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Results: 452
AH Welcomes New Editor
Sean McGrath
Apr 21, 2021
It is my pleasure to introduce AH12, The Phenomenology of Ludwig Landgrebe,guest edited by Sylvain Camilleri. This thorough and scholarly study will be formany an introduction to the important work of Landgrebe, who was...
Published by: Memorial University of Newfoundland
A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER+/HER2- Advanced Breast Cancer.
Erika P Hamilton, Manish R Patel, Anne C Armstrong, Richard D Baird, Komal Jhaveri, Matthias Hoch, Teresa Klinowska, Justin PO Lindemann, Shethah R Morgan, Gaia Schiavon, Hazel M Weir, Seock-Ah Im
Jul 27, 2018
Purpose: AZD9496 is an oral nonsteroidal, small-molecule inhibitor of estrogen receptor alpha (ERα) and a potent and selective antagonist and degrader of ERα. This first-in-human phase I study determined the safety and...
Adult Aged Aged 80 and over Biomarkers Tumor Breast Neoplasms Cinnamates Dose-Response Relationship Drug Drug-Related Side Effects and Adverse Reactions Estrogen Receptor alpha Female Humans Indoles Maximum Tolerated Dose Middle Aged Nausea Protein Kinase Inhibitors Receptor ErbB-2 Selective Estrogen Receptor Modulators
AH Welcomes New Editor
Sean McGrath
Apr 21, 2021
It is my pleasure to introduce AH12, The Phenomenology of Ludwig Landgrebe,guest edited by Sylvain Camilleri. This thorough and scholarly study will be formany an introduction to the important work of Landgrebe, who was...
Published by: Memorial University of Newfoundland
Weitere Beobachtungen Über den Einfluss der Befruchtung und der Zahl der Zellkeme auf die Saurebildung im Ei
Jacques Loeb
Jan 01, 0001
Jacques Loeb. Weitere Beobachtungen Über den Einfluss der Befruchtung und der Zahl der Zellkeme auf die Saurebildung im Ei
Reprinted from Biochem. Z., vol.2 (1906): 34-42
Published by: Rockefeller University
Regional structures of feeling? A spatially and socially differentiated analysis of UK student im/mobility
This article explores the patterning of student im/mobility internally within the United Kingdom, using exceptionally detailed student records data on full-time undergraduate entrants from 2014. For this cohort of students...
Regional structures of feeling? A spatially and socially differentiated analysis of UK student im/mobility
This article explores the patterning of student im/mobility internally within the United Kingdom, using exceptionally detailed student records data on full-time undergraduate entrants from 2014. For this cohort of students...
Effects of noise on integration of acoustic and electric hearing within and across ears.
In bimodal listening, cochlear implant (CI) users combine electric hearing (EH) in one ear and acoustic hearing (AH) in the other ear. In electric-acoustic stimulation (EAS), CI users combine EH and AH in the same ear. In quiet...
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers
Costanza Paoletti, Gaia Schiavon, Emily M Dolce, Elizabeth P Darga, T Hedley Carr, Joseph Geradts, Matthias Hoch, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Shethah Morgan, Parul Patel, Vicky Rowlands, Nitharsan Sathiyayogan, Kimberly Aung, Erika Hamilton, Manish Patel, Anne Armstrong, Komal Jhaveri, Seock-Ah Im, Nadia Iqbal, Fouziah Butt, Caroline Dive, Elizabeth A Harrington, J Carl Barrett, Richard Baird, Daniel F Hayes
Nov 16, 2018
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive metastatic breast cancers include, among others, ER loss and acquired activating mutations in the ligand-binding domain of the ER...
Effects of noise on integration of acoustic and electric hearing within and across ears
In bimodal listening, cochlear implant (CI) users combine electric hearing (EH) in one ear and acoustic hearing (AH) in the other ear. In electric-acoustic stimulation (EAS), CI users combine EH and AH in the same ear. In quiet...
Local asymptotic power of the Im-Pesaran-Shin panel unit root test and the impact of initial observations
In this note we derive the local asymptotic power function of the standardized averaged Dickey–Fuller panel unit root statistic of Im, Pesaran, and Shin (2003, Journal of Econometrics, 115, 53–74), allowing for heterogeneous...
Local asymptotic power of the Im-Pesaran-Shin panel unit root test and the impact of initial observations
In this note we derive the local asymptotic power function of the standardized averaged Dickey–Fuller panel unit root statistic of Im, Pesaran, and Shin (2003, Journal of Econometrics, 115, 53–74), allowing for heterogeneous...
Grammatical Relations, Transitivity and Ergativity
Cheng Luo
Sep 05, 2013
Keenan and Comrie's Accessibility Hierarchy (AH) applied to clefting predicts greater c1eftability of subject (s U) than direct object (DO). However, in some Eastern Austronesian languages, particularly Tongan, some transitive...
