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The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.
Irene Escribano-Lopez, Celia Bañuls, Noelia Diaz-Morales, Francesca Iannantuoni, Susana Rovira-Llopis, Ramon Gomis, Milagros Rocha, Antonio Hernandez-Mijares, Michael P Murphy, Victor M Victor
Mar 19, 2019
BACKGROUND/AIMS: Mitochondria-targeted antioxidants such as mitoquinone (MitoQ) have demonstrated protective effects against oxidative damage in several diseases. The increase in reactive oxygen species (ROS) production during...
ER stress MitoQ MITOCHONDRIAL DYSFUNCTION Oxidative Stress Pancreatic β cells Type 2 diabetes Animals antioxidants Cell Line Tumor Endoplasmic reticulum stress Glucose Hyperglycemia Insulin-Secreting Cells Mitochondria Organophosphorus Compounds Oxidative Stress Rats Reactive Oxygen Species Signal Transduction Ubiquinone
PPR proteins - orchestrators of organelle RNA metabolism.
Pentatricopeptide repeat (PPR) proteins are important RNA regulators in chloroplasts and mitochondria, aiding in RNA editing, maturation, stabilisation or intron splicing, and in transcription and translation of organellar...
Regulation of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors and Neurotransmitters
Susana Cohen-Cory
Jan 01, 0001
Previous study indicates that in the cerebellum. Nerve Growth Factor (NGF) and NGF receptors are highly expressed during late embryonic and early postnatal development, suggesting that NGF may play an important role in...
Published by: Rockefeller University
Regions within a single epidermal cell of Drosophila can be planar polarised independently.
Planar cell polarity (PCP), the coordinated and consistent orientation of cells in the plane of epithelial sheets, is a fundamental and conserved property of animals and plants. Up to now, the smallest unit expressing PCP has...
A versatile drug delivery system targeting senescent cells.
Daniel Muñoz-Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano-Torres, Marta Paez-Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz-Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez-Máñez, Manuel Serrano
Sep 20, 2018
Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β-galactosidase activity of...
Chemotherapy Fibrosis nanomedicine palbociclib Senescence Animals Cell Survival Cellular Senescence Cytotoxins Disease Models Animal Drug Compounding Drug Delivery Systems Fluorescent Dyes Galactose Heterografts Lysosomes Mice Neoplasm Transplantation Neoplasms Oligosaccharides Piperazines Pyridines Staining and Labeling beta-Galactosidase
Brønsted Acid-Catalysed Dehydrative Substitution Reactions of Alcohols
The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable process in the development of more sustainable approaches to organic chemistry. This review outlines recent advances in Brønsted...
Balancing glycolytic flux
The increased glucose metabolism in cancer cells is required to fulfill their high energetic and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by the activation of oncogenes or loss of tumor...
The Impact of Instagram Influencer Marketing in the Restaurant Industry
When improving their offer, restaurants should also communicate adequately and draw the attention of the public, taking advantage of all available means of communication and opting for the most effective marketing techniques....
Published by: IGI Global Scientific Publishing
Meta-Analysis of the Association Between Stigma and Mental Health for People of Color
Susana Zelaya Rivera
Jan 01, 0001
The purpose of this study was to examine the presence and strength of the association between stigma and mental health for people of color in the U.S. via a meta-analytic approach.
Published by: Ursinus College
Interwoven traditions in Bell Beaker metallurgy
Julia Montes-Landa, Mercedes Murillo-Barroso, Ignacio Montero-Ruiz, Salvador Rovira-Llorens, Marcos Martinón-Torres
Sep 13, 2021
Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research...
Propelling Children’s Empathy and Friendship
Schools play a crucial role in creating supportive and safe environments, and positive feelings are key in fostering such environments. Schools as Learning Communities, based on the dialogic participation of the whole...
Susana León-Jiménez, Beatriz Villarejo-Carballido, Garazi López de Aguileta, Lídia Puigvert
Sep 06, 2020
Brønsted Acid-Catalysed Dehydrative Substitution Reactions of Alcohols
The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable process in the development of more sustainable approaches to organic chemistry. This review outlines recent advances in Brønsted...
Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols
The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release...
Arylboronic Acid Catalyzed C-Alkylation and Allylation Reactions Using Benzylic Alcohols
The arylboronic acid catalyzed dehydrative C-alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C–C bonds (19 examples, up to 98% yield) with the release...
Creation of a Digital Learning Ecosystem Using Research-Based Learning for Future Programming Teachers
Training future programming teachers requires an innovative approach. Not only students need to handle the most current trends in technologies and teaching-learning methodologies, but also they must develop the capacity and...
Published by: IGI Global Scientific Publishing
The Dynamic Connectedness Between Environmental Attention and Green Cryptocurrency
The results indicate a dynamic pattern of interconnectedness throughout history. Based on the findings, the transmission of volatility exhibited a higher magnitude during the period of COVID-19. The issue of high transmission...
Published by: IGI Global Scientific Publishing
Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C−O Bond Formation
Susana Estopina-Duran, Liam Donnelly, Euan Mclean, Bryony Hockin, Alexandra M.Z. Slawin, James Taylor
Mar 12, 2019
A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C‐O bonds. This method has been applied to the intermolecular...
Birth of a Photosynthetic Chassis
Pierre Crozet, Francisco J Navarro, Felix Willmund, Payam Mehrshahi, Kamil Bakowski, Kyle J Lauersen, Maria-Esther Pérez-Pérez, Pascaline Auroy, Aleix Gorchs Rovira, Susana Sauret-Gueto, Justus Niemeyer, Benjamin Spaniol, Jasmine Theis, Raphael Trösch, Lisa-Desiree Westrich, Konstantinos Vavitsas, Thomas Baier, Wolfgang Hübner, Felix de Carpentier, Mathieu Cassarini, Antoine Danon, Julien Henri, Christophe H Marchand, Marcello de Mia, Kevin Sarkissian, David C Baulcombe, Gilles Peltier, José-Luis Crespo, Olaf Kruse, Poul-Erik Jensen, Michael Schroda, Alison G Smith, Stéphane D Lemaire
Nov 15, 2018
Microalgae are regarded as promising organisms to develop innovative concepts based on their photosynthetic capacity that offers more sustainable production than heterotrophic hosts. However, to realize their potential as green...
Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C−O Bond Formation
Susana Estopina-Duran, Liam Donnelly, Euan Mclean, Bryony Hockin, Alexandra M.Z. Slawin, James Taylor
Mar 12, 2019
A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C‐O bonds. This method has been applied to the intermolecular...
Interwoven traditions in Bell Beaker metallurgy
Julia Montes-Landa, Mercedes Murillo-Barroso, Ignacio Montero-Ruiz, Salvador Rovira-Llorens, Marcos Martinón-Torres
Sep 09, 2021
Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research...
Published by: PLOS ONE
Interwoven traditions in Bell Beaker metallurgy
Julia Montes-Landa, Mercedes Murillo-Barroso, Ignacio Montero-Ruiz, Salvador Rovira-Llorens, Marcos Martinón-Torres
Aug 11, 2021
Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research...
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