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The evolving view of the hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) reside in specialized microenvironments known as niches. The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation. Recent advances...
Letter to Dr. Simon Flexner, 1929
Library Staff
Jan 01, 0001
Letter to Dr. Simon Flexner, 1929
Published by: Library
Letter to Simon Flexner, 1933
Markus Library
Jan 01, 0001
Letter to Simon Flexner from William Snow, General Director of the American Social Hygiene Association, July 12th, 1933
Published by: Rockefeller University
Simon Flexner, 1911
The Rockefeller University
Jan 01, 0001
Simon Flexner, M.D. Local specific Therapy of Infections
Delivered October 7th, 1911
Published by: J.B. Lippincott Company
Selecting Rotation Constants on SIMON-Type Ciphers
In 2013, a lightweight block cipher SIMON is proposed by NSA. This paper tries to investigate this design criterion in terms of resisting against impossible differential cryptanalysis. On one hand, starting from all the possible...
Published by: IGI Global Scientific Publishing
HSCs revive their niche after transplantation.
Simón Méndez-Ferrer
Dec 11, 2020
Golan K, Singh AK et al.1 describe how mitochondrial transfer from hematopoietic stem cells (HSCs) to bone marrow (BM) mesenchymal stem cells (MSCs) helps to regenerate the stroma and its capacity to sustain hematopoietic...
Molecular interactome between HSCs and their niches.
Simón Méndez-Ferrer
Nov 18, 2019
Because hematopoietic stem cells (HSCs) were found to require a bone marrow (BM) habitat for long-term function, many studies have attempted to dissect key cellular and molecular interactions between HSCs and their BM...
Human and mouse leukocytes
Simón Méndez-Ferrer
Mar 19, 2018
In this issue of Blood, Zhao et al use a humanized mouse model to investigate the mechanisms driving daily oscillations in circulating human and murine leukocytes.1 In the same mice, they find human and murine circulating...
Neuronal regulation of bone marrow stem cell niches.
The bone marrow (BM) is the primary site of postnatal hematopoiesis and hematopoietic stem cell (HSC) maintenance. The BM HSC niche is an essential microenvironment which evolves and responds to the physiological demands of...
Microenvironmental contributions to hematopoietic stem cell aging.
Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-autonomous process, which is the focus of another review in the same issue of Haematologica However, studies on the microenvironment that...
Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow
Mesenchymal stem/stromal cells (MSCs) are present in various body tissues and help in maintaining homeostasis. The stemness of MSCs has been evaluated in vitro. In addition, analyses of cell surface antigens and gene expression...
Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow.
Mesenchymal stem/stromal cells (MSCs) are present in various body tissues and help in maintaining homeostasis. The stemness of MSCs has been evaluated in vitro. In addition, analyses of cell surface antigens and gene expression...
The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions.
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking...
adrenergic Autonomic Nervous System cholinergic Circadian hematopoietic (stem) cells Adrenergic Neurons Animals Autonomic Nervous System Bone Marrow Cell Differentiation Cell Proliferation Cholinergic Neurons Circadian Rhythm Gene Expression Regulation Hematopoietic Stem Cells Humans Periodicity Signal Transduction Stem Cell Niche Suprachiasmatic Nucleus Time Factors
Updates on the hematologic tumor microenvironment and its therapeutic targeting.
Dorian Forte, Daniela S Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer
Sep 23, 2019
In this review article, we present recent updates on the hematologic tumor microenvironment following the 3rd Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the...
Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels.
Sara González-Hernández, Manuel J Gómez, Fátima Sánchez-Cabo, Simón Méndez-Ferrer, Pura Muñoz-Cánoves, Joan Isern
Oct 05, 2020
RATIONALE: The molecular mechanisms underlying the formation of coronary arteries during development and during cardiac neovascularization after injury are poorly understood. However, a detailed description of the relevant...
Animals Coronary Vessels developmental biology Endothelium Gene Expression Regulation Vascular Remodeling Animals Cell Lineage Cells Cultured Chemokine CXCL12 Coronary Vessels Endothelial Cells Gene Expression Regulation Developmental HMGB Proteins Human Umbilical Vein Endothelial Cells Humans Mice Inbred C57BL Mice Knockout Morphogenesis Neovascularization Physiologic Nestin SOXF Transcription Factors Transcription Genetic Transcriptional Activation Transcriptome Vascular Remodeling
Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells
Valentina Salvestrini, Marilena Ciciarello, Valentina Pensato, Giorgia Simonetti, Maria Antonella Laginestra, Samantha Bruno, Martina Pazzaglia, Elena De Marchi, Dorian Forte, Stefania Orecchioni, Giovanni Martinelli, Francesco Bertolini, Simon Méndez-Ferrer, Elena Adinolfi, Francesco Di Virgilio, Michele Cavo, Antonio Curti
Aug 07, 2020
The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central...
Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells
Valentina Salvestrini, Marilena Ciciarello, Valentina Pensato, Giorgia Simonetti, Maria Antonella Laginestra, Samantha Bruno, Martina Pazzaglia, Elena De Marchi, Dorian Forte, Stefania Orecchioni, Giovanni Martinelli, Francesco Bertolini, Simon Méndez-Ferrer, Elena Adinolfi, Francesco Di Virgilio, Michele Cavo, Antonio Curti
Apr 22, 2021
The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central...
Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells.
Valentina Salvestrini, Marilena Ciciarello, Valentina Pensato, Giorgia Simonetti, Maria Antonella Laginestra, Samantha Bruno, Martina Pazzaglia, Elena De Marchi, Dorian Forte, Stefania Orecchioni, Giovanni Martinelli, Francesco Bertolini, Simon Méndez-Ferrer, Elena Adinolfi, Francesco Di Virgilio, Michele Cavo, Antonio Curti
Aug 21, 2020
The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central...
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
Abstract The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving...
Claire Fielding, Andrés García-García, Claudia Korn, Stephen Gadomski, Zijian Fang, Juan L Reguera, José A Pérez-Simón, Berthold Göttgens, Simón Méndez-Ferrer
Jan 28, 2022
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J Farady, Simón Méndez-Ferrer, Radek C Skoda
Sep 13, 2022
Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels...
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages.
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Sep 08, 2021
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2...
Animals Aortic Valve Bone Marrow Transplantation Bone Morphogenetic Protein 2 Calcinosis Cell Lineage Chondrogenesis Endothelial Cells Hematopoiesis Hematopoietic Stem Cells Kaplan-Meier Estimate Mice Inbred C57BL Mice Transgenic Muscle Cells Ossification Heterotopic Osteogenesis Receptor TIE-2 Tomography X-Ray Computed
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