Search
Results: 18081
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
A Novel Framework Using Zero Shot Learning Technique for a Non-Factoid Question Answering System
Non-Factoid Question Answering (QA) is the next generation of textual QA systems, which gives passage level summaries for a natural language query, posted by the user. The main issue lies in the appropriateness of the generated...
Published by: IGI Global Scientific Publishing
Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat
We recently found block of NO synthase in rat middle cerebral artery caused spasm, associated with depolarizing oscillations in membrane potential (E-m) similar in form but faster in frequency (circa 1 Hz) to vasomotion. T-type...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Voltage-activated Ca<sup>2+</sup> channels in rat renal afferent and efferent myocytes
AIMS: Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent...
Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat
We recently found block of NO synthase in rat middle cerebral artery caused spasm, associated with depolarizing oscillations in membrane potential (E-m) similar in form but faster in frequency (circa 1 Hz) to vasomotion. T-type...
Rapid sensing of l-leucine by human and murine hypothalamic neurons
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L Evans, Florian T Merkle, Frank Reimann, Fiona M Gribble, Clemence Blouet
Apr 05, 2018
OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
Voltage-activated Ca<sup>2+</sup> channels in rat renal afferent and efferent myocytes
AIMS: Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent...
The Herschel census of infrared SEDs through cosmic time
M. Symeonidis, M. Vaccari, S. Berta, M. J. Page, D. Lutz, V. Arumugam, H. Aussel, J. Bock, A. Boselli, V. Buat, P. L. Capak, D. L. Clements, A. Conley, L. Conversi, A. Cooray, C. D. Dowell, D. Farrah, A. Franceschini, E. Giovannoli, J. Glenn, M. Griffin, E. Hatziminaoglou, H.-S. Hwang, E. Ibar, O. Ilbert, R. J. Ivison, E.~L. Floc'h, S. Lilly, J. S. Kartaltepe, B. Magnelli, G. Magdis, L. Marchetti, H. T. Nguyen, R. Nordon, B. O'Halloran, S. J. Oliver, A. Omont, A. Papageorgiou, H. Patel, C. P. Pearson, I. Pérez-Fournon, M. Pohlen, P. Popesso, F. Pozzi, D. Rigopoulou, L. Riguccini, D. Rosario, I. G. Roseboom, M. Rowan-Robinson, M. Salvato, B. Schulz, D. Scott, N. Seymour, D. L. Shupe, A. J. Smith, I. Valtchanov, L. Wang, C. K. Xu, M. Zemcov, S. Wuyts
May 21, 2013
Using Herschel data from the deepest SPIRE and PACS surveys (HerMES and PEP) in COSMOS, GOODS-S and GOODS-N, we examine the dust properties of infrared (IR)-luminous (LIR > 1010 L⊙) galaxies at 0.1 < z < 2 and determine...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Forming of Tailor-Welded Blanks Through Centerline and Offset Laser Welding
The forming of low and high strength tailor welded steel sheets into preferred three-dimensional shapes by a homogeneous distribution of plastic strain is highly difficult. In this work, the formability of tailor-welded blanks...
Published by: IGI Global Scientific Publishing
PI3K in T Cell Adhesion and Trafficking
Kristoffer H. Johansen, Dominic P. Golec, Julie H. Thomsen, Pamela L. Schwartzberg, Klaus Okkenhaug
Aug 26, 2021
PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors....
The Herschel census of infrared SEDs through cosmic time
M. Symeonidis, M. Vaccari, S. Berta, M. J. Page, D. Lutz, V. Arumugam, H. Aussel, J. Bock, A. Boselli, V. Buat, P. L. Capak, D. L. Clements, A. Conley, L. Conversi, A. Cooray, C. D. Dowell, D. Farrah, A. Franceschini, E. Giovannoli, J. Glenn, M. Griffin, E. Hatziminaoglou, H.-S. Hwang, E. Ibar, O. Ilbert, R. J. Ivison, E.~L. Floc'h, S. Lilly, J. S. Kartaltepe, B. Magnelli, G. Magdis, L. Marchetti, H. T. Nguyen, R. Nordon, B. O'Halloran, S. J. Oliver, A. Omont, A. Papageorgiou, H. Patel, C. P. Pearson, I. Pérez-Fournon, M. Pohlen, P. Popesso, F. Pozzi, D. Rigopoulou, L. Riguccini, D. Rosario, I. G. Roseboom, M. Rowan-Robinson, M. Salvato, B. Schulz, D. Scott, N. Seymour, D. L. Shupe, A. J. Smith, I. Valtchanov, L. Wang, C. K. Xu, M. Zemcov, S. Wuyts
May 21, 2013
Using Herschel data from the deepest SPIRE and PACS surveys (HerMES and PEP) in COSMOS, GOODS-S and GOODS-N, we examine the dust properties of infrared (IR)-luminous (LIR > 1010 L⊙) galaxies at 0.1 < z < 2 and determine...
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
DA Rhodes, Hung-Chang Chen, James C Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J Lehner, Thomas Herrmann, Matthias Eberl
Jul 04, 2018
Activation of human Vγ9/Vδ2 T cells by ‘phosphoantigens’ (pAg), the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) and the endogenous isoprenoid intermediate isopentenyl pyrophosphate (IPP)...
1 Underpinning research 1.1 Normal biological development and functioning 2.1 Biological and endogenous factors 2 Aetiology Generic Health Relevance ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter Subfamily G Member 1 ATP Binding Cassette Transporter Subfamily G Member 2 Antigen Presentation Antigens CD Butyrophilins Diphosphates HLA Antigens HeLa Cells Humans Interferon-gamma Lymphocyte Activation Neoplasm Proteins Protein Stability Receptors Antigen T-Cell gamma-delta T-Lymphocytes
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
Padma Akkapeddi, Rita Fragoso, Julie A Hixon, Ana Sofia Ramalho, Mariana L Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K Durum, Dario Neri, Gonçalo JL Bernardes, João T Barata
Mar 19, 2019
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer for which treatment options often result in incomplete therapeutic efficacy and long-term side-effects. Interleukin 7 (IL-7) and its receptor...
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
PI3K in T Cell Adhesion and Trafficking.
Kristoffer H Johansen, Dominic P Golec, Julie H Thomsen, Pamela L Schwartzberg, Klaus Okkenhaug
Aug 09, 2021
PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors....
CCR7 CD62L LFA-1 PI3K Adhesion integrin trafficking Animals Cell Adhesion Cell Movement Class I Phosphatidylinositol 3-Kinases Guanine Nucleotide Exchange Factors Humans Immunological Synapses Integrins Lymphocyte Function-Associated Antigen-1 Mice Primary Immunodeficiency Diseases Signal Transduction T-Lymphocytes rho-Associated Kinases
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
PI3K in T Cell Adhesion and Trafficking.
Kristoffer H Johansen, Dominic P Golec, Julie H Thomsen, Pamela L Schwartzberg, Klaus Okkenhaug
Sep 23, 2021
PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors....
Published by: Frontiers in immunology
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
|
|< |
< |
1 |