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3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.
Hassan Rashidi, Nguyet-Thin Luu, Salamah M Alwahsh, Maaria Ginai, Sharmin Alhaque, Hua Dong, Rute A Tomaz, Bertrand Vernay, Vasanthy Vigneswara, John M Hallett, Anil Chandrashekran, Anil Dhawan, Ludovic Vallier, Mark Bradley, Anthony Callanan, Stuart J Forbes, Philip N Newsome, David C Hay
Nov 15, 2018
Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver...
Implantable liver graft Interdisciplinary Research Liver tissue pluripotent stem cell Stable cell phenotype Animals Cell Culture Techniques Cell Differentiation Endoderm Female Hepatectomy Humans Liver Liver Transplantation Male Mice Inbred C57BL Mice Knockout Pluripotent Stem Cells Spheroids Cellular Time Factors Tissue Engineering Tissue Scaffolds
Achieving the Sustainable Development Goals Through Corporate Sustainability in a Private Banking Organization
Corporate sustainability (CS) has drawn the attention of academics and practitioners as a way to achieve profitable businesses without negatively impacting society. However, financial business organizations have not adequately...
Published by: IGI Global Scientific Publishing
Factors associated with inappropriate prescribing among older adults with complex care needs who have undergone the interRAI assessment
Aim To identify factors associated with prescribing potentially inappropriate medications (PIMs) in older adults (≥ 65 years) with complex care needs, who have undertaken a comprehensive geriatric risk...
Determinants of prescribing potentially inappropriate medications in a nationwide cohort of community dwellers with dementia receiving a comprehensive geriatric assessment
Objective: To identify the prevalence and predictors of prescribing potentially inappropriate medications (PIMs) in a nationwide cohort of community dwellers with dementia requiring complex care needs. Methods: A...
Dementia InterRAI potentially inappropriate medications prescribing in older adults /dk/atira/pure/subjectarea/asjc/2700/2717 name=Geriatrics and Gerontology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Factors associated with inappropriate prescribing among older adults with complex care needs who have undergone the interRAI assessment
Aim To identify factors associated with prescribing potentially inappropriate medications (PIMs) in older adults (≥ 65 years) with complex care needs, who have undertaken a comprehensive geriatric risk...
Revolutionizing Agriculture Through Digital Twins
The rise of digital twin (DT) technology is transforming the way businesses operate, with its applications and use cases expanding across various industries. This article focuses on the agriculture industry and explores how DT...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
The effect of MgO/TiO2 on structural and crystallization behavior of near invert phosphate-based glasses
Varying formulations in the glass system of 40P2 O5 ─(24 - x)MgO─(16 + x)CaO─(20 - y)Na2 O─yTiO2 (where 0 ≤ x ≤ 22 and y = 0 or 1) were prepared via melt-quenching. The structure of the glasses was confirmed by X-ray diffraction...
Determinants of prescribing potentially inappropriate medications in a nationwide cohort of community dwellers with dementia receiving a comprehensive geriatric assessment
Objective: To identify the prevalence and predictors of prescribing potentially inappropriate medications (PIMs) in a nationwide cohort of community dwellers with dementia requiring complex care needs. Methods: A...
Dementia InterRAI potentially inappropriate medications prescribing in older adults /dk/atira/pure/subjectarea/asjc/2700/2717 name=Geriatrics and Gerontology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Social inequality and the syndemic of chronic disease and COVID-19
Nazrul Islam, Ben Lacey, Sharmin Shabnam, A Mesut Erzurumluoglu, Hajira Dambha-Miller, Gerardo Chowell, Ichiro Kawachi, Michael Marmot
Jan 08, 2021
BACKGROUND: Given the effect of chronic diseases on risk of severe COVID-19 infection, the present pandemic may have a particularly profound impact on socially disadvantaged counties. METHODS: Counties in the USA were...
The effect of MgO/TiO2 on structural and crystallization behavior of near invert phosphate-based glasses
Varying formulations in the glass system of 40P2 O5 ─(24 - x)MgO─(16 + x)CaO─(20 - y)Na2 O─yTiO2 (where 0 ≤ x ≤ 22 and y = 0 or 1) were prepared via melt-quenching. The structure of the glasses was confirmed by X-ray diffraction...
Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
Ozayra Sharmin, Ariful Haque Abir, Abdullah Potol, Mahabub Alam, Jewel Banik, AFM Towheedur Rahman, Nuzhat Tarannum, Rasiqh Wadud, Zaki Farhad Habib, Mahbubur Rahman
Jun 10, 2021
Pamoic acid is a potent ligand for G protein Coupled Receptor 35 (GPR35) and exhibits antinociceptive property. GPR35 activation leads to increased energy utilization and the expression of anti-inflammatory genes. However, its...
COVID-19 and climatic factors
Nazrul Islam, Qasim Bukhari, Yusuf Jameel, Sharmin Shabnam, A Mesut Erzurumluoglu, Muhammad A Siddique, Joseph M Massaro, Ralph B D'Agostino
Jan 18, 2021
BACKGROUND: It is unknown if COVID-19 will exhibit seasonal pattern as other diseases e.g., seasonal influenza. Similarly, some environmental factors (e.g., temperature, humidity) have been shown to be associated with...
Physical distancing interventions and incidence of coronavirus disease 2019
Nazrul Islam, Stephen J Sharp, Gerardo Chowell, Sharmin Shabnam, Ichiro Kawachi, Ben Lacey, Joseph M Massaro, Ralph B D’Agostino, Martin White
Jul 17, 2020
Abstract: Objective: To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. Design: Natural experiment using interrupted time series analysis, with...
High quality reference genomes for toxigenic and non-toxigenic Vibrio cholerae serogroup O139.
Matthew J Dorman, Daryl Domman, Muhammad Ikhtear Uddin, Salma Sharmin, Mokibul Hassan Afrad, Yasmin Ara Begum, Firdausi Qadri, Nicholas R Thomson
Jun 20, 2019
Toxigenic Vibrio cholerae of the O139 serogroup have been responsible for several large cholera epidemics in South Asia, and continue to be of clinical and historical significance today. This serogroup was initially feared to...
Crime Detection and Criminal Recognition to Intervene in Interpersonal Violence Using Deep Convolutional Neural Network With Transfer Learning
Mohammad Haque, Rubaiya Hafiz, Alauddin Al Azad, Yeasir Adnan, Sharmin Mishu, Amina Khatun, Mohammad Uddin
Aug 12, 2022
Interpersonal violence, such as physical and sexual abuse, eve-teasing, bullying, and taking hostages, is a growing concern in our society. The criminals who directly or indirectly committed the crime often do not go into the...
Human Behavior & Psychology Social Sciences and Humanities Sociology Security and Forensics Government and Law
Published by: IGI Global Scientific Publishing
Physical distancing interventions and incidence of coronavirus disease 2019
Nazrul Islam, Stephen J Sharp, Gerardo Chowell, Sharmin Shabnam, Ichiro Kawachi, Ben Lacey, Joseph M Massaro, Ralph B D'Agostino, Martin White
Jul 28, 2020
OBJECTIVE: To evaluate the association between physical distancing interventions and incidence of coronavirus disease 2019 (covid-19) globally. DESIGN: Natural experiment using interrupted time series analysis, with results...
Vibrio cholerae Serogroup O139
Fahima Chowdhury, Alison E Mather, Yasmin Ara Begum, Muhammad Asaduzzaman, Nabilah Baby, Salma Sharmin, Rajib Biswas, Muhammad Ikhtear Uddin, Regina C LaRocque, Jason B Harris, Stephen B Calderwood, Edward T Ryan, John D Clemens, Nicholas R Thomson, Firdausi Qadri
Nov 16, 2015
Crime Detection and Criminal Recognition to Intervene in Interpersonal Violence Using Deep Convolutional Neural Network With Transfer Learning
Mohammad Haque, Rubaiya Hafiz, Alauddin Al Azad, Yeasir Adnan, Sharmin Mishu, Amina Khatun, Mohammad Uddin
Oct 01, 2021
Interpersonal violence, such as physical and sexual abuse, eve-teasing, bullying, and taking hostages, is a growing concern in our society. The criminals who directly or indirectly committed the crime often do not go into the...
Published by: IGI Global Scientific Publishing
Genomics, social media and mobile phone data enable mapping of SARS-CoV-2 lineages to inform health policy in Bangladesh
Lauren A. Cowley, Mokibul Hassan Afrad, Sadia Isfat Ara Rahman, Md Mahfuz Al Mamun, Taylor Chin, Ayesha Mahmud, Mohammed Ziaur Rahman, Mallick Masum Billah, Manjur Hossain Khan, Sharmin Sultana, Tilovatul Khondaker, Stephen Baker, Nandita Banik, Ahmed Nawsher Alam, Kaiissar Mannoor, Sayera Banu, Anir Chowdhury, Meerjady Sabrina Flora, Nicholas R. Thomson, Caroline O. Buckee, Firdausi Qadri, Tahmina Shirin
Oct 01, 2021
Genomics, social media and mobile phone data enable mapping of SARS-CoV-2 lineages to inform health policy in Bangladesh.
