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Interview with Stephen Lovegrove - OH 126
Stephen Lovegrove
Jan 01, 0001
In his December 2014 interview with Michelle Dubert-Bellrichard, Stephen Lovegrove shares his story coming to Winthrop as an "out" student recently kicked out of a religious college. Lovegrove details his perception of the...
Published by: Winthrop University
NBC's Chuck Todd Said Comedian Stephen Colbert is Making a Mockery of the Political System
Winthrop University
Jan 01, 0001
Addressing the audience on media coverage of the political campaign, Chuck Todd said comedian Stephen Colbert is making a mockery of the system. The process is a mess, Todd said, but he wondered if Colbert is trying to influence...
Published by: Winthrop University
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Small molecule inhibitors of regulators of G protein signaling (RGS) proteins
Recently, regulators of G protein signaling (RGS) proteins have emerged as potential therapeutic targets since they provide an alternative method of modulating the activity of G protein-coupled receptors, the target of so many...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Meaning at the Crossroads
Stephen Costello
Mar 16, 2022
Stephen J. Costello holds a BA, MA, and PhD in philosophy. He has addressed two parliaments—Stormont on human rights and the European Parliament in Brussels on mental health. He has twenty-five years’ experience giving seminars...
Published by: Memorial University of Newfoundland
A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase
Sam Groom, Nina K Blum, Alexandra E Conibear, Alexander Disney, Rob Hill, Stephen M Husbands, Yangmei Li, Lawrence Toll, Andrea Kliewer, Stefan Schulz, Graeme Henderson, Eamonn Kelly, Chris P Bailey
Apr 30, 2023
Background and Purpose: G protein-biased μ opioid receptor agonists have the potential to induce less receptor desensitisation and tolerance than balanced opioids. Here, we investigated if the cyclic endomorphin analogue...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase
Sam Groom, Nina K Blum, Alexandra E Conibear, Alexander Disney, Rob Hill, Stephen M Husbands, Yangmei Li, Lawrence Toll, Andrea Kliewer, Stefan Schulz, Graeme Henderson, Eamonn Kelly, Chris P Bailey
Apr 30, 2023
Background and Purpose: G protein-biased μ opioid receptor agonists have the potential to induce less receptor desensitisation and tolerance than balanced opioids. Here, we investigated if the cyclic endomorphin analogue...
The evolution of mendelian randomization for investigating drug effects.
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues investigating the associations between genetically-proxied inhibition of antihypertensive drug targets and risk of common...
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Small molecule inhibitors of regulators of G protein signaling (RGS) proteins
Recently, regulators of G protein signaling (RGS) proteins have emerged as potential therapeutic targets since they provide an alternative method of modulating the activity of G protein-coupled receptors, the target of so many...
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Dec 12, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Population studies of sporadic cerebral amyloid angiopathy and dementia
Hannah AD Keage, Roxanna O Carare, Robert P Friedland, Paul G Ince, Seth Love, James A Nicoll, Stephen B Wharton, Roy O Weller, Carol Brayne
Jun 13, 2011
BACKGROUND: Deposition of amyloid-beta (Abeta) in vessel walls of the brain as cerebral amyloid angiopathy (CAA) could be a major factor in the pathogenesis of dementia. Here we investigate the relationship between dementia and...
Deep Learning Speech Synthesis Model for Word/Character-Level Recognition in the Tamil Language
Sukumar Rajendran, Kiruba Raja, Nagarajan G., Stephen Dass A., Sandeep Kumar M., Prabhu Jayagopal
Dec 23, 2022
As electronics and the increasing popularity of social media are widely used, a large amount of text data is created at unprecedented rates. All data created cannot be read by humans, and what they discuss in their sphere of...
Published by: IGI Global Scientific Publishing
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Nov 16, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access...
Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice.
Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W Davies, Michel Goedert
Feb 12, 2023
Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Meaning at the Crossroads
Stephen Costello
Mar 16, 2022
Stephen J. Costello holds a BA, MA, and PhD in philosophy. He has addressed two parliaments—Stormont on human rights and the European Parliament in Brussels on mental health. He has twenty-five years’ experience giving seminars...
Published by: Memorial University of Newfoundland
The Lantern Vol. 44, No. 1, Fall 1977
Robert Brancatelli, Stephen M. Lange, Chris Kile, Lisa Ungrady, Len Ulan, Leslie Bechtel, Stuart Dearden, David Hoag, Ted Lis, Pamela Roediger, David Donia, Jonathan J. Zap
Jan 01, 0001
Onto My Love Saturday Midnight Michelle Today Firefly Black Midnight Bamboo Arms Caesaropapism A Day In My Life I Only For Stephen April 18, 1958 to July 15, 1977 with Emphasis on July 15 Ode to Little...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
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