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Results: 174
Establishment of a Bovine Herpesvirus 4 based vector expressing a secreted form of the Bovine Viral Diarrhoea Virus structural glycoprotein E2 for immunization purposes
Data-Centric UML Profile for Wireless Sensors
Modelling WSN data behaviour is relevant since it would allow to evaluate the capacity of an application for supplying the user needs, moreover, it could enable a transparent integration with different data-centric information...
Published by: IGI Global Scientific Publishing
Management Support Model for Information Technology Outsourcing
This study deals with the problem of outsourcing management, presenting a structure to support decision-making on effective information-technology outsourcing and highlighting the advantages and disadvantages that must be...
Published by: IGI Global Scientific Publishing
Healthcare and Social-Services Institutions in the Face of Radical Differences
When people at risk of discrimination on multiple grounds or experiencing identity-based oppression meet healthcare and social services, their complex life stories often result in mistrust and prejudice. The aim of this article...
Published by: Memorial University of Newfoundland
Healthcare and Social-Services Institutions in the Face of Radical Differences
When people at risk of discrimination on multiple grounds or experiencing identity-based oppression meet healthcare and social services, their complex life stories often result in mistrust and prejudice. The aim of this article...
Published by: Memorial University of Newfoundland
Information Science and Knowledge Management Maturity
The 21st century is known as the age of knowledge and informational data. This revolution in the way of managing knowledge required organizations to reinvent themselves in the search for competitive advantages. New models or...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
An Experimental Evaluation of a Teaching Approach for Statistical Process Control in Computer Courses
In organizations that are seeking a high degree of maturity, it is necessary to achieve a statistical control of software processes and to know their behavior and operational performance. The approach adopted for the research...
Published by: IGI Global Scientific Publishing
Label-Free Ultrasensitive Memristive Aptasensor
Ioulia Tzouvadaki, Pawan Jolly, Xiaoling Lu, Sven Ingebrandt, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Jul 13, 2016
We present the very first worldwide ever-reported electrochemical biosensor based on a memristive effect and DNA aptamers. This novel device is developed to propose a completely new approach in cancer diagnostics. In this study...
Modelling the evolution of novelty
Evolution has been an inventive process since its inception, about 4 billion years ago. It has generated an astounding diversity of novel mechanisms and structures for adaptation to the environment, for competition and...
Electrochemical biosensors and nanobiosensors
Electrochemical techniques have great promise for low-cost, miniaturised, easy-to-use, portable devices for a wide range of applications – in particular medical diagnosis and environmental monitoring. Different techniques can be...
Aptamer-based Field-Effect Biosensor for Tenofovir Detection
Nima Aliakbarinodehi, Pawan Jolly, Nikhil Bhalla, Anna Miodek, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Mar 15, 2017
During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address the lack of a reliable point-of-care drug...
Electrochemical biosensors and nanobiosensors
Electrochemical techniques have great promise for low-cost, miniaturised, easy-to-use, portable devices for a wide range of applications – in particular medical diagnosis and environmental monitoring. Different techniques can be...
Label-Free Ultrasensitive Memristive Aptasensor
Ioulia Tzouvadaki, Pawan Jolly, Xiaoling Lu, Sven Ingebrandt, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Jul 13, 2016
We present the very first worldwide ever-reported electrochemical biosensor based on a memristive effect and DNA aptamers. This novel device is developed to propose a completely new approach in cancer diagnostics. In this study...
Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
DNA replication depends on primase, the specialised polymerase responsible for synthesis of the RNA primers that are elongated by the replicative DNA polymerases. In eukaryotic and archaeal replication, primase is a heterodimer...
Aptamer-based Field-Effect Biosensor for Tenofovir Detection
Nima Aliakbarinodehi, Pawan Jolly, Nikhil Bhalla, Anna Miodek, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Mar 15, 2017
During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address the lack of a reliable point-of-care drug...
A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data.
Gennaro Gambardella, Ivana Peluso, Sandro Montefusco, Mukesh Bansal, Diego L Medina, Neil Lawrence, Diego di Bernardo
Jan 14, 2020
BACKGROUND: Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and...
Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Sandro Holzer, Neil J Rzechorzek, Isobel R Short, Michael Jenkyn-Bedford, Luca Pellegrini, Mairi L Kilkenny
Oct 17, 2019
Variant-specific vulnerability in metabolic connectivity and resting-state networks in behavioural variant of frontotemporal dementia.
Maura Malpetti, Giulia Carli, Arianna Sala, Chiara Cerami, Alessandra Marcone, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Jul 10, 2020
Brain connectivity measures represent candidate biomarkers of neuronal dysfunction in neurodegenerative diseases. Previous findings suggest that the behavioural variant of frontotemporal dementia (bvFTD) and its variants (i.e....
Behavioural variant of frontotemporal dementia Brain metabolic connectivity Fluorine-18-flourodeoxiglucose positron emission tomography Aged Attention Brain Brain Mapping Cognition Connectome Female frontotemporal dementia Humans Male Memory Middle Aged Nerve Net Neuropsychological Tests Positron-Emission Tomography
Evolution of genome fragility enables microbial division of labor.
Enrico Sandro Colizzi, Bram van Dijk, Roeland MH Merks, Daniel E Rozen, Renske MA Vroomans
Feb 02, 2023
Division of labor can evolve when social groups benefit from the functional specialization of its members. Recently, a novel means of coordinating the division of labor was found in the antibiotic-producing bacterium...
Short inverted repeats contribute to localized mutability in human somatic cells.
Xueqing Zou, Sandro Morganella, Dominik Glodzik, Helen Davies, Yilin Li, Michael R Stratton, Serena Nik-Zainal
Sep 05, 2018
Selected repetitive sequences termed short inverted repeats (SIRs) have the propensity to form secondary DNA structures called hairpins. SIRs comprise palindromic arm sequences separated by short spacer sequences that form the...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Sep 25, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Aug 06, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
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