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The TRAPP complexes
The Transport Protein Particle (TRAPP) complexes are highly conserved multisubunit complexes that act as nucleotide exchange factors (GEFs) for Rab GTPases. They act in both protein secretion and autophagy and have also been...
A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1
Abstract: The presence of large numbers of local interneurons in the olfactory bulb has demonstrated an extensive local signaling process, yet the identification and purpose of olfactory microcircuits is poorly explored. Because...
Maxwell-Stefan diffusion coefficient estimation for ternary systems
C D'Agostino
Aug 02, 2017
The Maxwell–Stefan model is a popular diffusion model originally developed to model diffusion of gases, which can be considered thermodynamically ideal mixtures, although its application has been extended to model diffusion in...
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain.
Simon C Cork, James E Richards, Marie K Holt, Fiona M Gribble, Frank Reimann, Stefan Trapp
Nov 10, 2017
OBJECTIVE: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable. This study...
AP area postrema BNST bed nucleus stria terminalis Channelrhodopsin DMH dorsomedial nucleus of the hypothalamus DMV dorsal motor nucleus of the vagus Electrophysiology Ex-4 Exendin-4 GFAP glial fibrillary acidic protein GFP green fluorescent protein GLP-1 GLP-1 Glucagon-like peptide-1 GLP-1R Glucagon-like peptide-1 receptor Glucagon-Like Peptide-1 Receptor NAc nucleus accumbens NTS nucleus of the solitary tract PARV parvalbumin PPG PPG preproglucagon PVN paraventricular nucleus of the hypothalamus Preproglucagon TH tyrosine hydroxylase VTA ventral tegmental area YFP yellow fluorescent protein
A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1.
The presence of large numbers of local interneurons in the olfactory bulb has demonstrated an extensive local signaling process, yet the identification and purpose of olfactory microcircuits is poorly explored. Because the...
On melting and freezing for the 2D radial Stefan problem
We consider the two dimensional free boundary Stefan problem describing the evolution of a spherically symmetric ice ball $\{r\leq \l(t)\}$. We revisit the pioneering analysis of \cite{HeVe} and prove the existence in the radial...
Diffusion and sorption of trace organic micropollutants in biofilm with varying thickness
Elena Torresi, Fabio Polesel, Kai Bester, Magnus Christensson, Barth F. Smets, Stefan Trapp, Henrik R. Andersen, Benedek Gy. Plosz
Oct 15, 2017
Solid-liquid partitioning is one of the main fate processes determining the removal of micropollutants in wastewater. Little is known on the sorption of micropollutants in biofilms, where molecular diffusion may significantly...
Diffusion and sorption of trace organic micropollutants in biofilm with varying thickness
Elena Torresi, Fabio Polesel, Kai Bester, Magnus Christensson, Barth F. Smets, Stefan Trapp, Henrik R. Andersen, Benedek Gy. Plosz
Oct 15, 2017
Solid-liquid partitioning is one of the main fate processes determining the removal of micropollutants in wastewater. Little is known on the sorption of micropollutants in biofilms, where molecular diffusion may significantly...
PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice.
Marie K Holt, Daniel R Cook, Daniel I Brierley, James E Richards, Frank Reimann, Alexander V Gourine, Nephtali Marina, Stefan Trapp
Jun 01, 2020
OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used as anti-diabetic drugs and are approved for obesity treatment. However, GLP-1RAs also affect heart rate (HR) and arterial blood pressure (ABP) in rodents...
Biotelemetry cardiovascular function Chemogenetics GLP-1 PPG neurons Sympathetic outflow Animals Disease Models Animal Electrocardiography Exenatide Glucagon-Like Peptide-1 Receptor Heart Rate Mice Mice Transgenic Neurons Proglucagon Solitary Nucleus Spinal Cord sympathetic nervous system Tachycardia
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jun 04, 2021
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
cerebral blood flow Middle cerebral artery occlusion Neuroprotection Ischaemic stroke Brain capillaries Brain arterioles Glucagon-like peptide-1 Remote ischaemic preconditioning
Published by: Basic research in cardiology
The Marshall Plan: A Critique of the European Recovery Program
Louis D. Stefan
Jan 01, 0001
This 48 page thesis examines the Marshall Plan for European recovery following World War II.
