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Results: 43
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
Sarvenaz Metghalchi, Marie Vandestienne, Yacine Haddad, Bruno Esposito, Julien Dairou, Alain Tedgui, Ziad Mallat, Stephane Potteaux, Soraya Taleb
Jun 21, 2018
AIMS: Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix degradation. Despite considerable progress in...
Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms.
Marc Clément, Joel Chappell, Juliette Raffort, Fabien Lareyre, Marie Vandestienne, Annabel L Taylor, Alison Finigan, James Harrison, Martin R Bennett, Patrick Bruneval, Soraya Taleb, Helle F Jørgensen, Ziad Mallat
Mar 29, 2019
Objective- Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the...
Angiotensin II Autophagy clones Endoplasmic Reticulum Inflammation Mice Smooth muscle cells Adult Aged aortic dissection Angiotensin II Animals Aorta Aortic Aneurysm Autophagy Autophagy-Related Protein 5 Cell Lineage Cell Plasticity Cells Cultured Disease Models Animal Endoribonucleases Female Humans Male Mice 129 Strain Mice Inbred C57BL Mice Knockout ApoE Middle Aged Muscle Smooth Vascular Myocytes Smooth Muscle Phenotype Protein Serine-Threonine Kinases Signal Transduction
Deletion of IRF8 (Interferon Regulatory Factor 8)-Dependent Dendritic Cells Abrogates Proatherogenic Adaptive Immunity.
Marc Clément, Yacine Haddad, Juliette Raffort, Fabien Lareyre, Stephen A Newland, Leanne Master, James Harrison, Maria Ozsvar-Kozma, Patrick Bruneval, Christoph J Binder, Soraya Taleb, Ziad Mallat
Jun 20, 2018
RATIONALE: Despite an established role for adaptive immune responses in atherosclerosis, the contribution of dendritic cells (DCs) and their various subsets is still poorly understood. OBJECTIVE: Here, we address the role of...
The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice.
Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi, Lynda Zeboudj, Andreas Giraud, Xavier Loyer, Marie Vandestienne, Julien Wain-Hobson, Bruno Esposito, Stephane Potteaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat, Soraya Taleb
Jun 21, 2018
RATIONALE: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between...
Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis.
Jeremie Joffre, Stephane Potteaux, Lynda Zeboudj, Xavier Loyer, Amir Boufenzer, Ludivine Laurans, Bruno Esposito, Marie Vandestienne, Saskia CA de Jager, Carole Hénique, Ivana Zlatanova, Soraya Taleb, Patrick Bruneval, Alain Tedgui, Ziad Mallat, Sebastien Gibot, Hafid Ait-Oufella
Jun 21, 2018
BACKGROUND: Innate immune responses activated through myeloid cells contribute to the initiation, progression, and complications of atherosclerosis in experimental models. However, the critical upstream pathways that link innate...
apolipoprotein foam cells Inflammation macrophage Toll-like receptor Animals Apoptosis Carotid Arteries Carotid Artery Diseases Cells Cultured Disease Models Animal Enzyme-Linked Immunosorbent Assay Genetic Therapy Humans Immunity Innate Lauric Acids MACROPHAGES Male Membrane Glycoproteins Mice Mice Inbred C57BL Mice Transgenic Oligopeptides Plaque Atherosclerotic Receptors Immunologic Rhodamines Triggering Receptor Expressed on Myeloid Cells-1
TGFβ (Transforming Growth Factor-β) Blockade Induces a Human-Like Disease in a Nondissecting Mouse Model of Abdominal Aortic Aneurysm.
Fabien Lareyre, Marc Clément, Juliette Raffort, Stefanie Pohlod, Meghana Patel, Bruno Esposito, Leanne Master, Alison Finigan, Marie Vandestienne, Nikolaos Stergiopulos, Soraya Taleb, Bram Trachet, Ziad Mallat
Mar 19, 2019
OBJECTIVE: Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGFβ (transforming growth factor-β) activity-a guardian of...
