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Results: 15648
Maxwell-Stefan diffusion coefficient estimation for ternary systems
C D'Agostino
Aug 02, 2017
The Maxwell–Stefan model is a popular diffusion model originally developed to model diffusion of gases, which can be considered thermodynamically ideal mixtures, although its application has been extended to model diffusion in...
On melting and freezing for the 2D radial Stefan problem
We consider the two dimensional free boundary Stefan problem describing the evolution of a spherically symmetric ice ball $\{r\leq \l(t)\}$. We revisit the pioneering analysis of \cite{HeVe} and prove the existence in the radial...
HiCUP
Steven Wingett, Philip Ewels, Mayra Furlan-Magaril, Takashi Nagano, Stefan Schoenfelder, Peter Fraser, Simon Andrews
Jul 15, 2019
HiCUP is a pipeline for processing sequence data generated by Hi-C and Capture Hi-C (CHi-C) experiments, which are techniques used to investigate three-dimensional genomic organisation. The pipeline maps data to a specified...
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 16, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 19, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Comparison of Hi-C results using in-solution versus in-nucleus ligation.
Takashi Nagano, Csilla Várnai, Stefan Schoenfelder, Biola-Maria Javierre, Steven W Wingett, Peter Fraser
Jul 15, 2019
BACKGROUND: Chromosome conformation capture and various derivative methods such as 4C, 5C and Hi-C have emerged as standard tools to analyze the three-dimensional organization of the genome in the nucleus. These methods employ...
CHiCAGO
Jonathan Cairns, Paula Freire-Pritchett, Steven W Wingett, Csilla Várnai, Andrew Dimond, Vincent Plagnol, Daniel Zerbino, Stefan Schoenfelder, Biola-Maria Javierre, Cameron Osborne, Peter Fraser, Mikhail Spivakov
Jul 15, 2019
Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving targeted regions of interest, such as gene promoters, globally and at high resolution. Signal detection in CHi-C data involves a number of...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, Michael WJ Hall, Agnieszka Wabik, Stefan C Dentro, Joanna C Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A Hall, Philip H Jones
Apr 28, 2020
ADAM10 Protein Amyloid Precursor Protein Secretases Animals Cell Lineage Diethylnitrosamine Epithelium esophagus Female High-Throughput Nucleotide Sequencing Male Membrane Proteins Mice Inbred C57BL Mice Transgenic Mutation Receptor Notch1 Receptor Notch2 Reproducibility of Results Tumor Suppressor Protein p53
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.
Borbala Mifsud, Inigo Martincorena, Elodie Darbo, Robert Sugar, Stefan Schoenfelder, Peter Fraser, Nicholas M Luscombe
Jul 15, 2019
Hi-C is one of the main methods for investigating spatial co-localisation of DNA in the nucleus. However, the raw sequencing data obtained from Hi-C experiments suffer from large biases and spurious contacts, making it difficult...
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
Roland Jäger, Gabriele Migliorini, Marc Henrion, Radhika Kandaswamy, Helen E Speedy, Andreas Heindl, Nicola Whiffin, Maria J Carnicer, Laura Broome, Nicola Dryden, Takashi Nagano, Stefan Schoenfelder, Martin Enge, Yinyin Yuan, Jussi Taipale, Peter Fraser, Olivia Fletcher, Richard S Houlston
Jul 15, 2019
Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide...
The ALPINE–ALMA [C ii] Survey
Abstract
We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field...
Lu Shen, Brian C Lemaux, Lori M Lubin, Guilin Liu, Matthieu Béthermin, Médéric Boquien, Olga Cucciati, Olivier Le Fèvre, Margherita Talia, Daniela Vergani, Gianni Zamorani, Andreas L Faisst, Michele Ginolfi, Carlotta Gruppioni, Gareth C Jones, Sandro Bardelli, Nimish Hathi, Anton M Koekemoer, Michael Romano, Daniel Schaerer, Elena Zucca, Wenjuan Fang, Ben Forrest, Roy Gal, Denise Hung, Ekta A Shah, Priti Staab, Brittany Vanderhoof, Eduardo Ibar
Aug 24, 2022
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Polymorphism in killer cell immunoglobulin-like receptors and human leukocyte antigen-c and predisposition to preeclampsia in Ethiopian pregnant women population.
Tsehayneh Kelemu, Lena Erlandsson, Daniel Seifu, Eva Hansson, Markos Abebe, Sisay Teklu, Selfu Girma, James A Traherne, Ashley Moffett, Stefan R Hansson
Jun 26, 2020
INTRODUCTION: Preeclampsia (PE) is a human specific pregnancy-related syndrome of unknown etiology that affects 2-8 % of pregnancies. Polymorphism in maternal Killer Cell Immunoglobulin-like Receptors (KIRs) and the ligand fetal...
HLA KIR natural killer cell Preeclampsia Trophoblast cell Adolescent Adult Case-Control Studies Ethiopia Female Fetus Gene Frequency Genetic Predisposition to Disease HLA-C Antigens Humans Immune Tolerance Killer Cells Natural Polymorphism Single Nucleotide pre-eclampsia Pregnancy Protective factors Receptors KIR Young Adult
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure.
Takashi Nagano, Yaniv Lubling, Tim J Stevens, Stefan Schoenfelder, Eitan Yaffe, Wendy Dean, Ernest D Laue, Amos Tanay, Peter Fraser
Jul 15, 2019
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture (3C) assess contacts for...
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours
Louise Harewood, Kamal Kishore, Matthew D Eldridge, Steven Wingett, Danita Pearson, Stefan Schoenfelder, V. P Collins, Peter Fraser
Jun 28, 2017
Abstract
Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and...
Search for the doubly heavy baryons Ω<inf>bc</inf><sup>0</sup>and Ξ<inf>bc</inf><sup>0</sup>decaying to Λ<inf>c</inf><sup>+</sup>π- And Ξ<inf>c</inf><sup>+</sup>π- And c
C Nguyen-Mau, R Aaij, C Abellán Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, G Alkhazov, P Alvarez Cartelle, S Amato, Y Amhis, L An, L Anderlini, A Andreianov, M Andreotti, F Archilli, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, M Bachmayer, JJ Back, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista Leite, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, JM Basels, G Bassi, B Batsukh, A Battig, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, V Belavin, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, I Bezshyiko, S Bhasin, J Bhom, L Bian, MS Bieker, S Bifani, P Billoir, M Birch, FCR Bishop, A Bitadze, A Bizzeti, M Bj rn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, JA Boelhauve, O Boente Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, SA Bouchiba, TJV Bowcock, A Boyer, C Bozzi, MJ Bradley
Aug 31, 2021
The first search for the doubly heavy $\it{\Omega}_{bc}^{\rm0}$ baryon and a
search for $\it{\Xi}_{bc}^{\rm0}$ baryon are performed using $pp$ collision
data collected via the LHCb experiment from 2016 to 2018 at a...
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
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