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English Professor Explores Jung, Africa in New Text
Winthrop University
Jan 01, 0001
Fike joined the Winthrop community in 2000 and teaches courses on Shakespeare and Renaissance literature. Past publications include three critical books: "Spenser's Underworld in the 1590 'Faerie Queen'"; "A Jungian Study of...
Published by: Winthrop University
Automatic materials characterization from infrared spectra using convolutional neural networks.
Infrared spectroscopy is a ubiquitous technique used to characterize unknown materials in the form of solids, liquids, or gases by identifying the constituent functional groups of molecules through the analysis of obtained...
Published by: Chemical science
Current-controlled nanomagnetic writing for reconfigurable magnonic crystals
Abstract: Strongly-interacting nanomagnetic arrays are crucial across an ever-growing suite of technologies. Spanning neuromorphic computing, control over superconducting vortices and reconfigurable magnonics, the utility and...
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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Knight's Moves
Emily Gowers
Jul 09, 2019
While the relationship between fathers and sons, real or metaphorical, is still a dominant paradigm among classicists, this paper considers the rival contribution of Roman sons-in-law to the processes of collaboration and...
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Leucine regulates autophagy via acetylation of the mTORC1 component raptor.
Macroautophagy ("autophagy") is the main lysosomal catabolic process that becomes activated under nutrient-depleted conditions, like amino acid (AA) starvation. The mechanistic target of rapamycin complex 1 (mTORC1) is a...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Published by:
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis

MicroRNAs are differentially expressed in breast cancer cells and have been implicated in cancer formation, tumour invasion and metastasis. We investigated the miRNA expression profiles in the developing mammary gland....

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A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis

MicroRNAs are differentially expressed in breast cancer cells and have been implicated in cancer formation, tumour invasion and metastasis. We investigated the miRNA expression profiles in the developing mammary gland....

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A.
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this...
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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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