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Voltage-gated sodium (Nav) channels are intrinsic plasma membrane proteins that initiate the action potential in electrically excitable cells. They are a major focus of research in neurobiology, structural biology, membrane...

X-ray crystallography ion channelopathies sodium channel β subunits Action Potentials Amino Acid Sequence Animals evolution Molecular Humans Ion Channel Gating Molecular Sequence Data Voltage-Gated Sodium Channel beta Subunits

The vertebrate sodium (Nav) channel is composed of an ion-conducting α subunit and associated β subunits. Here, we report the crystal structure of the human β3 subunit immunoglobulin (Ig) domain, a functionally important...

Analytical Ultracentrifugation Atomic force microscopy in vivo imaging Photoactivated Localization Microscopy Protein Trimerization Sodium Channels X-ray crystallography Amino Acid Sequence Binding Sites Cloning Molecular Crystallization Crystallography X-Ray Dimerization HEK293 Cells Humans Immunoglobulins Microscopy Atomic Force Molecular Sequence Data NAV1.5 Voltage-Gated Sodium Channel Protein Conformation Ultracentrifugation Voltage-Gated Sodium Channel beta-3 Subunit

regulator genes cell cycle and cell division Gene Expression Carcinogenesis Gene regulation hedgehog signaling Transcription Factors pancreatic cancer

Pancreatic cancer is a lethal disease, with mortality rates negatively associated with the stage at which the disease is detected. Early detection is therefore critical to improving survival outcomes. A recent focus of research...

circulating cell-free tumour DNA pancreatic cancer pancreatic ductal adenocarcinoma

This paper introduces an approach for the VM migration based on optimization algorithm, named CS in cloud. The provider to be selected is carried out with the usage of multiple constraints, like delay, bandwidth, cost, and load....

Semantic Web Computer Science and Information Technology Web Technologies

Biomedical Research Collective Intelligence Crowdsourcing interdisciplinary collaboration research networks translational medicine Biomedical Research Cooperative Behavior Crowdsourcing Humans Intelligence Interdisciplinary Communication Organizational Innovation Translational Research Biomedical

Interaction prediction between the drugs is a preeminent task. Drug - drug interaction (DDI) causes serious effects to human life. The adverse effect can result in death when the interaction is not known. Predicting all DDI is a...

Information Resources Management Social Sciences and Humanities Human Aspects of Technology

Intrinsically disordered proteins (IDPs) and regions (IDRs) form a large part of the eukaryotic proteome. Contrary to the structure-function paradigm, the disordered proteins perform a myriad of functions in vivo. Consequently...

Orphan Drug Rare Diseases 1.1 Normal biological development and functioning 1 Underpinning research Generic Health Relevance

To examine the opportunities on how to be and what to create for the outcomes which will benefit and satisfy the end user (the customer), design thinking applies logic, visualization, and a systematic cerebration. To innovate...

Information Resources Management Social Sciences and Humanities Human Aspects of Technology

T cells Adaptive Immunity innate immunity pancreatic cancer subtypes tumour microenvironment

Emerging Infectious Diseases Rare Diseases Biodefense Infectious Diseases Antimicrobial resistance Prevention Tuberculosis Biotechnology Genetics Vaccine Related Human Genome 2 Aetiology 5 Development of treatments and therapeutic interventions 2.2 Factors relating to the physical environment 5.1 Pharmaceuticals 2.1 Biological and endogenous factors Infection 3 Good Health and Well Being

Distributed networks are networks in which each node can act as a server or client and hence any node can provide service to any other node. In such a scenario, establishing a trust model between the service providing user and...

End-User Computing Computer Science and Information Technology Human-Computer Interaction

Here, we report the isolation of Mycobacterium orygis from dairy cattle in Chennai, India. Spoligotyping assigned the isolate to spoligotype 587 (ST587), which belongs to M. orygis This species was confirmed as M. orygis using...

Genetics Human Genome 3 Good Health and Well Being

BACKGROUND: Primary spontaneous pneumothorax occurs in otherwise healthy young patients. Optimal management is not defined and often results in prolonged hospitalisation. Data on efficacy of ambulatory options are poor. We aimed...

Adult Ambulatory Care Female Hospitalization Humans Length of Stay Male Patient Readmission Pneumothorax Standard of Care United Kingdom

Abstract: TRIP4 is one of the subunits of the transcriptional coregulator ASC-1, a ribonucleoprotein complex that participates in transcriptional coactivation and RNA processing events. Recessive variants in the TRIP4 gene have...

Brief Communication brief-communication

A customer conveys their opinion in natural language about an entity. Applying sentiment analysis to those reviews is a very complex task. The significant terms that influence the polarity of a review are not examined. The terms...

Decision Support Systems Computer Science and Information Technology Decision Support Systems

Brief Communication brief-communication