Lauren A Cowley, Mokibul Hassan Afrad, Sadia Isfat Ara Rahman, Md Mahfuz Al Mamun, Taylor Chin, Ayesha Mahmud, Mohammed Ziaur Rahman, Mallick Masum Billah, Manjur Hossain Khan, Sharmin Sultana, Tilovatul Khondaker, Stephen Baker, Nandita Banik, Ahmed Nawsher Alam, Kaiissar Mannoor, Sayera Banu, Anir Chowdhury, Meerjady Sabrina Flora, Nicholas R Thomson, Caroline O Buckee, Firdausi Qadri, Tahmina Shirin
Oct 27, 2021
Genomics, combined with population mobility data, used to map importation and spatial spread of SARS-CoV-2 in high-income countries has enabled the implementation of local control measures. Here, to track the spread of...
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
Elza C de Bruin, Nicholas McGranahan, Richard Mitter, Max Salm, David C Wedge, Lucy Yates, Mariam Jamal-Hanjani, Seema Shafi, Nirupa Murugaesu, Andrew J Rowan, Eva Grönroos, Madiha A Muhammad, Stuart Horswell, Marco Gerlinger, Ignacio Varela, David Jones, John Marshall, Thierry Voet, Peter Van Loo, Doris M Rassl, Robert C Rintoul, Sam M Janes, Siow-Ming Lee, Martin Forster, Tanya Ahmad, David Lawrence, Mary Falzon, Arrigo Capitanio, Timothy T Harkins, Clarence C Lee, Warren Tom, Enock Teefe, Shann-Ching Chen, Sharmin Begum, Adam Rabinowitz, Benjamin Phillimore, Bradley Spencer-Dene, Gordon Stamp, Zoltan Szallasi, Nik Matthews, Aengus Stewart, Peter Campbell, Charles Swanton
May 08, 2019
Spatial and temporal dissection of the genomic changes occurring during the evolution of human non-small cell lung cancer (NSCLC) may help elucidate the basis for its dismal prognosis. We sequenced 25 spatially distinct regions...
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers, Tim O'Brien, Jose I Lopez, Thomas BK Watkins, David Nicol, Mark Stares, Ben Challacombe, Steve Hazell, Ashish Chandra, Thomas J Mitchell, Lewis Au, Claudia Eichler-Jonsson, Faiz Jabbar, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Aengus Stewart, Wei Xing, Jonathan C Smith, Mickael Escudero, Adam Huffman, Nik Matthews, Greg Elgar, Ben Phillimore, Marta Costa, Sharmin Begum, Sophia Ward, Max Salm, Stefan Boeing, Rosalie Fisher, Lavinia Spain, Carolina Navas, Eva Grönroos, Sebastijan Hobor, Sarkhara Sharma, Ismaeel Aurangzeb, Sharanpreet Lall, Alexander Polson, Mary Varia, Catherine Horsfield, Nicos Fotiadis, Lisa Pickering, Roland F Schwarz, Bruno Silva, Javier Herrero, Nick M Luscombe, Mariam Jamal-Hanjani, Rachel Rosenthal, Nicolai J Birkbak, Gareth A Wilson, Orsolya Pipek, Dezso Ribli, Marcin Krzystanek, Istvan Csabai, Zoltan Szallasi, Martin Gore, Nicholas McGranahan, Peter Van Loo, Peter Campbell, James Larkin, Charles Swanton, TRACERx Renal Consortium
Jul 17, 2018
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study...
branched evolution Cancer evolution chromosome instability deterministic evolution intratumor heterogeneity linear evolution metastasis punctuated evolution renal cell cancer tumor diversity Adult Aged Aged 80 and over Alleles Biomarkers Tumor Carcinoma Renal Cell Chromosomes Clonal Evolution Disease Progression evolution Molecular Female Genetic Heterogeneity genetic variation Humans Kidney Neoplasms Longitudinal Studies Male Middle Aged Models Statistical Mutation Neoplasm Metastasis Phenotype Phylogeny Prognosis Prospective Studies Sequence Analysis DNA