Published by: Atlantic Provinces Linguistic Association
Woher kommt die Hyle? Eine Analyse zur Landgrebeschen Antwort
Ying-Chien Yang
Apr 22, 2021
In der vorliegenden Arbeit befasse ich mich mit der Problematik derEmpfindung, bzw. der Hyle, in Husserls Phänomenologie und derentsprechenden Auslegung von Ludwig Landgrebe. Husserl verwendet denBegriff der Empfindung, bzw. der...
Published by: Memorial University of Newfoundland
Ascorbate oxidation by iron, copper and reactive oxygen species
Jiaqi Shen, Paul T Griffiths, Steven J Campbell, Battist Utinger, Markus Kalberer, Suzanne E Paulson
May 24, 2021
Ascorbic acid is among the most abundant antioxidants in the lung, where it likely plays a key role in the mechanism by which particulate air pollution initiates a biological response. Because ascorbic acid is a highly redox...
Evaluating parameters affecting drug fate at the intramuscular injection site
Intramuscular (IM) injections are a well-established method of delivering a variety of therapeutics formulated for parenteral administration. While the wide range of commercial IM pharmaceuticals provide a wealth of...
Outdoor PM2.5 concentration and rate of change in COVID-19 infection in provincial capital cities in China.
Yang Han, Jacqueline CK Lam, Victor OK Li, Jon Crowcroft, Jinqi Fu, Jocelyn Downey, Illana Gozes, Qi Zhang, Shanshan Wang, Zafar Gilani
Dec 15, 2021
This study investigates thoroughly whether acute exposure to outdoor PM2.5 concentration, P, modifies the rate of change in the daily number of COVID-19 infections (R) across 18 high infection provincial capitals in China...
Evaluating parameters affecting drug fate at the intramuscular injection site
Intramuscular (IM) injections are a well-established method of delivering a variety of therapeutics formulated for parenteral administration. While the wide range of commercial IM pharmaceuticals provide a wealth of...
Recycling thermal insulation materials
The limits to linear models of production based on material extraction, manufacture, use, and disposal are becoming increasingly apparent across the global economy. The Circular Economy (CE) describes an alternative to...
Woher kommt die Hyle? Eine Analyse zur Landgrebeschen Antwort
Ying-Chien Yang
Apr 22, 2021
In der vorliegenden Arbeit befasse ich mich mit der Problematik derEmpfindung, bzw. der Hyle, in Husserls Phänomenologie und derentsprechenden Auslegung von Ludwig Landgrebe. Husserl verwendet denBegriff der Empfindung, bzw. der...
Published by: Memorial University of Newfoundland
Safety, tolerability, and immunogenicity of influenza vaccination with a high-density microarray patch
Angus H Forster, Katey Witham, Alexandra CI Depelsenaire, Margaret Veitch, James W Wells, Adam Wheatley, Melinda Pryor, Jason D Lickliter, Barbara Francis, Steve Rockman, Jesse Bodle, Peter Treasure, Julian Hickling, Germain JP Fernando
Apr 14, 2020
BACKGROUND: The Vaxxas high-density microarray patch (HD-MAP) consists of a high density of microprojections coated with vaccine for delivery into the skin. Microarray patches (MAPs) offer the possibility of improved vaccine...
Administration Cutaneous Adolescent Adult Antibodies Viral Australia Cells Cultured Drug Stability Female Humans Immunogenicity Vaccine Immunoglobulin A Influenza A virus H1N1 Subtype Influenza Vaccines Influenza Human Injections Intramuscular Male Saliva T-Lymphocytes Time Factors Transdermal Patch Treatment Outcome Vaccination Young Adult
Grammatical Relations, Transitivity and Ergativity
Cheng Luo
Sep 05, 2013
Keenan and Comrie's Accessibility Hierarchy (AH) applied to clefting predicts greater c1eftability of subject (s U) than direct object (DO). However, in some Eastern Austronesian languages, particularly Tongan, some transitive...
Published by: Atlantic Provinces Linguistic Association
Impression management and achievement motivation
Andrew J. Elliot, Nawal Aldhobaiban, Kou Murayama, Ahmed Kobeisy, Małgorzata A. Gocłowska, Aber Khyat
Feb 01, 2018
In this research, we investigate impression management (IM) as a substantive personality variable by linking it to differentiated achievement motivation constructs, namely achievement motives (workmastery, competitiveness...
Reconceptualizing international mindedness in and for a posthuman world
This article offers a novel foray into International Mindedness and posthuman theory. International Mindedness (IM) underpins the International Baccalaureate’s aim to achieve a better and more peaceful world. However, in a...
Ascorbate oxidation by iron, copper and reactive oxygen species
Jiaqi Shen, Paul T. Griffiths, Steven J. Campbell, Battist Utinger, Markus Kalberer, Suzanne E. Paulson
Apr 01, 2021
Abstract: Ascorbic acid is among the most abundant antioxidants in the lung, where it likely plays a key role in the mechanism by which particulate air pollution initiates a biological response. Because ascorbic acid is a highly...
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