction events. Benefits of using vertical drains have been verified by analysing their performance in the soil and...
Multireference linearized coupled cluster theory for strongly correlated systems using matrix product states.
We propose a multireference linearized coupled cluster theory using matrix product states (MPSs-LCC) which provides remarkably accurate ground-state energies, at a computational cost that has the same scaling as multireference...
Selection of Important Features for Optimizing Crop Yield Prediction
In agriculture, crop yield prediction is critical. Crop yield depends on various features including geographic, climate and biological. This research article discusses five Feature Selection (FS) algorithms namely Sequential...
Published by: IGI Global Scientific Publishing
An Empirical Analysis of the Joint Effects of Shoppers’ Goals and Attribute Display on Shoppers’ Evaluations
This article develops a decision-making framework that highlights how display of numeric attribute information (e.g., display of calorie information) and shoppers’ goals (i.e., having a diet focus vs. a taste focus) jointly...
An Empirical Analysis of the Joint Effects of Shoppers’ Goals and Attribute Display on Shoppers’ Evaluations
This article develops a decision-making framework that highlights how display of numeric attribute information (e.g., display of calorie information) and shoppers’ goals (i.e., having a diet focus vs. a taste focus) jointly...
Morphology and Topographic anatomy of Meningo-orbital foramen in North-Indian Population
Introduction- Variations can be found in every system of the body and can rarely be labeled as abnormal. Human skull is the most complex and important bony structure as it houses the most vital organ, known as Brain. Minor...
Meningo-orbital foramen Fronto-zygomatic suture orbit Superior orbital fissure osteoporosis variations
Published by: IJHS Medical Association
Morphology and Topographic anatomy of Meningo-orbital foramen in North-Indian Population
Introduction- Variations can be found in every system of the body and can rarely be labeled as abnormal. Human skull is the most complex and important bony structure as it houses the most vital organ, known as Brain. Minor...
Meningo-orbital foramen Fronto-zygomatic suture orbit Superior orbital fissure osteoporosis variations
Published by: IJHS Medical Association
An In-Depth Analysis of Smart Healthcare Monitoring Systems for Humans Based on IoT
Smart healthcare monitoring systems make use of IoT, the most recent technology. As a result, IoT incorporates one of its most critical applications, the health monitoring and control system. Within those systems, individuals...
Published by: IGI Global Scientific Publishing
Reply to "CRISPR screens are feasible in TP53 wild-type cells".
Haapaniemi et al address the issues raised by Brown et al and discuss several differences between the analyses performed by the two groups.
Big Data Challenges and Opportunities in Agriculture
This article reviews various aspects of research concerning the background and state-of-the-art of big data in agriculture. This article focuses on data generation, storage, analysis and visualization in big data. In every...
Published by: IGI Global Scientific Publishing
Combining Internally Contracted States and Matrix Product States To Perform Multireference Perturbation Theory.
We present two efficient and intruder-free methods for treating dynamic correlation on top of general multiconfiguration reference wave functions - including such as obtained by the density matrix renormalization group (DMRG)...
Integration of Multi-Class Service Paradigm With Generic Trust Mechanism for Innovation, Customization and Adaptability in MANETs
Trust-based mechanisms are widely used in wireless networks of different kinds for providing security against attack. Trust mechanism provides security from various attacks using both detective and preventive manner. This paper...
Published by: IGI Global Scientific Publishing
Equation of State of Fluid Methane from First Principles with Machine Learning Potentials.
Max Veit, Sandeep Kumar Jain, Satyanarayana Bonakala, Indranil Rudra, Detlef Hohl, Gábor Csányi
Feb 27, 2019
The predictive simulation of molecular liquids requires potential energy surface (PES) models that are not only accurate but also computationally efficient enough to handle the large systems and long time scales required for...
Soft Computing-Based Schemes for Handover Management in Future Networks
The progression to next generation networks is replete with abundant co-existing technologies. To comply with the always best connected paradigm, several vertical handover decision approaches have been proposed in literature...
Published by: IGI Global Scientific Publishing
Spintronics Based Non-Volatile MRAM for Intelligent Systems
In this paper the spintronic-based memory MRAM is presented that showed how it can replace both SRAM and DRAM and provide the high speed with great chip size. Moreover, MRAM is the nonvolatile memory that provides great...
Published by: IGI Global Scientific Publishing
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