Search
Results: 1238
Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp.
The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp). Combining...
Aminoacyltransferases Bacterial Proteins Biophysical Phenomena Chemistry Techniques Analytical Cysteine Endopeptidases Cytochromes c Electrophoresis Polyacrylamide Gel Heme Kinetics Maltose Maltose-Binding Proteins Point Mutation Protein Binding Protein Denaturation Protein Folding Protein Stability Protein Structure Tertiary Protein Unfolding Proteins Proteolysis Reproducibility of Results Temperature Thermolysin
Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.
Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown. Here, we characterise the Mutation Cluster Region in APC...
The growth and superconducting properties of RE–Ba–Cu–O single grains with combined RE elements (RE = Gd and Y)
Yunhua Shi, Giovanni Bergamo-Andreis, Anthony R Dennis, John H Durrell, David A Cardwell
Feb 04, 2020
Abstract: The superconducting properties, melting temperatures and crystal growth rates of single grain, RE–Ba–Cu–O [(RE)BCO] bulk superconductors (where RE = a rare earth element or yttrium) decrease with the RE-element...
Maxwell-Stefan diffusion coefficient estimation for ternary systems
C D'Agostino
Aug 02, 2017
The Maxwell–Stefan model is a popular diffusion model originally developed to model diffusion of gases, which can be considered thermodynamically ideal mixtures, although its application has been extended to model diffusion in...
On melting and freezing for the 2D radial Stefan problem
We consider the two dimensional free boundary Stefan problem describing the evolution of a spherically symmetric ice ball $\{r\leq \l(t)\}$. We revisit the pioneering analysis of \cite{HeVe} and prove the existence in the radial...
Inter-Network Brain Functional Connectivity in Adolescents Assigned Female at Birth Who Experience Gender Dysphoria.
Malvina N Skorska, Nancy J Lobaugh, Michael V Lombardo, Nina van Bruggen, Sofia Chavez, Lindsey T Thurston, Madison Aitken, Kenneth J Zucker, M Mallar Chakravarty, Meng-Chuan Lai, Doug P VanderLaan
Aug 05, 2022
Gender dysphoria (GD) is characterized by distress due to an incongruence between experienced gender and sex assigned at birth. Brain functional connectivity in adolescents who experience GD may be associated with experienced...
Distribution of the superconducting critical current density within a Gd–Ba–Cu–O single grain
Abstract: The magnitude of the maximum trapped magnetic field in a bulk, single-grain superconductor is a key performance figure of merit. This is determined, generally, by the magnitude of the critical current density, Jc, and...
Abnormalities of striatal morphology in gambling disorder and at-risk gambling.
OBJECTIVE: The clinical phenotype of gambling disorder (GD) is suggestive of changes in brain regions involved in reward and impulse suppression, notably the striatum. Studies have yet to characterize striatal morphology (shape)...
Distribution of the superconducting critical current density within a Gd–Ba–Cu–O single grain
Abstract: The magnitude of the maximum trapped magnetic field in a bulk, single-grain superconductor is a key performance figure of merit. This is determined, generally, by the magnitude of the critical current density, Jc, and...
Cold pressor pain and gambling disorder
OBJECTIVE: Gambling disorder (GD) is a common, disabling condition that often is exacerbated by stressful life events. Under stress, the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are activated. The...
Alemtuzumab-Induced Thyroid Dysfunction Exhibits Distinctive Clinical and Immunological Features.
Nadia Pariani, Mark Willis, Ilaria Muller, Sarah Healy, Taha Nasser, Anne McGowan, Greta Lyons, Joanne Jones, Krishna Chatterjee, Colin Dayan, Neil Robertson, Alasdair Coles, Carla Moran
Oct 10, 2018
CONTEXT: Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves disease (GD), with a reportedly indolent course. OBJECTIVE: To determine the type, frequency, and course of thyroid...
A Multi-Modal MRI Analysis of Cortical Structure in Relation to Gender Dysphoria, Sexual Orientation, and Age in Adolescents.
Malvina N Skorska, Sofia Chavez, Gabriel A Devenyi, Raihaan Patel, Lindsey T Thurston, Meng-Chuan Lai, Kenneth J Zucker, M Mallar Chakravarty, Nancy J Lobaugh, Doug P VanderLaan
Jan 19, 2021
Gender dysphoria (GD) is characterized by distress due to an incongruence between experienced gender and sex assigned at birth. Sex-differentiated brain regions are hypothesized to reflect the experienced gender in GD and may...
The (in)dependence of alternative splicing and gene duplication.
Alternative splicing (AS) and gene duplication (GD) both are processes that diversify the protein repertoire. Recent examples have shown that sequence changes introduced by AS may be comparable to those introduced by GD. In...
Neuropsychological Features of Gaming Disorder and Psychiatric Comorbidities
This article highlights current research on gaming disorder (GD), focusing primarily on neuropsychological features. Advances in digital technology have made gaming more accessible, realistic, and competitive than ever before...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity
Tatiana Raskovalova, Patrick B Deegan, Ruby Yang, Elena Pavlova, Jérome Stirnemann, José Labarère, Ari Zimran, Pramod K Mistry, Marc Berger
May 05, 2017
BACKGROUND: Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course....
