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Sensorimotor speech disorders in Parkinson's disease
Introduction: Dysfunction in the basal ganglia circuits is a determining factor in the physiopathology of the classic signs of Parkinson's disease (PD) and hypokinetic dysarthria is commonly related to PD. Regarding speech...
Analysis of error type and frequency in apraxia of speech among Portuguese speakers.
UNLABELLED: Most studies characterizing errors in the speech of patients with apraxia involve English language. OBJECTIVES: To analyze the types and frequency of errors produced by patients with apraxia of speech whose mother...
Behavior disorders and subjective burden among caregivers of demented patients.
Lucena Ferretti Ceres Eloah, Paulo Henrique Ferreira Bertolucci, Thaís Soares Cianciarullo Minett
Jul 29, 2019
UNLABELLED: Many patients with dementia live within the community supported by their family and friends. Majority of patient caregivers suffer from high levels of stress. METHODS: A quasi-experimental study, which compared the...
Analysis of word number and content in discourse of patients with mild to moderate Alzheimer's disease.
Juliana Onofre de Lira, Thaís Soares Cianciarullo Minett, Paulo Henrique Ferreira Bertolucci, Karin Zazo Ortiz
Jul 29, 2019
UNLABELLED: Alzheimer's disease (AD) is characterized by impairments in memory and other cognitive functions such as language, which can be affected in all aspects including discourse. A picture description task is considered an...
Assessing environmental features related to mental health
Yu-Tzu Wu, Paul Nash, Linda E Barnes, Thais Minett, Fiona E Matthews, Andy Jones, Carol Brayne
Oct 20, 2014
Metaflammasome components in the human brain
Mariko Taga, Thais Minett, John Classey, Fiona E Matthews, Carol Brayne, Paul G Ince, James AR Nicoll, Jacques Hugon, Delphine Boche, MRC CFAS
Aug 09, 2018
Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome...
Alzheimer's Disease CFAS Dementia HUMAN BRAIN metaflammasome Aged Aged 80 and over Alzheimer Disease Apolipoproteins E Cohort Studies Diabetes mellitus Type 2 Female Humans I-kappa B Kinase Immunohistochemistry Insulin Receptor Substrate Proteins MAP Kinase Kinase 4 Male Mental Status Schedule Neocortex Phosphorylation Polymorphism Genetic Risk Factors eIF-2 Kinase
TDP-43 Related Neuropathologies and Phosphorylation State
Sally Hunter, Suvi RK Hokkanen, Hannah AD Keage, Jane Fleming, Thais Minett, Tuomo Polvikoski, Kieren Allinson, Carol Brayne, Cambridge City over 75s Cohort collaboration
Apr 16, 2020
Re-examining tau-immunoreactive pathology in the population
Sally Hunter, Thais Minett, Tuomo Polvikoski, Elizabeta Mukaetova-Ladinska, Carol Brayne, Cambridge City over-75s Cohort Collaboration
Aug 27, 2015
Microglial immunophenotype in dementia with Alzheimer's pathology.
Thais Minett, John Classey, Fiona E Matthews, Marie Fahrenhold, Mariko Taga, Carol Brayne, Paul G Ince, James AR Nicoll, Delphine Boche, MRC CFAS
Aug 14, 2017
BACKGROUND: Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions...
Alzheimer’s disease Apolipoprotein E Dementia Microglia neuropathology Aged Aged 80 and over Alzheimer Disease Antigens CD Antigens Differentiation Myelomonocytic Calcium-Binding Proteins Cohort Studies Cytokines DNA-Binding Proteins Dementia Diagnosis Female HLA-DR Antigens Humans Male Mental Status Schedule Methionine Sulfoxide Reductases Microfilament Proteins Microglia Neuropsychological Tests Receptors IgG
Dementia in the older population is associated with neocortex content of serum amyloid P component.
Longitudinal diffusion tensor imaging changes in early Parkinson's disease
Thais Minett, Li Su, Elijah Mak, Guy Williams, Michael Firbank, Rachael A Lawson, Alison J Yarnall, Gordon W Duncan, Adrian M Owen, Tien K Khoo, David J Brooks, James B Rowe, Roger A Barker, David Burn, John T O'Brien
Jul 30, 2018
Assessment of cognitive disorders DTI longitudinal study mild cognitive impairment Parkinson’s disease Aged Analysis of Variance Cognition Disorders Cohort Studies Diffusion tensor imaging Female Humans Image Processing Computer-Assisted Linear Models Male Mental Status and Dementia Tests Middle Aged Neuropsychological Tests Parkinson Disease
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort.
Annabelle Chambers, Joanna J Bury, Thais Minett, Connor D Richardson, Carol Brayne, Paul G Ince, Pamela J Shaw, Claire J Garwood, Paul R Heath, Julie E Simpson, Fiona E Matthews, Stephen B Wharton
Oct 26, 2020
Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
Julie E Simpson, Paul G Ince, Thais Minett, Fiona E Matthews, Paul R Heath, Pamela J Shaw, Emily Goodall, Claire J Garwood, Laura E Ratcliffe, Carol Brayne, Magnus Rattray, Stephen B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group
Aug 09, 2018
AIMS: Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for...
Ageing brain Alzheimer's DNA damage response Dementia microarray neurones Aged 80 and over aging Alzheimer Disease Blotting Western Brain Cholesterol DNA Damage Female Humans Immunohistochemistry Laser Capture Microdissection Male Neurons Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Signal Transduction Transcriptome
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Interleukin-8-251T > A, Interleukin-1α-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease.
Alex Augusto Vendramini, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Nathali Mattiuzo Dos Reis, Thais Minett, Paulo Henrique Ferreira Bertolucci, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Diego Robles Mazzotti, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão
Aug 09, 2018
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid...
The ALPINE–ALMA [C ii] Survey
Abstract
We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field...
Lu Shen, Brian C Lemaux, Lori M Lubin, Guilin Liu, Matthieu Béthermin, Médéric Boquien, Olga Cucciati, Olivier Le Fèvre, Margherita Talia, Daniela Vergani, Gianni Zamorani, Andreas L Faisst, Michele Ginolfi, Carlotta Gruppioni, Gareth C Jones, Sandro Bardelli, Nimish Hathi, Anton M Koekemoer, Michael Romano, Daniel Schaerer, Elena Zucca, Wenjuan Fang, Ben Forrest, Roy Gal, Denise Hung, Ekta A Shah, Priti Staab, Brittany Vanderhoof, Eduardo Ibar
Aug 24, 2022
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Upgrading biogenic furans
Benzaldehyde lyase (BAL) results in an efficient biocatalyst for theumpolung carboligation of furfural, HMF, and mixtures of them,leading to blended C10–C12 platform chemicals. Subsequently, themixing and...
Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Yoann Saucereau, Thomas H Wilson, Matthew CK Tang, Martin C Moncrieffe, Steven W Hardwick, Dimitri Y Chirgadze, Sandro G Soares, Maria Jose Marcaida, Nicholas J Gay, Monique Gangloff
Sep 30, 2022
Aedes aegypti has evolved to become an efficient vector for arboviruses but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its ligand Spaetzle have undergone duplication which may allow...
Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Yoann Saucereau, Thomas H Wilson, Matthew CK Tang, Martin C Moncrieffe, Steven W Hardwick, Dimitri Y Chirgadze, Sandro G Soares, Maria Jose Marcaida, Nicholas J Gay, Monique Gangloff
Sep 02, 2022
Aedes aegypti has evolved to become an efficient vector for arboviruses but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its ligand Spaetzle have undergone duplication which may allow...
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