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Results: 324
Prenatal androgen exposure and children’s aggressive behavior and activity level
DA Spencer, V Pasterski, S Neufeld, V Glover, TG O'Connor, PC Hindmarsh, IA Hughes, CL Acerini, M Hines
Feb 01, 2018
Impaired platelet-dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro.
Pratima Chowdary, Colleen Hamid, David Slatter, Richard Morris, Jonathan H Foley, Keith Gomez, Edgar Brodkin, Thomas A Fox, Alex Gatt, John H McVey
Mar 31, 2020
BACKGROUND: Impaired thrombin generation (TG) in patients with acquired coagulopathy, is due to low coagulation factors and thrombocytopenia. The latter is typically treated with platelet transfusions and the former with plasma...
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages.
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Aug 26, 2021
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2...
Published by: Cell Death & Disease
The Grizzly, March 3, 2022
Layla Halterman, Chase Portaro, Alena DeAntonellis, Marie Sykes, Madison Handwerger, Vaughn DiBattista
Jan 01, 0001
Wismer Finally Steps Up Its Game Meet Dr. Amoroso-O'Connor Test Your Ursinus Knowledge Opinions: Black History Month at Ursinus Wrestling Closes a Standout Season A Solo Senior
Ursinus College Collegeville Pennsylvania newspaper dining services Diane Amoroso-O'Connor Diversity inclusion Gabby Downs Basketball wrestling cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Query-Guided Refinement and Dynamic Spans Network for Video Highlight Detection and Temporal Grounding in Online Information Systems
With the surge in online video content, finding highlights and key video segments have garnered widespread attention. Given a textual query, video highlight detection (HD) and temporal grounding (TG) aim to predict frame-wise...
Published by: IGI Global Scientific Publishing
Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes
Abstract The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youth with type 1 diabetes (T1D). Retrospective data...
Procolo Di Bonito, Francesco Maria Rosanio, Maria Loredana Marcovecchio, Valentino Cherubini, Maurizio Delvecchio, Francesca Di Candia, Dario Iafusco, Angela Zanfardino, Brunella Iovane, Claudio Maffeis, Giulio Maltoni, Carlo Ripoli, Elvira Piccinno, Claudia Anita Piona, Maria Rossella Ricciardi, Riccardo Schiaffini, Adriana Franzese, Enza Mozzillo
Jul 16, 2022
Innovation Attributes of F2F Computer-Assisted Cooperative Learning in Teaching Reading Skills
This study aimed at investigating the innovation attributes of face-to-face Computer Assisted Cooperative Learning (CACL). It employed a mixed method design as the data were collected through a survey and semi-structured...
Published by: IGI Global Scientific Publishing
A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk.
Rutger Verbeek, Federico Oldoni, R Preethi Surendran, Ailko H Zwinderman, Kay T Khaw, Erik SG Stroes, Nick J Wareham, S Matthijs Boekholdt, Geesje M Dallinga-Thie
Jul 18, 2019
BACKGROUND: Evidence on the causal link between plasma triglyceride (TG) levels and risk for cardiovascular disease (CVD) has recently emerged. Individuals with the metabolic syndrome have an increased risk for acquiring...
Description and Evaluation of an Emission-Driven and Fully Coupled Methane Cycle in UKESM1
GA Folberth, Z Staniaszek, AT Archibald, N Gedney, PT Griffiths, CD Jones, FM O’Connor, RJ Parker, AA Sellar, A Wiltshire
Jul 20, 2022
Abstract: Methane (CH4) is one of the most important trace gases in the atmosphere owing to its role as an exceedingly effective greenhouse gas and atmospheric pollutant. Better understanding of the global methane cycle and its...
Charlotte Dance Festival Welcomes Winthrop Students' Original Choreography
Winthrop University
Jan 01, 0001
The four students are Mason Diaz, Kristin Ramirez, Kristin Ward and Bridget O'Connor. Their performance will be at 6 p.m. Sunday, March 22. The Charlotte Dance Festival will feature a few familiar faces this weekend.
Published by: Winthrop University
Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.
Procolo Di Bonito, Francesco Maria Rosanio, Maria Loredana Marcovecchio, Valentino Cherubini, Maurizio Delvecchio, Francesca Di Candia, Dario Iafusco, Angela Zanfardino, Brunella Iovane, Claudio Maffeis, Giulio Maltoni, Carlo Ripoli, Elvira Piccinno, Claudia Anita Piona, Maria Rossella Ricciardi, Riccardo Schiaffini, Adriana Franzese, Enza Mozzillo
Aug 16, 2022
The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youth with type 1 diabetes (T1D). Retrospective data collected from 1323 children and adolescents...
Modest volcanic SO2 emissions from the Indonesian archipelago.
