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A modified Cued Recall Test for detecting prodromal AD in adults with Down syndrome.
Sharon J Krinsky-McHale, Sigan Hartley, Christy Hom, Margaret Pulsifer, Isabel CH Clare, Benjamin L Handen, Ira T Lott, Nicole Schupf, Wayne Silverman, Alzheimer's Biomarker Consortium—Down Syndrome (ABC‐DS) Investigators
Oct 03, 2022
INTRODUCTION: The development of valid methods to diagnose prodromal Alzheimer's disease (AD) in adults with Down syndrome (DS) is one of the many goals of the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS). METHODS...
The Alzheimer's Biomarker Consortium-Down Syndrome
Benjamin L Handen, Ira T Lott, Bradley T Christian, Nicole Schupf, Sid OBryant, Mark Mapstone, Anne M Fagan, Joseph H Lee, Dana Tudorascu, Mei-Cheng Wang, Elizabeth Head, William Klunk, Beau Ances, Florence Lai, Shahid Zaman, Sharon Krinsky-McHale, Adam M Brickman, H Diana Rosas, Annie Cohen, Howard Andrews, Sigan Hartley, Wayne Silverman, Alzheimer's Biomarker Consortium‐Down Syndrome (ABC‐DS)
Aug 28, 2020
INTRODUCTION: Adults with Down syndrome (DS) are at exceptionally high risk for Alzheimer's disease (AD), with virtually all individuals developing key neuropathological features by age 40. Identifying biomarkers of AD...
Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma
Melissa E Petersen, Fan Zhang, Nicole Schupf, Sharon J Krinsky-McHale, James Hall, Mark Mapstone, Amrita Cheema, Wayne Silverman, Ira Lott, Michael S Rafii, Benjamin Handen, William Klunk, Elizabeth Head, Brad Christian, Tatiana Foroud, Florence Lai, H Diana Rosas, Shahid Zaman, Beau M Ances, Mei-Cheng Wang, Benjamin Tycko, Joseph H Lee, Sid O'Bryant, Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)
May 26, 2021
INTRODUCTION: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Cardiac Arrhythmia, CHF, and NSR Classification With NCA-Based Feature Fusion and SVM Classifier
An arrhythmia is an irregular heartbeat that causes abnormal heart rhythms. Manual analysis of electrocardiogram (ECG) signals is not sufficient to quickly detect cardiac arrhythmias. This study proposes a deep learning approach...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome
Elijah Mak, Monika Grigorova, Jessica Beresford-Webb, Maura Malpetti, Madeline Walpert, Stephanie Brown, Elizabeth Jones, Isabel Clare, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Oct 26, 2020
Positron emission tomography imaging of glucose hypometabolism and amyloid deposition are two well-established methods to evaluate preclinical changes in Alzheimer's disease and people with Down syndrome. However, the use of...
Assessment and Diagnosis of Down Syndrome Regression Disorder
Jonathan D Santoro, Lina Patel, Ryan Kammeyer, Robyn A Filipink, Grace Y Gombolay, Kathleen M Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L Santoro, Sammer M Marzouk, Mellad Khoshnood, Benjamin N Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A Stanley, Jessica S Sanders, Alison Christy, Elise M Sannar, Ruth Brown, Andrew A McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A Quinn, George T Capone, Brian Chicoine, Brian G Skotko, Michael S Rafii
Sep 02, 2022
OBJECTIVE: To develop standardization for nomenclature, diagnostic work up and diagnostic criteria for cases of neurocognitive regression in Down syndrome. BACKGROUND: There are no consensus criteria for the evaluation or...
Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome.
Hana D'Souza, Luke Mason, Kin Y Mok, Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, R Asaad Baksh, John Hardy, Andre Strydom, Michael SC Thomas, London Down Syndrome (LonDownS) Consortium
Oct 05, 2020
IMPORTANCE: Risk of Alzheimer disease (AD) is particularly high for individuals with Down syndrome (DS). The ε4 allele of the apolipoprotein E gene (APOE ε4) is associated with an additional risk for AD. In typical development...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Assessment and Diagnosis of Down Syndrome Regression Disorder
Jonathan D Santoro, Lina Patel, Ryan Kammeyer, Robyn A Filipink, Grace Y Gombolay, Kathleen M Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L Santoro, Sammer M Marzouk, Mellad Khoshnood, Benjamin N Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A Stanley, Jessica S Sanders, Alison Christy, Elise M Sannar, Ruth Brown, Andrew A McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A Quinn, George T Capone, Brian Chicoine, Brian G Skotko, Michael S Rafii
Jul 29, 2022
Objective: To develop standardization for nomenclature, diagnostic work up and diagnostic criteria for cases of neurocognitive regression in Down syndrome. Background: There are no consensus criteria for the evaluation or...
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...
Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome.
Sigan L Hartley, Victoria Fleming, Brianna Piro-Gambetti, Annie Cohen, Beau M Ances, Michael A Yassa, Adam M Brickman, Benjamin L Handen, Elizabeth Head, Mark Mapstone, Bradley T Christian, Ira T Lott, Eric Doran, Shahid Zaman, Sharon Krinsky-McHale, Fredrick A Schmitt, Christy Hom, Nicole Schupf, ABC-DS Group
Apr 08, 2022
BACKGROUND: The Down syndrome population has been disproportionately affected by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal efforts to curb the spread of COVID-19 may also have taken...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
The CD4+ T Cell Response to Human Cytomegalovirus in Healthy and Immunocompromised People
While CD8+ T cells specific for human cytomegalovirus (HCMV) have been extensively studied in both healthy HCMV seropositive carriers and patients undergoing immunosuppression, studies on the CD4+ T cell response to HCMV had...
The CD4+ T Cell Response to Human Cytomegalovirus in Healthy and Immunocompromised People.
While CD8+ T cells specific for human cytomegalovirus (HCMV) have been extensively studied in both healthy HCMV seropositive carriers and patients undergoing immunosuppression, studies on the CD4+ T cell response to HCMV had...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
Cortical atrophy and amyloid and tau deposition in Down syndrome
Concepcion Padilla, Victor Montal, Madeleine J Walpert, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Sigan L Hartley, Ann D Cohen, Dana L Tudorascu, Bradley T Christian, Benjamin L Handen, William E Klunk, Anthony J Holland, Shahid H Zaman
Apr 01, 2022
Abstract: Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at...
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
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