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Results: 12
From High School to the High Chair:
We exploit an expansion of post-compulsory schooling that occurred from the late 1980s to the early 1990s to investigate the effect of education on the timing of fertility in England and Wales. We do not find a significant...
From High School to the High Chair:
We exploit an expansion of post-compulsory schooling that occurred from the late 1980s to the early 1990s to investigate the effect of education on the timing of fertility in England and Wales. We do not find a significant...
Freedom of Information (FOI) as a data collection tool for social scientists
This paper evaluates a method of generating a unique dataset that has been underused—a Freedom of Information (FOI) request. The UK’s FOI Act came into force in 2005, allowing the public to make requests of publicly held data....
/dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/subjectarea/asjc/1100/1100 name=General Agricultural and Biological Sciences /dk/atira/pure/subjectarea/asjc/1000 name=General /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Freedom of Information (FOI) as a data collection tool for social scientists
This paper evaluates a method of generating a unique dataset that has been underused—a Freedom of Information (FOI) request. The UK’s FOI Act came into force in 2005, allowing the public to make requests of publicly held data....
/dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/subjectarea/asjc/1100/1100 name=General Agricultural and Biological Sciences /dk/atira/pure/subjectarea/asjc/1000 name=General /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Mitochondrial redox and TCA cycle metabolite signaling in the heart.
Mitochondria are essential signaling organelles that regulate a broad range of cellular processes and thereby heart function. Multiple mechanisms participate in the communication between mitochondria and the nucleus that...
Riociguat reduces infarct size and post-infarct heart failure in mouse hearts
Carmen Methner, Guido Buonincontri, Chou-Hui Hu, Ana Vujic, Axel Kretschmer, Stephen Sawiak, Adrian Carpenter, Johannes-Peter Stasch, Thomas Krieg
Oct 16, 2020
AIM: Stimulation of the nitric oxide (NO)--soluble guanylate (sGC)--protein kinase G (PKG) pathway confers protection against acute ischaemia/reperfusion injury, but more chronic effects in reducing post-myocardial infarction...
Animals Biomarkers Echocardiography Guanylate Cyclase Heart Failure Hemodynamics Image Processing Computer-Assisted Magnetic Resonance Imaging Male Mice Mice Inbred C57BL Myocardial Infarction Myocardial Reperfusion Injury Positron-Emission Tomography Pyrazoles Pyrimidines Receptors Cytoplasmic and Nuclear Soluble Guanylyl Cyclase
The landscape of DNA repeat elements in human heart failure.
Syed Haider, Lina Cordeddu, Emma Robinson, Mehregan Movassagh, Lee Siggens, Ana Vujic, Mun-Kit Choy, Martin Goddard, Pietro Lio, Roger Foo
Sep 18, 2020
BACKGROUND: The epigenomes of healthy and diseased human hearts were recently examined by genome-wide DNA methylation profiling. Repetitive elements, heavily methylated in post-natal tissue, have variable methylation profiles in...
Exercise induces new cardiomyocyte generation in the adult mammalian heart.
Ana Vujic, Carolin Lerchenmüller, Ting-Di Wu, Christelle Guillermier, Charles P Rabolli, Emilia Gonzalez, Samuel E Senyo, Xiaojun Liu, Jean-Luc Guerquin-Kern, Matthew L Steinhauser, Richard T Lee, Anthony Rosenzweig
Oct 16, 2020
Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what regulates this ability or whether it can be effectively harnessed. Here...
High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
Mun-Kit Choy, Mehregan Movassagh, Lee Siggens, Ana Vujic, Martin Goddard, Ana Sánchez, Neil Perkins, Nichola Figg, Martin Bennett, Jason Carroll, Roger Foo
Jun 17, 2011
BACKGROUND: Genome-wide maps of DNA regulatory elements and their interaction with transcription factors may form a framework for understanding regulatory circuits and gene expression control in human disease, but how these...
Structural basis for potency differences between GDF8 and GDF11.
Ryan G Walker, Magdalena Czepnik, Erich J Goebel, Jason C McCoy, Ana Vujic, Miook Cho, Juhyun Oh, Senem Aykul, Kelly L Walton, Gauthier Schang, Daniel J Bernard, Andrew P Hinck, Craig A Harrison, Erik Martinez-Hackert, Amy J Wagers, Richard T Lee, Thomas B Thompson
Oct 16, 2020
BACKGROUND: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and...
Ligands myostatin Receptor structure Transforming growth factor β (TGFβ) Amino Acid Sequence Animals Bone Morphogenetic Proteins Cells Cultured Crystallography X-Ray Follistatin Genes Reporter Growth Differentiation Factors Humans Injections Intravenous Ligands Luciferases Mice Models Molecular Myoblasts Myocardium myostatin Phosphorylation Protein Binding Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type I Receptors Transforming Growth Factor beta Sequence Alignment Signal Transduction Smad Proteins Structural Homology Protein Structure-Activity Relationship
Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice.
Jason D Roh, Nicholas Houstis, Andy Yu, Bliss Chang, Ashish Yeri, Haobo Li, Ryan Hobson, Carolin Lerchenmüller, Ana Vujic, Vinita Chaudhari, Federico Damilano, Colin Platt, Daniel Zlotoff, Richard T Lee, Ravi Shah, Michael Jerosch-Herold, Anthony Rosenzweig
Oct 16, 2020
Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most...
Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.
Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Oct 16, 2020
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At...