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Why exercise builds muscles
Muscles sense internally generated and externally applied forces, responding to these in a coordinated hierarchical manner at different timescales. The center of the basic unit of the muscle, the sarcomeric M-band, is perfectly...
Separation and Selective Formation of Fullerene Adducts within an M$^{II}$$_{8}$L$_{6}$ Cage.
The self-assembly of 4-fold-symmetric porphyrins with Fe$^{II}$ or Zn$^{II}$ gave a new cubic M$^{II}$$_{8}$L$_{6}$ cage framework with electron-deficient walls. This cage bound C$_{60}$-indene or C$_{60}$-anthracene bisadducts...
Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species.
The excessive production and deposition of amyloid-β (Aβ) is one of the most important etiologies of Alzheimer's disease (AD). The interaction between Aβ and metal ions produces aberrant reactive oxygen species (ROS), which...
Online Differential Thermal Isotope Analysis of Hydration Water in Minerals by Cavity Ringdown Laser Spectroscopy.
We have developed a new method for measuring the isotopic composition (δ18O and δD) of different types of bonded water (e.g., molecular water, hydroxyl) contained in hydrated minerals by coupling a thermal gravimeter (TG) and a...
Experimental investigation of kinematic pile bending in layered soils using dynamic centrifuge modelling
This research provides an insight into the previously unexplored aspects of kinematic pile bending, especially for large-intensity earthquakes where the soil behaviour is highly non-linear. In this study, a series of...
Gigahertz measurement-device-independent quantum key distribution using directly modulated lasers
Abstract Measurement-device-independent quantum key distribution (MDI-QKD) is a technique for quantum-secured communication that eliminates all detector side-channels, although is currently...
RI Woodward, YS Lo, M Pittaluga, M Minder, TK Paraïso, M Lucamarini, ZL Yuan, AJ Shields
Apr 08, 2021
Indole
Indole is a key environmental cue that is used by many organisms. Based on its biochemistry, we suggest indole is used so universally, and by such different organisms, because it derives from the metabolism of tryptophan, a...
P53 autoantibodies in 1006 patients followed up for breast cancer.
Adult Aged Antineoplastic Combined Chemotherapy Protocols Autoantibodies Autoantigens Breast Neoplasms Chemotherapy Adjuvant Clinical Trials as Topic Cohort Studies Disease Progression Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Mastectomy Menopause Middle Aged Neoplasm Proteins Tamoxifen Treatment Outcome Tumor Suppressor Protein p53
Further Evidence for the Minifilament-eruption Scenario for Solar Polar Coronal Jets
Abstract
We examine a sampling of 23 polar-coronal-hole jets. We first identified the jets in soft X-ray (SXR) images from the X-ray telescope (XRT) on the Hinode spacecraft, over...
Cognitive impairment in Parkinson's disease
RA Lawson, AJ Yarnall, F Johnston, GW Duncan, TK Khoo, D Collerton, JP Taylor, DJ Burn, ICICLE-PD study group
Apr 12, 2018
BACKGROUND: The quality of life (QoL) of informal caregivers of people with Parkinson's disease (PD) (PwP) can be affected by the caring role. Because of cognitive symptoms and diminished activities of daily living, in addition...
On species delimitation, hybridization and population structure of cassava whitefly in Africa.
S Elfekih, WT Tay, A Polaszek, KHJ Gordon, D Kunz, S Macfadyen, TK Walsh, S Vyskočilová, J Colvin, PJ De Barro
Apr 12, 2021
The Bemisia cassava whitefly complex includes species that cause severe crop damage through vectoring cassava viruses in eastern Africa. Currently, this whitefly complex is divided into species and subgroups (SG) based on very...
Early first trimester uteroplacental flow and the progressive disintegration of spiral artery plugs
STUDY QUESTION: Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? SUMMARY ANSWER: Microvascular filling of the...
Biomarkers of cardiovascular risk across phenotypes of osteoarthritis.
