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The regulation of lipid homeostasis is essential for normal cell physiology, and its disruption can lead to disease. Lipid droplets (LDs) are ubiquitous organelles dedicated to storing nonpolar lipids that are used for metabolic...
An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels
Sep 15, 2020
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug...
Amino Acid Sequence Animals Antifungal Agents Candida albicans Candidiasis Cytochrome P-450 Enzyme System Drug Resistance Fungal Fungal Proteins Male Membrane Proteins Mice Mice Inbred BALB C Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Sequence Homology Sterol 14-Demethylase Virulence
An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence
Michelle L. Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T. Nickels
Jul 17, 2020
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug...
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
Chao Yang, Xu Wang, Jianying Wang, Xuejie Wang, Weitao Chen, Na Lu, Symeon Siniossoglou, Zhongping Yao, Kai Liu
Dec 16, 2019
DGAT1 DGAT2 Lipin1 Axon regeneration glycerolipid phospholipid Retinal ganglion cell triglyceride Animals Axons Axotomy Cells Cultured Diacylglycerol O-Acyltransferase Female Gene Knock-In Techniques Hydrolysis Male Mice Mice Transgenic Nerve Regeneration Optic Nerve Injuries PTEN Phosphohydrolase Phosphatidate Phosphatase Phospholipids Primary Cell Culture RNA Untranslated Retinal Ganglion Cells Rod Opsins Triglycerides
Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes.
Ana Temprano, Hiroshi Sembongi, Gil-Soo Han, David Sebastián, Jordi Capellades, Cristóbal Moreno, Juan Guardiola, Martin Wabitsch, Cristóbal Richart, Oscar Yanes, Antonio Zorzano, George M Carman, Symeon Siniossoglou, Merce Miranda
Jun 21, 2016
Basic Science cell lines human Lipid Metabolism 3T3-L1 Cells Adipocytes Adipogenesis Adipose Tissue Animals Antigens Neoplasm Biomarkers Tumor Cells Cultured Cross-Sectional Studies Female Humans Lectins C-Type Lipid Metabolism lipodystrophy Male Mice Pancreatitis-Associated Proteins Phosphatidate Phosphatase RNA Small Interfering Triglycerides
CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation.
Maria Kourti, Georgia Ikonomou, Nikolaos-Nikiforos Giakoumakis, Maria Anna Rapsomaniki, Ulf Landegren, Symeon Siniossoglou, Zoi Lygerou, George Simos, Ilias Mylonis
May 14, 2015
CK1δ HIF-1 Hypoxia Lipid Droplets Lipid Metabolism Lipin1 Casein Kinase Idelta Cell Hypoxia Cell Line Cell Proliferation Fluorescence Recovery After Photobleaching HeLa Cells Humans Hypoxia-Inducible Factor 1 alpha Subunit Lipid Droplets Lipid Metabolism Phosphatidate Phosphatase Phosphorylation RNA Interference RNA Small Interfering
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization.
Antonio D Barbosa, Koini Lim, Muriel Mari, James R Edgar, Lihi Gal, Peter Sterk, Benjamin J Jenkins, Albert Koulman, David B Savage, Maya Schuldiner, Fulvio Reggiori, Philip A Wigge, Symeon Siniossoglou
Jul 08, 2019
Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl...
lipid droplet nuclear membrane NUCLEUS phospholipid triglyceride Biocatalysis Cell Compartmentation Cell Cycle Cell Nucleolus Cell Nucleus Shape Homeostasis Imaging Three-Dimensional Lipid Droplets Nuclear Envelope Phospholipids Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Triglycerides
PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D Barbosa, Che-Hsiung Liu, Ursula Weber, Marek Mlodzik, Kadri Oras, Simon Collier, M Mahmood Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, Vladimir Saudek, Benjamin J Jenkins, Albert Koulman, Marcus K Dymond, Roger C Hardie, Symeon Siniossoglou, David B Savage
Jul 17, 2018
Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells...
CCT Kennedy pathway PCYT1A lipidomics phosphatidylcholine stored curvature elastic stress Animals Cell Membrane Cell Nucleus Choline-Phosphate Cytidylyltransferase Drosophila melanogaster Elasticity Homeostasis Male Mice Mice Inbred C57BL Models Biological Nuclear Envelope Phosphatidylcholines Saccharomyces cerevisiae Stress Physiological
Emily R Rowe, Michael L Mimmack, Antonio D Barbosa, Afreen Haider, Iona Isaac, Myriam M Ouberai, Abdou Rachid Thiam, Satish Patel, Vladimir Saudek, Symeon Siniossoglou, David B Savage
Jan 13, 2016
11-mer repeat amphipathic helix lipid droplet lipodystrophy Lipolysis membrane membrane targeting monolayer perilipin phospholipid Amino Acid Sequence Animals Binding Sites Biological Transport COS Cells Carrier Proteins Chlorocebus aethiops Gene Expression Humans Hydrophobic and Hydrophilic Interactions Lipid Droplets Membrane Proteins Micelles Models Molecular Molecular Sequence Data Mutation Perilipin-1 Perilipin-2 Perilipin-3 Phosphoproteins Protein Binding Protein Interaction Domains and Motifs Protein Structure Secondary Protein Transport Recombinant Proteins Saccharomyces cerevisiae Sequence Alignment Transgenes Vesicular Transport Proteins