Aneurysm Animals Humans Immune System Models Animals Antibodies Monoclonal Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Apolipoproteins E Chemotaxis Leukocyte Dilatation Pathologic Disease Models Animal Disease Progression Extracellular Matrix Interleukin-1beta Kinetics Male Mice Inbred C57BL Mice Knockout Pancreatic Elastase Synchrotrons Thrombosis Transforming Growth Factor beta Ultrasonography Vascular Remodeling Wound Healing
Type-2 innate lymphoid cells control the development of atherosclerosis in mice.
Stephen A Newland, Sarajo Mohanta, Marc Clément, Soraya Taleb, Jennifer A Walker, Meritxell Nus, Andrew P Sage, Changjun Yin, Desheng Hu, Lauren L Kitt, Alison J Finigan, Hans-Reimer Rodewald, Christoph J Binder, Andrew NJ McKenzie, Andreas J Habenicht, Ziad Mallat
Jun 19, 2018
Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose tissue. Despite their role in limiting obesity, how ILC2s respond to high...
Psychotherapeutic interventions for childhood posttraumatic stress disorder
Purpose of the review. We review treatment outcome studies and systematic reviews for childhood and adolescent posttraumatic stress disorder (PTSD) between January 2020 and August 2022, including studies involving younger...
Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine.
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, José Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sébastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sébastien Silvestre, Soraya Taleb
Dec 07, 2020
BACKGROUND: Ischemic cardiovascular diseases, particularly acute myocardial infarction (MI), is one of the leading causes of mortality worldwide. Indoleamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of...
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.
Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud, Ludivine Laurans, Bruno Esposito, Florence Pinet, Patrick Bruneval, Juliette Raffort, Fabien Lareyre, Jose Vilar, Amir Boufenzer, Lea Guyonnet, Coralie Guerin, Eric Clauser, Jean-Sébastien Silvestre, Sylvie Lang, Laurie Soulat-Dufour, Alain Tedgui, Ziad Mallat, Soraya Taleb, Alexandre Boissonnas, Marc Derive, Giulia Chinetti, Hafid Ait-Oufella
Dec 07, 2020
The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the...
Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production.
Sarvenaz Metghalchi, Padmapriya Ponnuswamy, Tabassome Simon, Yacine Haddad, Ludivine Laurans, Marc Clément, Marion Dalloz, Mélissa Romain, Bruno Esposito, Vincent Koropoulis, Bruno Lamas, Jean-Louis Paul, Yves Cottin, Salma Kotti, Patrick Bruneval, Jacques Callebert, Hester den Ruijter, Jean-Marie Launay, Nicolas Danchin, Harry Sokol, Alain Tedgui, Soraya Taleb, Ziad Mallat
Mar 20, 2019
Indoleamine 2,3-dioxygenase 1 (Ido1) is a rate-limiting enzyme that catalizes the degradation of tryptophan along the kynurenine pathway. Here, we show that Ido1 activity sustains an immunostimulatory potential through...
Lesions Detection of Multiple Sclerosis in 3D Brian MR Images by Using Artificial Immune Systems and Support Vector Machines
This paper presents a segmentation method to detect multiple sclerosis (MS) lesions in brain MRI based on the artificial immune systems (AIS) and a support vector machines (SVM). In the first step, AIS is used to segment the...
Medicine and Healthcare Medical Diagnosis and Practice Medical Imaging Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
Psychotherapeutic interventions for childhood posttraumatic stress disorder
Purpose of the review. We review treatment outcome studies and systematic reviews for childhood and adolescent posttraumatic stress disorder (PTSD) between January 2020 and August 2022, including studies involving younger...
Correlation Constraints for Regression Models
Matthias S. Treder, Jonathan P. Shock, Dan J. Stein, Stéfan du Plessis, Soraya Seedat, Kamen A. Tsvetanov
Mar 04, 2021
In neuroimaging, the difference between chronological age and predicted brain age, also known as brain age delta, has been proposed as a pathology marker linked to a range of phenotypes. Brain age delta is estimated using...
Lesions Detection of Multiple Sclerosis in 3D Brian MR Images by Using Artificial Immune Systems and Support Vector Machines
This paper presents a segmentation method to detect multiple sclerosis (MS) lesions in brain MRI based on the artificial immune systems (AIS) and a support vector machines (SVM). In the first step, AIS is used to segment the...
