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Results: 176
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
Sarah R Walmsley, Cristin Print, Neda Farahi, Carole Peyssonnaux, Randall S Johnson, Thorsten Cramer, Anastasia Sobolewski, Alison M Condliffe, Andrew S Cowburn, Nicola Johnson, Edwin R Chilvers
Mar 13, 2020
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These inflammatory sites are characterized by low levels of oxygen and...
Animals Apoptosis Blotting Western Cell Survival Chemokine CCL4 Cytokines DNA Primers DNA-Binding Proteins Enzyme-Linked Immunosorbent Assay Gliotoxin Humans Hypoxia Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1 alpha Subunit Macrophage Inflammatory Proteins Mice Mice Knockout Mixed Function Oxygenases NF-kappa B p50 Subunit Neutrophils Nuclear Proteins Oligonucleotide Array Sequence Analysis Oligonucleotides Polymerase Chain Reaction Protein Binding Repressor Proteins Sesquiterpenes Transcription Factors
In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits.
Three highly conserved, multisubunit RNA polymerase (RNAP) enzymes, RNAPs I, II, and III, transcribe the eukaryotic nuclear genome (reviewed by Cramer et al. 2008, Vannini and Cramer 2012, Griesenbeck et al. 2017, Cramer 2019)....
Published by: MicroPubl Biol
Synthesis of Dyes
Faith B. Cramer
Jan 01, 0001
This 14 page thesis examines the classification and preparation of dyes.
Chromophore fast green naphthol yellow magenta eosin methyl orange Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
The return of metabolism
Anna Stincone, Alessandro Prigione, Thorsten Cramer, Mirjam MC Wamelink, Kate Campbell, Eric Cheung, Viridiana Olin-Sandoval, Nana-Maria Grüning, Antje Krüger, Mohammad Tauqeer Alam, Markus A Keller, Michael Breitenbach, Kevin M Brindle, Joshua D Rabinowitz, Markus Ralser
Sep 08, 2014
NADPH Cancer glucose 6‐phosphate dehydrogenase Glycolysis host–pathogen interactions inherited metabolic disease Metabolic Engineering metabolism of infection Metabolomics Oxidative Stress parasitic protozoa pentose phosphate pathway Stem Cells Humans Metabolic Diseases metabolism Pentose Phosphate Pathway
A topological analysis of void spaces in tungstate frameworks:assessing storage properties for the environmentally important guest molecules and ions
The identification of inorganic materials, which are able to encapsulate environmentally important small molecules or ions via host-guest interactions, is crucial for the design and development of next-generation energy sources...
A topological analysis of void spaces in tungstate frameworks:assessing storage properties for the environmentally important guest molecules and ions
The identification of inorganic materials, which are able to encapsulate environmentally important small molecules or ions via host-guest interactions, is crucial for the design and development of next-generation energy sources...
Development of a virtual sensor for the comparison of heat partitions in milling under cryogenic cooling lubrication and high-pressure cutting fluid supply
Thorsten Augspurger, Matthias Koch, Thomas Lakner, Andrea De Bartolomeis, Alborz Shokrani, Thomas Bergs
Nov 30, 2021
Manufacturing high precision and high performance parts in aerospace, automotive and medical industries often requires machining of difficult-to-cut materials such as titanium, nickel and hardened alloyed steel alloys. Low...
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows...
Animals Biomarkers Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Lineage Cell Proliferation Clone Cells Embryo Culture Techniques Embryo Implantation Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Gestational Age Laminin Mice Mice 129 Strain Mice Inbred C57BL Mice Inbred CBA Phenotype Pluripotent Stem Cells Transcription Factors
Evaluating novelty
Building on a unique, multi-source, and multi-method study of R&D projects in a leading professional service firm, we develop the argument that organizations are more likely to fund projects with intermediate levels of...
Defence against antimicrobial peptides
The Firmicutes constitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these...
Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis...
Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis...
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function.
'Pioneer' transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed...
Origin and function of the yolk sac in primate embryogenesis.
Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover...
Determination of complex subclonal structures of hematological malignancies by multiplexed genotyping of blood progenitor colonies.
Alleles Clone Cells Cluster Analysis DNA Mutational Analysis DNA Neoplasm Erythroid Precursor Cells Genotyping Techniques Granulocytes Hematologic Neoplasms High-Throughput Nucleotide Sequencing Humans Janus Kinase 2 Mutation Mutation Missense Polycythemia Vera Polymorphism Single Nucleotide Sequence Analysis DNA
Substitution of the native <i>srfA</i> promoter by constitutive P<i>veg</i> in two <i>B. subtilis </i>strains and evaluation of the effect on surfactin production
Judit Willenbacher, Teresa Mohr, Marius Henkel, Susanne Gebhard, Thorsten Mascher, Christoph Syldatk, Rudolf Hausmann
Apr 01, 2016
The genetic enhancement of Surfactin production increasingly gained attention in the last years, since relatively low product yields limit the industrial application of this biosurfactant. The natural quorum sensing regulation...
Evaluating novelty
Building on a unique, multi-source, and multi-method study of R&D projects in a leading professional service firm, we develop the argument that organizations are more likely to fund projects with intermediate levels of...
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