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Impact of Coronavirus Outbreaks on Science and Society
A global event such as the COVID-19 crisis presents new, often unexpected responses that are fascinating to investigate from both scientific and social standpoints. Despite several documented similarities, the coronavirus...
Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India
Asma Munir, Narender Kumar, Suresh Babu Ramalingam, Sembulingam Tamilzhalagan, Siva Kumar Shanmugam, Alangudi Natarajan Palaniappan, Dina Nair, Padma Priyadarshini, Mohan Natarajan, Srikanth Tripathy, Uma Devi Ranganathan, Sharon J. Peacock, Julian Parkhill, Tom L. Blundell, Sony Malhotra
Jul 15, 2020
Abstract: Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis. There is an urgent need to understand the mechanisms...
Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India.
Asma Munir, Narender Kumar, Suresh Babu Ramalingam, Sembulingam Tamilzhalagan, Siva Kumar Shanmugam, Alangudi Natarajan Palaniappan, Dina Nair, Padma Priyadarshini, Mohan Natarajan, Srikanth Tripathy, Uma Devi Ranganathan, Sharon J Peacock, Julian Parkhill, Tom L Blundell, Sony Malhotra
Jul 03, 2019
Adult Allosteric Regulation Antitubercular Agents Bacterial Proteins Catalase DNA-Directed RNA Polymerases Drug Resistance Bacterial Humans india Isoniazid Machine Learning Models Molecular Mutation Mycobacterium tuberculosis Protein Conformation Protein Stability Rifampin Tuberculosis whole genome sequencing
The store-operated Ca2+ entry complex comprises a small cluster of STIM1 associated with one Orai1 channel.
Increases in cytosolic Ca2+ concentration regulate diverse cellular activities and are usually evoked by opening of Ca2+ channels in intracellular Ca2+ stores and the plasma membrane (PM). For the many signals that evoke...
Secured Transmission of Clinical Signals Using Hyperchaotic DNA Confusion and Diffusion Transform
Secured transmission of electrophysiological signals is one of the crucial requirements in telemedicine, telemonitoring, cardiovascular disease diagnosis (CVD) and telecardiology applications. The chaotic systems have good...
Published by: IGI Global Scientific Publishing
KRAP tethers IP<sub>3</sub> receptors to actin and licenses them to evoke cytosolic Ca<sup>2+</sup> signals.
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a...
HeLa Cells Cytosol Animals Humans Calcium Microfilament Proteins Actins Membrane Proteins Microscopy Fluorescence RNA Interference Protein Binding Inositol 1 4 5-Trisphosphate Receptors HEK293 Cells
Published by: Nature Communications
Adaptation in Work and Family Roles Link Support to Mental Health During a Pandemic
We address a key unresolved issue in the social support literature—how social support relates to psychological health—by examining behavioural adaptation as a mechanism through which support from work and family domains...
Adaptation Work and family social support Mental Health pandemic Covid 19 /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Cognitive functional therapy (CFT)-based rehabilitation improves clinical outcomes in UK military personnel with persistent low back pain
Introduction Low back pain (LBP) has been reported as the most common reason for presentation to the Medical Centre in the British Military, and the most common re-referral for the same condition. In 2015, the UK Defence Medical...
Free-energy-based framework for early forecasting of stem cell differentiation.
Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here, we develop an integrated stochastic modelling framework for predicting the...
What's trust got to do with it? Examining trust in leadership, psychological capital, and employee well-being in a cross-national context during Covid-19
We propose and test the idea that trust in the senior leadership team is needed to help overcome the potential widespread decrements to employee well-being resulting from the Covid-19 pandemic. Drawing on conservation of...
What's trust got to do with it? Examining trust in leadership, psychological capital, and employee well-being in a cross-national context during Covid-19
We propose and test the idea that trust in the senior leadership team is needed to help overcome the potential widespread decrements to employee well-being resulting from the Covid-19 pandemic. Drawing on conservation of...
KRAP tethers IP 3 receptors to actin and licenses them to evoke cytosolic Ca 2+ signals
Abstract: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly...
Adaptation in Work and Family Roles Link Support to Mental Health During a Pandemic
We address a key unresolved issue in the social support literature—how social support relates to psychological health—by examining behavioural adaptation as a mechanism through which support from work and family domains...
Adaptation Work and family social support Mental Health pandemic Covid 19 /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Tool Wear and Temperatures Analysis While Machining Ti-6Al-4V in MQCL-MIST Environment
Sustainable machining of titanium alloys have deficiency of studies on the built-up edges over the cutting tools and temperature correlation in minimum quantity cooling lubrication (MQCL) environment. Researchers focused on...
Published by: IGI Global Scientific Publishing
Silicone vs. Polyurethane Stent
Ureteric stents are conventionally used in daily urological practice. There is ongoing debate on the superiority of different stent materials, particularly in terms of patient tolerance. We conducted a literature review to...
Caring for people living with, and beyond, cancer
This is the final version of the article. It first appeared from the Royal College of General Practitioners via http://dx.doi.org/10.3399/bjgp15X687409
Published by: British Journal of General Practice
Free-energy-based framework for early forecasting of stem cell differentiation.
Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here, we develop an integrated stochastic modelling framework for predicting the...
Threat-Path Estimate-Based Watchword-Chunk Algorithm for Advanced Persistent Threat in the Cloud
In cloud computing, an advanced persistent threat (APT) is a cyber-attack that gains access to a network and remains undetected for some time. As well APTs have proven difficult to detect and protect, in the existing system they...
Published by: IGI Global Scientific Publishing
Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions.
Nagendra Babu Thillaiappan, Alap P Chavda, Stephen C Tovey, David L Prole, Colin W Taylor
Jun 12, 2018
IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization of IP3Rs determines both the propagation of Ca2+ signals between IP3Rs and the selective regulation of cellular responses. Here...
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors.
Vikram Babu Kasaragod, Martin Mortensen, Steven Hardwick, Ayla Wahid, Valentina Dorovykh, Dima Chirgadze, Trevor G Smart, Paul Miller
Feb 16, 2022
Time Series for Forecasting Stock Market Prices Based on Sentiment Analysis of Social Media
This paper attempts to find a relation between the public perception of a company and its stock value price. Since social media is a very powerful tool used by a lot of people to voice their opinions on the performance of a...
Published by: IGI Global Scientific Publishing
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