Search
Results: 10902
Interview with Jai Lee
Jai Lee
Jan 01, 0001
In her January 14, 2014 interview with Cody Willis, Jai Lee shares her experience as an economic major from Korea. Lee discusses the differences between Korean colleges and Winthrop. This interview was conducted for inclusion...
Published by: Winthrop University
Interview with John Lee "Bird" Ellis - OH 709
This interview was conducted by Dr. George Garrison with John Lee (Bird) Ellis for Dr. Garrison's project on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was...
Published by: Winthrop University
S.C. Association of Regional Councils Names Eddie Lee New President
Winthrop University
Jan 01, 0001
Eddie Lee '83 is also the mayor of York. Eddie Lee '83 is no stranger to local government. In addition to his duties as associate professor of history and director of history graduate studies at Winthrop University, he's also...
Published by: Winthrop University
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
Lee wave generation rates in the deep ocean
Using the world's largest data set of in situ ocean current measurements, combined with a high-resolution topography roughness data set, we use a model-assisted hierarchical clustering methodology to estimate the global lee wave...
Lee wave generation rates in the deep ocean
Using the world's largest data set of in situ ocean current measurements, combined with a high-resolution topography roughness data set, we use a model-assisted hierarchical clustering methodology to estimate the global lee wave...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
Aleks Ponjavic, James McColl, Alexander R Carr, Ana Mafalda Santos, Klara Kulenkampff, Anna Lippert, Simon J Davis, David Klenerman, Steven F Lee
Apr 11, 2019
Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this...
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.
The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in...
Animals Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Autoimmune Diseases Autoimmunity CD2 Antigens CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Humans Infections Inflammation Inflammatory Bowel Diseases Lupus Erythematosus Systemic Mice Phenotype Programmed Cell Death 1 Receptor Receptors Antigen T-Cell Receptors Interleukin-7 Transcriptome
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.
Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Oct 14, 2020
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a...
Mad2 Aneuploidy cancer biology chromosomal instability Chromosomes Genes human karyotype heterogeneity MOUSE spindle checkpoint Animals Carcinoma Hepatocellular Cell Survival chromosomal instability Disease Models Animal Hepatocytes Lymphoma T-Cell M Phase Cell Cycle Checkpoints Mad2 Proteins Mice Sequence Deletion T-Lymphocytes
Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals
Recombinant canarypox virus vectors containing human immunodeficiency virus type 1 (HIV-1) sequences are promising vaccine candidates, as they replicate poorly in human cells. However, when delivered intramuscularly the vaccines...
CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes dendritic cell HIV interferon production Poxvirus
Published by: Rockefeller University
Sims to Address Northwestern District Alumnae Association
Winthrop News Service
Jan 01, 0001
Winthrop College Alumnae Association Northwestern District consisted of the counties of Abbeville, Anderson, Greenville, Greenwood, McCormick, Oconee, and Pickens in South Carolina. The meeting took place on November 2, 1946 in...
Published by: Winthrop University
‘The Eyes of an Intellectual Vampire’
Abstract
This article reframes debate on the intersections of female aestheticism and cultural dissidence by focusing on the construction of queer masculinities at the end of the...
Frankie Dytor
May 18, 2021
TRANCE (Tumor necrosis factor [TNF]-related Activation-induced Cytokine), a new TNF family member predominantly expressed in t cells, is a dendritic cell-specific survival factor
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c-Jun N-terminal kinase (JNK) after interaction with its...
cytokine tumor necrosis factor lymphocyte proliferation dendritic cell protein determination T lymphocyte
Published by: Rockefeller University
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
Danika L Hill, Carly E Whyte, Silvia Innocentin, Jia Le Lee, James Dooley, Jiong Wang, Eddie A James, James C Lee, William W Kwok, Martin S Zand, Adrian Liston, Edward J Carr, Michelle Linterman
Nov 02, 2021
Antibody production following vaccination can provide protective immunity to subsequent infection by pathogens such as influenza viruses. However, circumstances where antibody formation is impaired after vaccination, such as in...
Antigen discrimination by T cells relies on size-constrained microvillar contact.
Edward Jenkins, Markus Körbel, Caitlin O'Brien-Ball, James McColl, Kevin Y Chen, Mateusz Kotowski, Jane Humphrey, Anna H Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F Lee, Simon J Davis, David Klenerman
Apr 17, 2023
T cells use finger-like protrusions called 'microvilli' to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a...
T-Lymphocytes microvilli Receptors Antigen T-Cell Antigens Lymphocyte Activation Signal Transduction
Published by: Nature Communications
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
|
|< |
< |
1 |