World War II Marshall Plan world trade Tariffs Aldrich Plan Krug Report Business Economic History Economics European History International Economics Social and Behavioral Sciences
Published by: Ursinus College
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N. Christie, Shefeeq M. Theparambil, Sean M. Davidson, Frank Reimann, Stefan Trapp, Derek M. Yellon, Alexander V. Gourine
May 04, 2021
Abstract: Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct...
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jul 21, 2021
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.
The TRAPP complexes are nucleotide exchange factors that play essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that...
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.
Stefan Wagner, Daniel I Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian YH Lam, Georgina KC Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M Gribble, Pablo B Martinez de Morentin, Giles SH Yeo, Stefan Trapp, Lora K Heisler
Feb 02, 2023
OBJECTIVE: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like...
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jan 28, 2022
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
Brain capillaries Brain arterioles cerebral blood flow Glucagon-like peptide-1 Ischaemic stroke Middle cerebral artery occlusion Neuroprotection Remote ischaemic preconditioning Animals Arterioles Cerebrovascular Circulation Disease Models Animal Glucagon-Like Peptide-1 Receptor Hindlimb Incretins Infarction Middle Cerebral artery Ischemic preconditioning ischemic stroke Male Neuroprotective Agents Peptide Fragments Rats Sprague-Dawley Regional Blood Flow Vasodilation Vasodilator Agents
When Emotions Rule Knowledge
Although emotions play an important role in human behavior and knowledge studies, knowledge management (KM) research considers them from specific angles and, to date, has lacked a comprehensive understanding of the emotions...
Published by: IGI Global Scientific Publishing
The Grizzly, September 23, 1996
Jared Rakes, Erin Gambeski, Taneille Smith, Todd Brenneman, Mark Turney, Sean Campbell, Jen Mintzer, Cristin Veit, Kerrie McKinney, Teresa Green, Joel Schofer, Brian Hamrick, Tony Palladino, Andrew Ruhf, Hera Walker
Jan 01, 0001
Internet Censorship Issue Addressed by Stefan Presser Opinions: Life in a Determinist World; Are Guns Necessary? Study Abroad to Have Fun and Learn Get Moving: A Guide to the Benefits of Exercise Anthonisen Exhibit Captures...
Ursinus College Collegeville Pennsylvania newspaper Soccer field hockey Volleyball Football Megan Larkin Berman Art Museum study abroad NRA Ryan Auch ACLU Censorship cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
E-I balance emerges naturally from continuous Hebbian learning in autonomous neural networks.
Spontaneous brain activity is characterized in part by a balanced asynchronous chaotic state. Cortical recordings show that excitatory (E) and inhibitory (I) drivings in the E-I balanced state are substantially larger than the...
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas HF Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Jan 29, 2020
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the use of probes that...
Amino Acid Sequence Animals Brain Cell Line Fluorescent Dyes Glucagon-Like Peptide-1 Receptor HEK293 Cells Human Embryonic Stem Cells Humans Islets of Langerhans Mice Mice Knockout Microscopy Fluorescence Multiphoton Models Molecular Molecular Structure Peptide Fragments Signal Transduction Tissue Distribution
Constructing Seamless Learning Through Game-Based Learning Experiences
Ioana Stefan, Ancuta Gheorghe, Antoniu Stefan, Andriani Piki, Hariklia Tsalapata, Olivier Heidmann
Oct 01, 2022
The goal of this paper is to explore how game-based experiences can be leveraged through mobile technology to activate learner engagement and achieve a seamless connection between formal and informal learning. The paper presents...
Published by: IGI Global Scientific Publishing
Social Adventure
Social environments can be challenging for people with intellectual disabilities. These challenges impact a person's social inclusion and participation in their communities. Social skills development requires training and...
Published by: IGI Global Scientific Publishing
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