SA Provan, S Rollefstad, E Ikdahl, A Mathiessen, IJ Berg, I Eeg, IB Wilkinson, CM McEniery, TK Kvien, HB Hammer, N Østerås, IK Haugen, AG Semb
Sep 06, 2019
BACKGROUND: The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to compare...
Progression of Neuropsychiatric Symptoms over Time in an Incident Parkinson's Disease Cohort (ICICLE-PD).
JK Dlay, GW Duncan, TK Khoo, CH Williams-Gray, DP Breen, RA Barker, DJ Burn, RA Lawson, AJ Yarnall
Feb 28, 2020
BACKGROUND: Cross-sectional studies have identified that the prevalence of neuropsychiatric symptoms (NPS) in Parkinson's disease (PD) ranges from 70-89%. However, there are few longitudinal studies determining the impact of NPS...
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease
MJ Firbank, AJ Yarnall, RA Lawson, GW Duncan, TK Khoo, GS Petrides, JT O’Brien, Roger Alistair Barker, RJ Maxwell, DJ Brooks, DJ Burn
Aug 16, 2017
This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1136/jnnp-2016-313918
Published by: Journal of Neurology, Neurosurgery and Psychiatry
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
TK Foo, M Tischkowitz, S Simhadri, T Boshari, N Zayed, KA Burke, SH Berman, P Blecua, N Riaz, Y Huo, YC Ding, SL Neuhausen, B Weigelt, JS Reis-Filho, WD Foulkes, B Xia
Dec 07, 2020
The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor suppression. The two BRCA proteins are linked by a...
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease
MJ Firbank, AJ Yarnall, RA Lawson, GW Duncan, TK Khoo, GS Petrides, JT O'Brien, RA Barker, RJ Maxwell, DJ Brooks, DJ Burn
Oct 14, 2016
Milk intake and incident stroke and CHD in populations of European descent
LET Vissers, I Sluijs, S Burgess, NG Forouhi, H Freisling, F Imamura, TK Nilsson, F Renström, E Weiderpass, K Aleksandrova, CC Dahm, A Perez-Cornago, MB Schulze, TYN Tong, D Aune, C Bonet, JMA Boer, H Boeing, MD Chirlaque, MI Conchi, L Imaz, S Jäger, V Krogh, C Kyrø, G Masala, O Melander, K Overvad, S Panico, MJ Sánches, E Sonestedt, A Tjønneland, I Tzoulaki, WMM Verschuren, E Riboli, NJ Wareham, J Danesh, AS Butterworth, YT van der Schouw
Oct 28, 2021
Higher milk intake has been associated with a lower stroke risk, but not with risk of CHD. Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with...
Influenza Research Database
Y Zhang, BD Aevermann, TK Anderson, DF Burke, G Dauphin, Z Gu, S He, S Kumar, CN Larsen, AJ Lee, X Li, C Macken, C Mahaffey, BE Pickett, B Reardon, T Smith, L Stewart, C Suloway, G Sun, L Tong, AL Vincent, B Walters, S Zaremba, H Zhao, L Zhou, C Zmasek, EB Klem, RH Scheuermann
Jan 24, 2017
The Hubble Space Telescope Survey of M31 Satellite Galaxies. I. RR Lyrae–based Distances and Refined 3D Geometric Structure
Abstract
We measure homogeneous distances to M31 and 38 associated stellar systems (−16.8 ≤ M
...
A Savino, DR Weisz, ED Skillman, A Dolphin, N Kallivayalil, A Wetzel, J Anderson, G Besla, M Boylan-Kolchin, JS Bullock, AA Cole, MLM Collins, MC Cooper, AJ Deason, AL Dotter, M Fardal, AMN Ferguson, TK Fritz, MC Geha, KM Gilbert, P Guhathakurta, R Ibata, MJ Irwin, M Jeon, E Kirby, GF Lewis, D Mackey, SR Majewski, N Martin, A McConnachie, E Patel, R Michael Rich, JD Simon, ST Sohn, EJ Tollerud, RP van der Marel
Oct 18, 2022
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