Philipson Bani, Clive Oppenheimer, Vitchko Tsanev, Bruno Scaillet, Sofyan Primulyana, Ugan Boyson Saing, Hilma Alfianti, Mita Marlia
Jul 14, 2022
Indonesia hosts the largest number of active volcanoes, several of which are renowned for climate-changing historical eruptions. This pedigree might suggest a substantial fraction of global volcanic sulfur emissions from...
Modest volcanic SO2 emissions from the Indonesian archipelago.
Philipson Bani, Clive Oppenheimer, Vitchko Tsanev, Bruno Scaillet, Sofyan Primulyana, Ugan Boyson Saing, Hilma Alfianti, Mita Marlia
Jun 11, 2022
Indonesia hosts the largest number of active volcanoes, several of which are renowned for climate-changing historical eruptions. This pedigree might suggest a substantial fraction of global volcanic sulfur emissions from...
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Jul 28, 2021
Abstract: Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which...
Exome-wide association study of plasma lipids in >300,000 individuals.
Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David Cm Liewald, Li An Lin, Allan Linneberg, Ruth JF Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas GD Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin NA Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R Van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter WF Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Charge Diabetes Working Group, EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, Joanna MM Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
May 21, 2018
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC)...
An additional bolus of rapid-acting insulin to normalise postprandial cardiovascular risk factors following high-carbohydrate high-fat meal in patients with type 1 diabetes
Aim: To evaluate an additional rapid-acting insulin bolus on postprandial lipaemia, inflammation, and pro-coagulation following high-carbohydrate high-fat feeding in people with type 1 diabetes.
Methods: Ten males with type...
Methods: Ten males with type...
An additional bolus of rapid-acting insulin to normalise postprandial cardiovascular risk factors following high-carbohydrate high-fat meal in patients with type 1 diabetes
Aim: To evaluate an additional rapid-acting insulin bolus on postprandial lipaemia, inflammation, and pro-coagulation following high-carbohydrate high-fat feeding in people with type 1 diabetes.
Methods: Ten males with type...
Methods: Ten males with type...
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages.
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Sep 08, 2021
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2...
Animals Aortic Valve Bone Marrow Transplantation Bone Morphogenetic Protein 2 Calcinosis Cell Lineage Chondrogenesis Endothelial Cells Hematopoiesis Hematopoietic Stem Cells Kaplan-Meier Estimate Mice Inbred C57BL Mice Transgenic Muscle Cells Ossification Heterotopic Osteogenesis Receptor TIE-2 Tomography X-Ray Computed
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K Peter R Nilsson, Derya R Shimshek, Philipp J Kahle, Yvonne S Eisele, Mathias Jucker
Oct 05, 2020
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to...
Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.
Florian Wilfling, Abdou Rachid Thiam, Maria-Jesus Olarte, Jing Wang, Rainer Beck, Travis J Gould, Edward S Allgeyer, Frederic Pincet, Jörg Bewersdorf, Robert V Farese, Tobias C Walther
Jun 07, 2021
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids, such as triacylglycerol (TG), as reservoirs of metabolic energy and membrane precursors. The Arf1/COPI protein machinery, known for its role in vesicle...
ER-lipid droplet connections lipid droplet Lipolysis protein targeting triglyceride synthesis ADP-Ribosylation Factor 1 Animals Biological Transport COP-Coated Vesicles Cell Line Coat Protein Complex I Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Humans LIPASE Lipid Droplets Lipolysis Mice Nanoparticles Particle Size Phospholipids RNA Interference Surface Tension Time Factors Transfection Triglycerides
Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.
Zewen Kelvin Tuong, Rebecca Fitzsimmons, Shu-Ching Mary Wang, Tae Gyu Oh, Patrick Lau, Frederik Steyn, Gethin Thomas, George EO Muscat
Sep 02, 2019
RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific...
Collagen Fibrosis Hepatomegaly obesity RORα Subcutaneous adipose Adipose Tissue Adiposity Animals Biomarkers Blood Glucose Cluster Analysis Extracellular Matrix Fibrosis Gene Expression Gene Expression Profiling Genotype Glucose Tolerance Test Hepatomegaly Humans Insulin Resistance Lipid Metabolism Lipids Liver Mice Mice Transgenic Nuclear Receptor Subfamily 1 Group F Member 1 Organ Specificity Phenotype Splenomegaly T-Lymphocyte Subsets Transgenes Weight Gain
Measuring stratigraphic congruence across trees, higher taxa and time
The congruence between the order of cladistic branching and the first appearance dates of fossil lineages can be quantified using a variety of indices. Good matching is a prerequisite for the accurate time calibration of trees...
Toward Waveguide-Based Optical Chromatography
We report analytical expressions for optical forces acting on particles inside waveguides. The analysis builds on our previously reported Fourier Transform method to obtain Beam Shape Coefficients for any beam. Here we...
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