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Channels and gullies on the continental slope seaward of a cross-shelf trough, Labrador margin, eastern Canada
The Labrador Shelf is characterized by several cross-shelf troughs separated by intervening shallower banks. The troughs were probably occupied by fast-flowing ice streams in the Late Pleistocene. Hopedale Saddle trough has a...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Using Multicultural Children’s Literature to Address Social Issues
As the demographics of U.S. schools are changing, educators have to embrace this change and prepare students to adopt diversity and inclusivity as a means to increase students’ understanding of their peers. Not only are race and...
multicultural children's literature; racial identity; gender identity; ability identity; read alouds Education Language and Literacy Education
Published by: Digital Commons @ Texas A&M University-San Antonio
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
"Nish" Rumboldt
Douglas Dunsmore
Nov 19, 2013
This paper deals with the life and work of Ignatius "Nish" Rumboldt, a formidable force in the development of the choral art in Newfoundland and Labrador. Data has been gathered through the examination of journal and...
Published by: Faculty of Education
Increasing the Literacy Knowledge of Teacher Candidates
Educator preparation programs seek to provide teacher candidates with authentic learning experiences that support the learning process, and one means is to engage teacher candidates in service-learning. Elementary schools are...
community-university-school partnerships literacy development service-learning teacher preparation Education Language and Literacy Education
Published by: Digital Commons @ Texas A&M University-San Antonio
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The Importance of Teaching Vocabulary
This article focuses on providing teachers with the whys and hows to implement tier-two vocabulary instruction in PK-12 grade classrooms. The article examines what is meant by tier-two vocabulary words and the need for...
tier-two vocabulary word knowledge literacy development authentic literature Education Language and Literacy Education
Published by: Digital Commons @ Texas A&M University-San Antonio
A Word from Memorial's Dean of Education
Terry Piper
Nov 19, 2013
Published by: Faculty of Education
"Nish" Rumboldt
Douglas Dunsmore
Nov 19, 2013
This paper deals with the life and work of Ignatius "Nish" Rumboldt, a formidable force in the development of the choral art in Newfoundland and Labrador. Data has been gathered through the examination of journal and...
Published by: Faculty of Education
Using Authentic Literature to Enrich Young Children’s Literacy Experiences
This article focuses on the five components (phonemic awareness, phonics, fluency, vocabulary, and comprehension) needed to effectively teach children to read. Early childhood educators can teach these five skills through the...
authentic literature phonemic awareness phonics fluency Vocabulary comprehension Education Language and Literacy Education
Published by: Digital Commons @ Texas A&M University-San Antonio
Using Authentic Literature to Enrich Young Children’s Literacy Experiences
This article focuses on the five components (phonemic awareness, phonics, fluency, vocabulary, and comprehension) needed to effectively teach children to read. Early childhood educators can teach these five skills through the...
authentic literature; phonemic awareness; phonics; fluency; vocabulary; comprehension Education Language and Literacy Education
Published by: Digital Commons @ Texas A&M University-San Antonio
Increasing the Literacy Knowledge of Teacher Candidates
Educator preparation programs seek to provide teacher candidates with authentic learning experiences that support the learning process, and one means is to engage teacher candidates in service-learning. Elementary schools are...
community-university-school partnerships literacy development service-learning teacher preparation Education Language and Literacy Education
Published by: Digital Commons @ Texas A&M University-San Antonio
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
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