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Professor Steven V Ley CBE FRS FMedSci
Steven V Ley
Sep 10, 2018
Professor Steven Ley is currently Professor of Chemistry and Director of Research at at the University of Cambridge. He is also a Fellow of Trinity College and was BP 1702 Professor of Chemistry for 21 years. Steve obtained his...
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum.
Elizabeth S Egan, Michael P Weekes, Usheer Kanjee, Jale Manzo, Ashwin Srinivasan, Christine Lomas-Francis, Connie Westhoff, Junko Takahashi, Mitsunobu Tanaka, Seishi Watanabe, Carlo Brugnara, Steven P Gygi, Yoshihiko Tani, Manoj T Duraisingh
Jun 25, 2018
The ATP-binding cassette transporter ABCB6 was recently discovered to encode the Langereis (Lan) blood group antigen. Lan null individuals are asymptomatic, and the function of ABCB6 in mature erythrocytes is not understood....
Steven Agee to Deliver Fall M.B.A. Lecture on Nov. 12
Winthrop University
Jan 01, 0001
The fall 2014 M.B.A. lecture will feature Steven C. Agee, founder, president and chief operating officer of Agee Energy, LLC. Agee is also dean and professor of economics at Oklahoma City University's Meinders School of...
Published by: Winthrop University
Compositional Proteomics
Jonathon J O'Brien, Jeremy D O'Connell, Joao A Paulo, Sanjukta Thakurta, Christopher M Rose, Michael P Weekes, Edward L Huttlin, Steven P Gygi
Feb 16, 2018
Mass spectrometry (MS) has become an accessible tool for whole proteome quantitation with the ability to characterize protein expression across thousands of proteins within a single experiment. A subset of MS quantification...
Efficient Syntheses of Biobased Terephthalic Acid, p-Toluic Acid, and p-Methylacetophenone via One-Pot Catalytic Aerobic Oxidation of Monoterpene Derived Bio-p-cymene.
An efficient elevated-pressure catalytic oxidative process (2.5 mol % Co(NO3)2, 2.5 mol % MnBr2, air (30 bar), 125 °C, acetic acid, 6 h) has been developed to oxidize p-cymene into crystalline white terephthalic acid (TA) in...
Efficient Syntheses of Biobased Terephthalic Acid, p-Toluic Acid and p-Methylacetophenone via One-Pot Catalytic Aerobic Oxidation of Monoterpene Derived bio-p-Cymene
An efficient elevated-pressure catalytic oxidative process (2.5 mol % Co(NO3)2, 2.5 mol % MnBr2, air (30 bar), 125 °C, acetic acid, 6 h) has been developed to oxidize p-cymene into crystalline white terephthalic acid (TA) in...
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Lawrence Kazak, Edward T Chouchani, Irina G Stavrovskaya, Gina Z Lu, Mark P Jedrychowski, Daniel F Egan, Manju Kumari, Xingxing Kong, Brian K Erickson, John Szpyt, Evan D Rosen, Michael P Murphy, Bruce S Kristal, Steven P Gygi, Bruce M Spiegelman
Mar 28, 2018
Brown adipose tissue (BAT) mitochondria exhibit high oxidative capacity and abundant expression of both electron transport chain components and uncoupling protein 1 (UCP1). UCP1 dissipates the mitochondrial proton motive force...
Efficient Syntheses of Biobased Terephthalic Acid, p-Toluic Acid and p-Methylacetophenone via One-Pot Catalytic Aerobic Oxidation of Monoterpene Derived bio-p-Cymene
An efficient elevated-pressure catalytic oxidative process (2.5 mol % Co(NO3)2, 2.5 mol % MnBr2, air (30 bar), 125 °C, acetic acid, 6 h) has been developed to oxidize p-cymene into crystalline white terephthalic acid (TA) in...
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Mark P Jedrychowski, Gina Z Lu, John Szpyt, Marco Mariotti, Ryan Garrity, Joao A Paulo, Devin K Schweppe, Dina Laznik-Bogoslavski, Lawrence Kazak, Michael P Murphy, Vadim N Gladyshev, Steven P Gygi, Edward T Chouchani, Bruce M Spiegelman
May 11, 2020
Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced...
Living in the Liminal: Representation of Transgender and Nonbinary Identity in 'Steven Universe'
Mads Bradley
Jan 01, 0001
An analysis of the children's animated series Steven Universe, this research takes a semiotic approach to explore anti-essentialist messages of gender identity. Atypical within the mainstream media, the cartoon expresses dynamic...
queer themes LGBTQ representation children's media cartoons Rebecca Sugar Adventure Time trans characters communication Feminist, Gender, and Sexuality Studies Film and Media Studies Lesbian, Gay, Bisexual, and Transgender Studies Television
Published by: Ursinus College
A Review of the Oxford Chichewa-English/English-Chichewa Dictionary by Steven Paas
This article reviews the Oxford Chichewa-English/English-Chichewa Dictionary compiled by Steven Paas, published in 2016 by Oxford University Press in Cape Town. Upon a review of the dictionary, a number of issues arise. The...
