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The Bull-James assembly
Chiral molecules are widely used in many fields of research and so practically simple, accurate methods to measure their enantiopurities are required. This review's initial focus is on one such method, the Bull-James...
The Bull-James assembly
Chiral molecules are widely used in many fields of research and so practically simple, accurate methods to measure their enantiopurities are required. This review's initial focus is on one such method, the Bull-James...
James Darnell, Jr., 1973
The Rockefeller University
Jan 01, 0001
James E. Darnell, Jr. The origins of mRNA and the structure of the mammalian chromosome
Lecture delivered September 20, 1973
Posted with permission
Published by: Academic Press
Research priorities in mesothelioma
RJ Stephens, C Whiting, K Cowan, James Lind Alliance Mesothelioma Priority Setting Partnership Steering Committee
Aug 17, 2021
BACKGROUND: In the UK, despite the import and use of all forms of asbestos being banned more than 15 years ago, the incidence of mesothelioma continues to rise. Mesothelioma is almost invariably fatal, and more research is...
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
Quantifying persistence in the T-cell signaling network using an optically controllable antigen receptor.
T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen-presenting cell...
Henry James At Any Rate
RM Wilson
Mar 13, 2017
This essay discusses James’s prefaces to the New York Edition as instances of the development of the form of the preface for James’s critical purposes. In particular, it focuses on the deployment of James’s frequent and...
Quantifying persistence in the T‐cell signaling network using an optically controllable antigen receptor
Abstract: T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen‐presenting cell...
EMBO41 EMBO19 EMBO37 article ARTICLES Cell Signaling optogenetics Receptors T cells Transcription Factors
Published by: Molecular Systems Biology
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
Danika L Hill, Carly E Whyte, Silvia Innocentin, Jia Le Lee, James Dooley, Jiong Wang, Eddie A James, James C Lee, William W Kwok, Martin S Zand, Adrian Liston, Edward J Carr, Michelle Linterman
Nov 02, 2021
Antibody production following vaccination can provide protective immunity to subsequent infection by pathogens such as influenza viruses. However, circumstances where antibody formation is impaired after vaccination, such as in...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
T cell Allorecognition Pathways in Solid Organ Transplantation.
Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; and as self-restricted processed alloantigen...
T cell allorecognition T follicular helper cell chronic allograft vasculopathy cytotoxic CD8 T cells exhaustion Germinal Center indirect presentation Transplantation Dendritic Cells Graft Rejection Histocompatibility Antigens Class II Humans Isoantibodies Isoantigens Organ Transplantation T-Lymphocytes Cytotoxic T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Transplantation Homologous
Westminster Abbey Organist James O'Donnell Featured at Feb. 14 Recital
Winthrop University
Jan 01, 0001
Westminster Abbey Organist James O'Donnell looks forward to playing Winthrop's famed D.B. Johnson Memorial Organ for the Feb. 14 concert at Byrnes Auditorium. Tickets are $10 for the general public and $5 for those over 65 or...
Published by: Winthrop University
Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density.
John R James
May 11, 2018
The T cell antigen receptor (TCR) recognizes peptides from pathogenic proteins bound in the major histocompatibility complex (MHC). To convert this binding event into downstream signaling, the TCR complex contains immunoreceptor...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells
Inaba, K., Young, J.W., and Steinman, R.M. Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166: 182-194, 1987
Published by: The Rockefeller University Press
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses
Dendritic cells are potent antigen-presenting cells for several primary immune responses and therefore provide an opportunity for evaluating the amounts of cell-associated antigens that are required for inducing T cell-mediated...
antigen expression B lymphocyte dendritic cell human cell ymphocyte proliferation t lymphocyte activation
Published by: Rockefeller University
Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.
Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
‘The most remarkable man’
Kevin J Edwards
Apr 04, 2022
ABSTRACT: The year 2021 marked the bicentenary of the birth of James Croll (1821–1890), the self‐educated son of a crofter‐stonemason, whose life was characterised by a dizzying range of occupations and homes, poor health and...
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
Aleks Ponjavic, James McColl, Alexander R Carr, Ana Mafalda Santos, Klara Kulenkampff, Anna Lippert, Simon J Davis, David Klenerman, Steven F Lee
Apr 11, 2019
Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this...
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...
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