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Results: 40
Investigating the Relationship between Home Parenteral Support and Needs-Based Quality of Life in Patients with Chronic Intestinal Failure
Debra Jones, Simon Lal, Chloe French, Anne Marie Sowerbutts, Matthew Gittins, Simon Gabe, Diane Brundrett, Alison Culkin, Chris Calvert, Beth Thompson, Sheldon C Cooper, Jane Fletcher, Clare Donnellan, Alastair Forbes, Ching Lam, Shellie Radford, Christopher G Mountford, Daniel Rogers, Rebecca Muggridge, Lisa Sharkey, Penny Neild, Carolyn Wheatley, Philip Stevens, Sorrel Burden
Feb 03, 2023
Mind Games: Big South Quiz Bowl Set for Jan. 28
Winthrop University
Jan 01, 0001
The competition will get underway at 9 a.m. as each college team will face each other during the seven rounds held in Owens Hall. Competing are Winthrop, Gardner-Webb, Radford, Liberty, Coastal Carolina, Virginia Military...
Published by: Winthrop University
Dominant male song performance reflects current immune state in a cooperatively breeding songbird.
Conspicuous displays are thought to have evolved as signals of individual "quality", though precisely what they encode remains a focus of debate. While high quality signals may be produced by high quality individuals due to...
Retiring President Inducted into Big South Hall of Fame For His Contributions
Winthrop University
Jan 01, 0001
Dr. DiGiorgio was inducted along with former Liberty volleyball record holder Anthonia Akpama and Radford men's soccer standout Ian Spooner. The Class of 2013 inductees increases the Big South Conference Hall of Fame to 52...
Published by: Winthrop University
Prions
Neurodegenerative diseases are characterized by the aggregation of misfolded proteins in the brain. Among these disorders are the prion diseases, which are transmissible, and in which the misfolded proteins ("prions") are also...
Alzheimer Disease Alzheimer's gene therapy neurodegeneration Neuroprotection Prion Unfolded Protein Response (UPR) adenine Alzheimer Disease Amyloid beta-Peptides Animals Humans Indoles Neurodegenerative Diseases Parkinson Disease Prion Diseases Prions Protein Conformation Protein Kinase Inhibitors Tauopathies Unfolded Protein Response ALPHA-SYNUCLEIN eIF-2 Kinase tau Proteins
DiGiorgio Among 2013 Big South Conference Inductees Into Hall of Fame
Winthrop University
Jan 01, 0001
Winthrop President Anthony DiGiorgio, along with former Liberty volleyball player Anthonia Akpama and former Radford men's soccer player Ian Spooner, will be officially installed on Thursday, May 30, during a special ceremony as...
Published by: Winthrop University
Exposure of benthic invertebrates to sediment vibration
Louise Roberts, Harry R. Harding, Irene Voellmy, Rick Bruintjes, Stephen D. Simpson, Andrew N. Radford, Thomas Breithaupt, Michael Elliott
Oct 01, 2016
Activities directly interacting with the seabed, such as pile-driving, can produce vibrations that have the potential to impact benthic invertebrates within their vicinity. This stimuli may interfere with crucial behaviors...
Exposure of benthic invertebrates to sediment vibration
Louise Roberts, Harry R. Harding, Irene Voellmy, Rick Bruintjes, Stephen D. Simpson, Andrew N. Radford, Thomas Breithaupt, Michael Elliott
Oct 01, 2016
Activities directly interacting with the seabed, such as pile-driving, can produce vibrations that have the potential to impact benthic invertebrates within their vicinity. This stimuli may interfere with crucial behaviors...
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Mark Halliday, Helois Radford, Karlijn AM Zents, Collin Molloy, Julie A Moreno, Nicholas C Verity, Ewan Smith, Catharine A Ortori, David A Barrett, Martin Bushell, Giovanna R Mallucci
Nov 16, 2017
See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article.Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis...
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A Moreno, Joern R Steinert, Tim Smith, David Dinsdale, Anne E Willis, Giovanna R Mallucci
Nov 09, 2017
In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity. Reduction in synapse number is a consistent early feature of neurodegenerative...
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.
Sacri R Ferrón, Marika Charalambous, Elizabeth Radford, Kirsten McEwen, Hendrik Wildner, Eleanor Hind, Jose Manuel Morante-Redolat, Jorge Laborda, Francois Guillemot, Steven R Bauer, Isabel Fariñas, Anne C Ferguson-Smith
Apr 09, 2019
The gene for the atypical NOTCH ligand delta-like homologue 1 (Dlk1) encodes membrane-bound and secreted isoforms that function in several developmental processes in vitro and in vivo. Dlk1, a member of a cluster of imprinted...
aging Animals Animals Newborn Astrocytes Base Sequence Calcium-Binding Proteins Cell Membrane Cells Cultured Embryo Mammalian Female Genomic Imprinting Genotype Intercellular Signaling Peptides and Proteins Male Mice Mice Inbred C57BL Neural Stem Cells Neurogenesis Olfactory Bulb Protein Isoforms Stem Cell Niche
Protocol for the melatools skin self-monitoring trial
Katie Mills, Jon Emery, Rebecca Lantaff, Michael Radford, Merel Pannebakker, Per Hall, Nigel Burrows, Kate Williams, Catherine L Saunders, Peter Murchie, Fiona M Walter
Jan 30, 2018
An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.
Elizabeth J Radford, Elvira Isganaitis, Josep Jimenez-Chillaron, Joshua Schroeder, Michael Molla, Simon Andrews, Nathalie Didier, Marika Charalambous, Kirsten McEwen, Giovanna Marazzi, David Sassoon, Mary-Elizabeth Patti, Anne C Ferguson-Smith
Dec 02, 2020
Environmental factors during early life are critical for the later metabolic health of the individual and of future progeny. In our obesogenic environment, it is of great socioeconomic importance to investigate the mechanisms...
DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.
Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B Pinnock, Sacri R Ferrón, Antonio Vidal-Puig, Anne C Ferguson-Smith
Nov 13, 2014
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma
Franck Morschhauser, Martin J. S. Dyer, Harriet S. Walter, Alexey V. Danilov, Loic Ysebaert, Daniel James Hodson, Christopher Fegan, Simon A. Rule, John Radford, Guillaume Cartron, Krimo Bouabdallah, Andrew John Davies, Stephen Spurgeon, Nishanthan Rajakumaraswamy, Biao Li, Rita Humeniuk, Xi Huang, Pankaj Bhargava, Juliane M. Jürgensmeier, Gilles Salles
Jul 07, 2021
Funder: Gilead Sciences (Gilead); doi: https://doi.org/10.13039/100005564
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma.
Franck Morschhauser, Martin JS Dyer, Harriet S Walter, Alexey V Danilov, Loic Ysebaert, Daniel James Hodson, Christopher Fegan, Simon A Rule, John Radford, Guillaume Cartron, Krimo Bouabdallah, Andrew John Davies, Stephen Spurgeon, Nishanthan Rajakumaraswamy, Biao Li, Rita Humeniuk, Xi Huang, Pankaj Bhargava, Juliane M Jürgensmeier, Gilles Salles
Dec 04, 2020
B-cell receptor (BCR) signaling pathway inhibitors (including Bruton’s tyrosine kinase [BTK] inhibitors, and phosphatidylinositol-3 kinase inhibitors [PI3Ki]) have shown clinical efficacy in non-Hodgkin lymphoma (NHL). However...
Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
Goran Lakisic, Alice Lebreton, Renaud Pourpre, Olivia Wendling, Emanuele Libertini, Elizabeth J Radford, Morwenna Le Guillou, Marie-France Champy, Marie Wattenhofer-Donzé, Guillaume Soubigou, Slimane Ait-Si-Ali, Jean Feunteun, Tania Sorg, Jean-Yves Coppée, Anne C Ferguson-Smith, Pascale Cossart, Hélène Bierne
Dec 02, 2020
BAHD1 is a vertebrate protein that promotes heterochromatin formation and gene repression in association with several epigenetic regulators. However, its physiological roles remain unknown. Here, we demonstrate that ablation of...
AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment
Gareth O Griffiths, Richard FitzGerald, Thomas Jaki, Andrea Corkhill, Helen Reynolds, Sean Ewings, Susannah Condie, Emma Tilt, Lucy Johnson, Mike Radford, Catherine Simpson, Geoffrey Saunders, Sara Yeats, Pavel Mozgunov, Olana Tansley-Hancock, Karen Martin, Nichola Downs, Izabela Eberhart, Jonathan WB Martin, Cristiana Goncalves, Anna Song, Tom Fletcher, Kelly Byrne, David G Lalloo, Andrew Owen, Michael Jacobs, Lauren Walker, Rebecca Lyon, Christie Woods, Jennifer Gibney, Justin Chiong, Nomathemba Chandiwana, Shevin Jacob, Mohammed Lamorde, Catherine Orrell, Munir Pirmohamed, Saye Khoo, AGILE investigators
Jul 28, 2021
Somatic genetic rescue of a germline ribosome assembly defect.
Shengjiang Tan, Laëtitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Zakaria Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bôle-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cécile Masson, Patrick Nitschké, Mélanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frédéric Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J Bond, Christine Bellanné-Chantelot, Isabelle Callebaut, François Delhommeau, Jean Donadieu, Alan Warren, Patrick Revy
Jul 14, 2021
Germ Cells Cells Cultured Ribosomes Animals Humans Drosophila Dictyostelium Saccharomyces cerevisiae Proteins Ribonucleoprotein U5 Small Nuclear Peptide Elongation Factors Eukaryotic Initiation Factors Biological Phenomena Protein Biosynthesis Protein Binding Sequence Homology Amino Acid Mutation Adolescent Adult Child Child Preschool Infant Ribosome Subunits Large Eukaryotic Young Adult Molecular Dynamics Simulation Shwachman-Diamond Syndrome
Somatic genetic rescue of a germline ribosome assembly defect.
Shengjiang Tan, Laëtitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Z Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bôle-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cécile Masson, Patrick Nitschké, Mélanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frédéric Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J Bond, Christine Bellanné-Chantelot, Isabelle Callebaut, François Delhommeau, Jean Donadieu, Alan J Warren, Patrick Revy
Jun 29, 2022
Adolescent Adult Animals Biological Phenomena Cells Cultured Child Child Preschool Dictyostelium Drosophila Eukaryotic Initiation Factors Germ Cells Humans Infant Molecular Dynamics Simulation Mutation Peptide Elongation Factors Protein Binding Protein Biosynthesis Proteins Ribonucleoprotein U5 Small Nuclear Ribosome Subunits Large Eukaryotic Ribosomes Saccharomyces cerevisiae Sequence Homology Amino Acid Shwachman-Diamond Syndrome Young Adult
Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies.
Tatiana Orme, Dena Hernandez, Owen A Ross, Celia Kun-Rodrigues, Lee Darwent, Claire E Shepherd, Laura Parkkinen, Olaf Ansorge, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, John Q Trojanowski, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda Halliday, David J Stone, Dennis W Dickson, John Hardy, Andrew Singleton, Rita Guerreiro, Jose Bras
Mar 30, 2020
Dementia with Lewy bodies (DLB) is a clinically heterogeneous disorder with a substantial burden on healthcare. Despite this, the genetic basis of the disorder is not well defined and its boundaries with other neurodegenerative...
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