Published by: IGI Global Scientific Publishing
Interview with Gwen P. Howell
Gwen P. Howell
Jan 01, 0001
Interview with Gwen P. Howell, member of the South Carolina Mothers Association.
Published by: Winthrop University
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Evanna L Mills, Kerry A Pierce, Mark P Jedrychowski, Ryan Garrity, Sally Winther, Sara Vidoni, Takeshi Yoneshiro, Jessica B Spinelli, Gina Z Lu, Lawrence Kazak, Alexander S Banks, Marcia C Haigis, Shingo Kajimura, Michael P Murphy, Steven P Gygi, Clary B Clish, Edward T Chouchani
Oct 10, 2018
Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease1. Thermogenic respiration is initiated by adipocyte lipolysis through cyclic AMP-protein kinase A...
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
PSK Method for Solving Mixed and Type-4 Intuitionistic Fuzzy Solid Transportation Problems
P. Kumar
Apr 01, 2019
In this article, the author categorises the solid transportation problem (STP) under uncertain environments. He formulates the mixed and fully intuitionistic fuzzy solid transportation problems (FIFSTPs) and utilizes the...
Published by: IGI Global Scientific Publishing
Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity.
Matthew L Turnbull, Helen M Wise, Marlynne Q Nicol, Nikki Smith, Rebecca L Dunfee, Philippa M Beard, Brett W Jagger, Yvonne Ligertwood, Gareth R Hardisty, Haixia Xiao, Donald J Benton, Alice M Coburn, Joao A Paulo, Steven P Gygi, John W McCauley, Jeffery K Taubenberger, Samantha J Lycett, Michael P Weekes, Bernadette M Dutia, Paul Digard
Oct 06, 2016
A549 Cells Alleles Animals Birds Cell Line Cell Line Tumor Dogs HEK293 Cells Host Specificity Humans Influenza A virus H1N1 Subtype Influenza A virus H3N2 Subtype Influenza in Birds Influenza Human Madin Darby Canine Kidney Cells Mammals Mice Mice Inbred BALB C Orthomyxoviridae Infections Phylogeny Reassortant Viruses Viral Proteins Virulence Virus Replication
Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products
Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.
Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Oct 16, 2020
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At...
Multi-objective Bayesian optimisation of a two-step synthesis of p-cymene from crude sulphate turpentine
Perman Jorayev, Danilo Russo, Joshua D. Tibbetts, Artur M. Schweidtmann, Paul Deutsch, Steven D. Bull, Alexei A. Lapkin
Jan 16, 2022
Production of functional molecules from renewable bio-feedstocks and bio-waste has the potential to significantly reduce the greenhouse gas emissions. However, the development of such processes commonly requires invention and...
Multi-objective Bayesian optimisation of a two-step synthesis of p-cymene from crude sulphate turpentine
Perman Jorayev, Danilo Russo, Joshua D. Tibbetts, Artur M. Schweidtmann, Paul Deutsch, Steven D. Bull, Alexei A. Lapkin
Jan 16, 2022
Production of functional molecules from renewable bio-feedstocks and bio-waste has the potential to significantly reduce the greenhouse gas emissions. However, the development of such processes commonly requires invention and...
Measurement of the η<inf>c</inf>(1 S) production cross-section in p p collisions at √s=13TeV
R Aaij, CA Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, P Albicocco, J Albrecht, F Alessio, M Alexander, AA Albero, G Alkhazov, PA Cartelle, AA Alves, S Amato, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, F Archilli, P d’Argent, JA Romeu, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, JJ Back, S Baker, V Balagura, W Baldini, A Baranov, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, G Bassi, V Batozskaya, B Batsukh, A Battig, V Battista, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, LJ Bel, V Belavin, S Belin, N Beliy, V Bellee, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, E Bertholet, A Bertolin, C Betancourt, F Betti, MO Bettler, MV Beuzekom, I Bezshyiko, S Bhasin, J Bhom, MS Bieker, S Bifani, P Billoir, A Birnkraut, A Bizzeti, M Bjørn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, V Bocci, OB Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, M Boubdir
Mar 02, 2021
Using a data sample corresponding to an integrated luminosity of
$2.0\,fb^{-1}$, collected by the LHCb experiment, the production of the
$\eta_c(1S)$ state in proton-proton collisions at a centre-of-mass energy of
$\sqrt{s}=13...
Performance Characteristics of Discrete-Time Queue With Variant Working Vacations
This article analyzes an infinite buffer discrete-time single server queueing system with variant working vacations in which customers arrive according to a geometric process. As soon as the system becomes empty, the server...
Published by: IGI Global Scientific Publishing
Intrinsically p-biharmonic maps
For a compact Riemannian manifold $N$, a domain $\Omega \subset \mathbb{R}^m$ and for $p \in (1,\infty)$, we introduce an intrinsic version $E_p$ of the $p$-biharmonic energy functional for maps $u : \Omega \to N$. This requires...
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