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Results: 164
Multi-Omics Factor Analysis-a framework for unsupervised integration of multi-omics data sets.
Ricard Argelaguet, Britta Velten, Damien Arnol, Sascha Dietrich, Thorsten Zenz, John C Marioni, Florian Buettner, Wolfgang Huber, Oliver Stegle
Oct 10, 2018
Multi-omics studies promise the improved characterization of biological processes across molecular layers. However, methods for the unsupervised integration of the resulting heterogeneous data sets are lacking. We present...
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Jul 30, 2021
Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT...
Animals Cell Death Cell Line Tumor Cell Survival Disease Progression Humans Immunohistochemistry Leukemia Lymphocytic Chronic B-Cell Mice Mice Transgenic Mitochondria Oxidative Phosphorylation Phosphatidylinositol 3-Kinases Phosphatidylinositol-3 4 5-Trisphosphate 5-Phosphatases Proto-Oncogene Proteins c-akt RNA Small Interfering RNA-seq Reactive Oxygen Species Signal Transduction Transplantation Homologous Xenograft Model Antitumor Assays
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Jul 28, 2021
Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT...
Cell Line Tumor Mitochondria Animals Mice Transgenic Humans Mice Disease Progression Reactive Oxygen Species RNA Small Interfering Transplantation Homologous Immunohistochemistry Xenograft Model Antitumor Assays Signal Transduction Cell Death Cell Survival Oxidative Phosphorylation Proto-Oncogene Proteins c-akt Leukemia Lymphocytic Chronic B-Cell Phosphatidylinositol 3-Kinases Phosphatidylinositol-3 4 5-Trisphosphate 5-Phosphatases RNA-seq
Published by: Nature Communications
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Jun 10, 2021
Abstract: Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the...
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D'Santos, Silvia Deaglio, Daniel J Hodson, Jose I Martin-Subero, Ingo Ringshausen
Nov 20, 2022
Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells...
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D'Santos, Silvia Deaglio, Daniel J Hodson, Jose I Martin-Subero, Ingo Ringshausen
Oct 24, 2022
Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells...
Development of a virtual sensor for the comparison of heat partitions in milling under cryogenic cooling lubrication and high-pressure cutting fluid supply
Thorsten Augspurger, Matthias Koch, Thomas Lakner, Andrea De Bartolomeis, Alborz Shokrani, Thomas Bergs
Nov 30, 2021
Manufacturing high precision and high performance parts in aerospace, automotive and medical industries often requires machining of difficult-to-cut materials such as titanium, nickel and hardened alloyed steel alloys. Low...
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows...
Animals Biomarkers Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Lineage Cell Proliferation Clone Cells Embryo Culture Techniques Embryo Implantation Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Gestational Age Laminin Mice Mice 129 Strain Mice Inbred C57BL Mice Inbred CBA Phenotype Pluripotent Stem Cells Transcription Factors
Evaluating novelty
Building on a unique, multi-source, and multi-method study of R&D projects in a leading professional service firm, we develop the argument that organizations are more likely to fund projects with intermediate levels of...
Defence against antimicrobial peptides
The Firmicutes constitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these...
Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis...
/dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry
Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis...
/dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry
Origin and function of the yolk sac in primate embryogenesis.
Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover...
Determination of complex subclonal structures of hematological malignancies by multiplexed genotyping of blood progenitor colonies.
Alleles Clone Cells Cluster Analysis DNA Mutational Analysis DNA Neoplasm Erythroid Precursor Cells Genotyping Techniques Granulocytes Hematologic Neoplasms High-Throughput Nucleotide Sequencing Humans Janus Kinase 2 Mutation Mutation Missense Polycythemia Vera Polymorphism Single Nucleotide Sequence Analysis DNA
Substitution of the native <i>srfA</i> promoter by constitutive P<i>veg</i> in two <i>B. subtilis </i>strains and evaluation of the effect on surfactin production
Judit Willenbacher, Teresa Mohr, Marius Henkel, Susanne Gebhard, Thorsten Mascher, Christoph Syldatk, Rudolf Hausmann
Apr 01, 2016
The genetic enhancement of Surfactin production increasingly gained attention in the last years, since relatively low product yields limit the industrial application of this biosurfactant. The natural quorum sensing regulation...
The birth of embryonic pluripotency.
Evaluating novelty
Building on a unique, multi-source, and multi-method study of R&D projects in a leading professional service firm, we develop the argument that organizations are more likely to fund projects with intermediate levels of...
Defence against antimicrobial peptides
The Firmicutes constitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these...
Evolutionary divergence of embryo implantation in primates.
Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation...
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