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Semiconductor technology in protein kinase research and drug discovery
Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal...
Generational Cohorts' Reactions
The purpose of this study is to better understand the consumer behaviour, analysing the impact of brand authenticity on two main behavioural outcomes. The research aims also at finding out the behavioural differences of each...
Published by: IGI Global Scientific Publishing
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a...
Protein phosphorylation analysis based on proton release detection
Phosphorylation is the most important post-translational modification of proteins in eukaryotic cells and it is catalysed by enzymes called kinases. The balance between protein phosphorylation and dephosphorylation is critical...
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a...
Published by: Scientific reports
Consistency of Bayesian inference with Gaussian process priors in an elliptic inverse problem
For $\mathcal{O}$ a bounded domain in $\mathbb{R}^d$ and a given smooth
function $g:\mathcal{O}\to\mathbb{R}$, we consider the statistical nonlinear
inverse problem of recovering the conductivity $f>0$ in the divergence...
Crumbs
Joseph Giordano
Jan 01, 0001
A prose story
Magazine Literary Magazine Arts Magazine art poetry prose Creative Nonfiction Photography Creative Writing Creative Writing Nonfiction
Published by: Winthrop University
Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors
Phosphorylation by kinases is an important post-translational modification of proteins. It is a critical control for the regulation of vital cellular activities, and its dysregulation is implicated in several diseases. A common...
Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors
Phosphorylation by kinases is an important post-translational modification of proteins. It is a critical control for the regulation of vital cellular activities, and its dysregulation is implicated in several diseases. A common...
Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Ilaria Canobbio, Caterina Visconte, Barbara Oliviero, Gianni Guidetti, Marta Zara, Giordano Pula, Mauro Torti
Dec 01, 2016
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Ilaria Canobbio, Caterina Visconte, Barbara Oliviero, Gianni Guidetti, Marta Zara, Giordano Pula, Mauro Torti
Dec 01, 2016
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models
Abstract: Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson’s disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described...
Protein phosphorylation analysis based on proton release detection
Phosphorylation is the most important post-translational modification of proteins in eukaryotic cells and it is catalysed by enzymes called kinases. The balance between protein phosphorylation and dephosphorylation is critical...
Plasmonic ruler on field-effect devices for kinase drug discovery applications
Nikhil Bhalla, Nello Formisano, Anna Miodek, Aditya Jain, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela
Sep 15, 2015
Protein kinases are cellular switches that mediate phosphorylation of proteins. Abnormal phosphorylation of proteins is associated with lethal diseases such as cancer. In the pharmaceutical industry, protein kinases have become...
Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease
Ilaria Canobbio, Aisha Alsheikh Abubaker, Caterina Visconte, Mauro Torti, Giordano Pula
Mar 03, 2015
Alzheimer’s disease (AD) is the most common neurodegenerative cause of dementia in the elderly. AD is accompanied by the accumulation of amyloid peptides in the brain parenchyma and in the cerebral vessels. The sporadic form...
Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease
Ilaria Canobbio, Aisha Alsheikh Abubaker, Caterina Visconte, Mauro Torti, Giordano Pula
Mar 03, 2015
Alzheimer’s disease (AD) is the most common neurodegenerative cause of dementia in the elderly. AD is accompanied by the accumulation of amyloid peptides in the brain parenchyma and in the cerebral vessels. The sporadic form...
Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro
Revascularisation is a key step for tissue regeneration and complete organ engineering. We describe the generation of human platelet lysate gel (hPLG), an extracellular matrix preparation from human platelets able to support the...
Semiconductor technology in protein kinase research and drug discovery
Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal...
A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes
Stuart Wallis, Nina Wolska, Hanna Englert, Mareike Posner, Abhishek Upadhyay, Thomas Renne, Ian Eggleston, Stefan Bagby, Giordano Pula
Mar 31, 2022
Aims
P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to...
P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to...
Plasmonic ruler on field-effect devices for kinase drug discovery applications
Nikhil Bhalla, Nello Formisano, Anna Miodek, Aditya Jain, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela
Sep 15, 2015
Protein kinases are cellular switches that mediate phosphorylation of proteins. Abnormal phosphorylation of proteins is associated with lethal diseases such as cancer. In the pharmaceutical industry, protein kinases have become...
MPK6 Kinase Regulates Plasma Membrane H<sup>+</sup>-ATPase Activity in Cold Acclimation.
Ilian Giordano Ponce-Pineda, Laura Carmona-Salazar, Mariana Saucedo-García, Dora Cano-Ramírez, Francisco Morales-Cedillo, Araceli Peña-Moral, Ángel Arturo Guevara-García, Sobeida Sánchez-Nieto, Marina Gavilanes-Ruíz
Aug 02, 2021
Cold and freezing stresses severely affect plant growth, development, and survival rate. Some plant species have evolved a process known as cold acclimation, in which plants exposed to temperatures above 0 °C trigger biochemical...
plasma membrane Cold acclimation MAPK freezing tolerance Mitogen Activated Protein Kinases H+-atpase Mpk3 Mpk6 Cell Membrane Arabidopsis Proton-Translocating ATPases Mitogen-Activated Protein Kinases Arabidopsis Proteins Acclimatization Protein Biosynthesis Transcription Genetic Membrane Fluidity Kinetics Freezing Cold Temperature
Published by: International journal of molecular sciences
Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.
Clive Metcalfe, Anjana Ramasubramoni, Giordano Pula, Matthew T Harper, Stuart J Mundell, Carmen H Coxon
Nov 18, 2016
Benzothiazoles Blood Coagulation Tests Blood Platelets Disulfides Humans Hydroquinones Imidazoles Platelet Activation Platelet Adhesiveness Platelet Aggregation Platelet Aggregation Inhibitors Platelet Function Tests Platelet Membrane Glycoproteins Receptors Collagen Ristocetin Thioredoxins Thrombosis von Willebrand factor
Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro
Revascularisation is a key step for tissue regeneration and complete organ engineering. We describe the generation of human platelet lysate gel (hPLG), an extracellular matrix preparation from human platelets able to support the...
Conservative treatment for cystic duct stenosis in a child.
Marco Gasparetto, Laura Giordano, Mara Cananzi, Valeria Beltrame, Gianni Bisogno, Graziella Guariso
Feb 15, 2019
Introduction. Few cases of common bile duct stenosis have been reported in the literature, and observations of strictures in the cystic duct are even more rare. Surgical cholecystectomy is the treatment needed in most cases of...
Thioredoxin inhibitors attenuate platelet function and thrombus formation
Clive Metcalfe, Anjana Ramasubramoni, Giordano Pula, Matthew T Harper, Stuart J Mundell, Carmen H Coxon
Oct 07, 2016
Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase/thioredoxin system are associated with a number of pathologies, particularly cancer, and a number of...
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