Published by: IGI Global Scientific Publishing
Sex differences in the severity and natural recovery of child PTSD symptoms
Lucy V Hiscox, S. Bray, Abigail Fraser, Richard Meiser-Stedman, Soraya Seedat, Sarah Halligan
Apr 10, 2023
Background: Higher levels of PTSD symptoms are present among trauma-exposed females v. males in adulthood; however, much less is known about the emergence of this sex difference during...
The emergence of sex differences in PTSD symptoms across development
Katharina Haag, Abigail Fraser, Rachel Hiller, Soraya Seedat, Annie Zimmerman, Sarah Halligan
Jul 31, 2020
Background
Cross-sectional evidence suggests females in late adolescence exhibit higher rates of post-traumatic stress symptoms (PTSS) than males and younger age groups. However, longitudinal evidence is limited, and...
Cross-sectional evidence suggests females in late adolescence exhibit higher rates of post-traumatic stress symptoms (PTSS) than males and younger age groups. However, longitudinal evidence is limited, and...
The emergence of sex differences in PTSD symptoms across development
Katharina Haag, Abigail Fraser, Rachel Hiller, Soraya Seedat, Annie Zimmerman, Sarah Halligan
Jul 31, 2020
Background
Cross-sectional evidence suggests females in late adolescence exhibit higher rates of post-traumatic stress symptoms (PTSS) than males and younger age groups. However, longitudinal evidence is limited, and...
Cross-sectional evidence suggests females in late adolescence exhibit higher rates of post-traumatic stress symptoms (PTSS) than males and younger age groups. However, longitudinal evidence is limited, and...
Sex differences in the severity and natural recovery of child PTSD symptoms
Lucy V Hiscox, S. Bray, Abigail Fraser, Richard Meiser-Stedman, Soraya Seedat, Sarah Halligan
Apr 10, 2023
Background: Higher levels of PTSD symptoms are present among trauma-exposed females v. males in adulthood; however, much less is known about the emergence of this sex difference during...
Semantic Segmentation of Hippocampal Subregions With U-Net Architecture
The Automatic semantic segmentation of the hippocampus is an important area of research in which several convolutional neural networks (CNN) models have been used to detect the hippocampus from whole cerebral MRI. In this paper...
Published by: IGI Global Scientific Publishing
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Ludivine Laurans, Nicolas Venteclef, Yacine Haddad, Mouna Chajadine, Fawaz Alzaid, Sarvenaz Metghalchi, Bruno Sovran, Raphael GP Denis, Julien Dairou, Marina Cardellini, Jose-Maria Moreno-Navarrete, Marjolene Straub, Sarah Jegou, Claire McQuitty, Thomas Viel, Bruno Esposito, Bertrand Tavitian, Jacques Callebert, Serge H Luquet, Massimo Federici, José Manuel Fernandez-Real, Remy Burcelin, Jean-Marie Launay, Alain Tedgui, Ziad Mallat, Harry Sokol, Soraya Taleb
Sep 08, 2018
The association between altered gut microbiota, intestinal permeability, inflammation and cardiometabolic diseases is becoming increasingly clear but remains poorly understood1,2. Indoleamine 2,3-dioxygenase is an enzyme induced...
ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis.
Effectiveness of digital and remote provision of the Healthier You
Emma Barron, Dominque Bradley, Soraya Safazadeh, Ben McGough, Chirag Bakhai, Bob Young, Kamlesh Khunti, Elizabeth Murray, Nick Wareham, Susan Jebb, Jonathan Valabhji
Jan 22, 2023
AIMS: To assess weight change in the Healthier You: NHS Diabetes Prevention Programme (NHS DPP) delivered via video conferencing (remote) sessions or delivered via specific digital interventions through apps or websites, during...
Hyperspectral confocal imaging for high-throughput readout and analysis of bio-integrated microlasers
Vera M Titze, Soraya Caixeiro, Vinh San Dinh, Matthias König, Matthias Rübsam, Nachiket Pathak, Anna-Lena Schumacher, Maximilian Germer, Christian Kukat, Carien M Niessen, Marcel Schubert, Malte C Gather
Jan 18, 2024
Integrating micro- and nanolasers into live cells, tissue cultures and small animals is an emerging and rapidly evolving technique that offers noninvasive interrogation and labeling with unprecedented information density. The...
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