Anemia Biomarkers Chemokines CC Gaucher Disease Hepatomegaly Hexosaminidases Humans Splenomegaly Thrombocytopenia Anemia Biomarkers Chemokines CC Gaucher Disease Hepatomegaly Hexosaminidases Humans Meta-Analysis as Topic Research Design Severity of Illness Index Splenomegaly Systematic Reviews as Topic Thrombocytopenia
Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1.
A Dardis, H Michelakakis, P Rozenfeld, K Fumic, J Wagner, E Pavan, M Fuller, S Revel-Vilk, D Hughes, T Cox, J Aerts, International Working Group of Gaucher Disease (IWGGD)
Jan 22, 2023
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder due to the deficient activity of the acid beta-glucosidase (GCase) enzyme, resulting in the progressive lysosomal accumulation of glucosylceramide...
The Marshall Plan: A Critique of the European Recovery Program
Louis D. Stefan
Jan 01, 0001
This 48 page thesis examines the Marshall Plan for European recovery following World War II.
World War II Marshall Plan world trade Tariffs Aldrich Plan Krug Report Business Economic History Economics European History International Economics Social and Behavioral Sciences
Published by: Ursinus College
Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1.
A Dardis, H Michelakakis, P Rozenfeld, K Fumic, J Wagner, E Pavan, M Fuller, S Revel-Vilk, D Hughes, T Cox, J Aerts, International Working Group of Gaucher Disease (IWGGD)
Dec 21, 2022
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder due to the deficient activity of the acid beta-glucosidase (GCase) enzyme, resulting in the progressive lysosomal accumulation of glucosylceramide...
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
Ganqiang Liu, Brendon Boot, Joseph J Locascio, Iris E Jansen, Sophie Winder-Rhodes, Shirley Eberly, Alexis Elbaz, Alexis Brice, Bernard Ravina, Jacobus J van Hilten, Florence Cormier-Dequaire, Jean-Christophe Corvol, Roger A Barker, Peter Heutink, Johan Marinus, Caroline H Williams-Gray, Clemens R Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium
May 16, 2018
OBJECTIVE: We hypothesized that specific mutations in the β-glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease (PD)...
When Emotions Rule Knowledge
Although emotions play an important role in human behavior and knowledge studies, knowledge management (KM) research considers them from specific angles and, to date, has lacked a comprehensive understanding of the emotions...
Published by: IGI Global Scientific Publishing
Expert appraisal of criteria for assessing gaming disorder
Jesús Castro-Calvo, Daniel L King, Dan J Stein, Matthias Brand, Lior Carmi, Samuel R Chamberlain, Zsolt Demetrovics, Naomi A Fineberg, Hans-Jürgen Rumpf, Murat Yücel, Sophia Achab, Atul Ambekar, Norharlina Bahar, Alexander Blaszczynski, Henrietta Bowden-Jones, Xavier Carbonell, Elda Mei Lo Chan, Chih-Hung Ko, Philippe de Timary, Magali Dufour, Marie Grall-Bronnec, Hae Kook Lee, Susumu Higuchi, Susana Jimenez-Murcia, Orsolya Király, Daria J Kuss, Jiang Long, Astrid Müller, Stefano Pallanti, Marc N Potenza, Afarin Rahimi-Movaghar, John B Saunders, Adriano Schimmenti, Seung-Yup Lee, Kristiana Siste, Daniel T Spritzer, Vladan Starcevic, Aviv M Weinstein, Klaus Wölfling, Joël Billieux
Aug 02, 2021
BACKGROUND AND AIMS: Following the recognition of 'internet gaming disorder' (IGD) as a condition requiring further study by the DSM-5, 'gaming disorder' (GD) was officially included as a diagnostic entity by the World Health...
The Grizzly, September 23, 1996
Jared Rakes, Erin Gambeski, Taneille Smith, Todd Brenneman, Mark Turney, Sean Campbell, Jen Mintzer, Cristin Veit, Kerrie McKinney, Teresa Green, Joel Schofer, Brian Hamrick, Tony Palladino, Andrew Ruhf, Hera Walker
Jan 01, 0001
Internet Censorship Issue Addressed by Stefan Presser Opinions: Life in a Determinist World; Are Guns Necessary? Study Abroad to Have Fun and Learn Get Moving: A Guide to the Benefits of Exercise Anthonisen Exhibit Captures...
Ursinus College Collegeville Pennsylvania newspaper Soccer field hockey Volleyball Football Megan Larkin Berman Art Museum study abroad NRA Ryan Auch ACLU Censorship cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
A Dynamic Multi-Swarm Particle Swarm Optimization With Global Detection Mechanism
To overcome the shortcomings of the standard particle swarm optimization algorithm (PSO), such as premature convergence and low precision, a dynamic multi-swarm PSO with global detection mechanism (DMS-PSO-GD) is proposed. In...
Published by: IGI Global Scientific Publishing
2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy.
Ilaria Muller, Carla Moran, Beatriz Lecumberri, Brigitte Decallonne, Neil Robertson, Joanne Jones, Colin M Dayan
May 03, 2019
Thyroid dysfunction (TD) frequently occurs as an autoimmune complication of immune reconstitution therapy (IRT), especially in individuals with multiple sclerosis treated with alemtuzumab, a pan-lymphocyte depleting drug with...
|
|< |
< |
1 |