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Results: 56
Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal.
Mairi S Shepherd, Juan Li, Nicola K Wilson, Caroline A Oedekoven, Jiangbing Li, Miriam Belmonte, Juergen Fink, Janine CM Prick, Dean C Pask, Tina L Hamilton, Dirk Loeffler, Anjana Rao, Timm Schröder, Berthold Göttgens, Anthony R Green, David G Kent
Nov 01, 2018
WildLab
Neural mechanisms of face perception are predominantly studied in well-controlled experimental settings that involve random stimulus sequences and fixed eye positions. Although powerful, the employed paradigms are far from what...
Comparative genome analysis and gene finding in Candida species using CGOB.
Sarah L Maguire, Seán S ÓhÉigeartaigh, Kevin P Byrne, Markus S Schröder, Peadar O'Gaora, Kenneth H Wolfe, Geraldine Butler
Aug 20, 2020
The Candida Gene Order Browser (CGOB) was developed as a tool to visualize and analyze synteny relationships in multiple Candida species, and to provide an accurate, manually curated set of orthologous Candida genes for...
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.
Irene Marco-Rius, Alan J Wright, De-En Hu, Dragana Savic, Jack J Miller, Kerstin N Timm, Damian Tyler, Kevin M Brindle, Arnaud Comment
Sep 02, 2020
OBJECTIVES: To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substrate...
Probing hepatic metabolism of [2- 13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR
Irene Marco-Rius, Alan J. Wright, De-En Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment
Sep 10, 2021
RESEARCH ARTICLE Basic Science - Preclinical spectroscopy Carbon-13 Magnetic Resonance Spectroscopy Gluconeogenesis Glycolysis Liver metabolism Dynamic Nuclear Polarisation Hyperpolarisation
Published by: Springer International Publishing
Computational evaluation of the impact of incorporated nitrogen and oxygen heteroatoms on the affinity of polyaromatic ligands for carbon dioxide and methane in metal–organic frameworks
Alice Henley, Matthew J. Lennox, Timothy L. Easun, Florian Moreau, Martin Schröder, Elena Besley
Dec 08, 2016
Density functional theory is employed to explore the binding of carbon dioxide and methane in a series of isoreticular metal–organic frameworks, with particular emphasis on understanding the impact of directly incorporated...
Computational evaluation of the impact of incorporated nitrogen and oxygen heteroatoms on the affinity of polyaromatic ligands for carbon dioxide and methane in metal–organic frameworks
Alice Henley, Matthew J. Lennox, Timothy L. Easun, Florian Moreau, Martin Schröder, Elena Besley
Dec 08, 2016
Density functional theory is employed to explore the binding of carbon dioxide and methane in a series of isoreticular metal–organic frameworks, with particular emphasis on understanding the impact of directly incorporated...
Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars.
Luise Krüger, Milena Stillfried, Carolin Prinz, Vanessa Schröder, Lena Katharina Neubert, Joachim Denner
Apr 09, 2020
Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in...
Probing hepatic metabolism of [2- 13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR
Irene Marco-Rius, Alan J. Wright, De-En Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment
Feb 26, 2021
RESEARCH ARTICLE Basic Science - Preclinical spectroscopy Carbon-13 Magnetic Resonance Spectroscopy Gluconeogenesis Glycolysis Liver metabolism Dynamic Nuclear Polarisation Hyperpolarisation
Published by: Springer International Publishing
Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing
Axel T Brunger, Debanu Das, Ashley M Deacon, Joanna Grant, Thomas C Terwilliger, Randy J Read, Paul D Adams, Michael Levitt, Gunnar F Schröder
May 11, 2020
Phasing by molecular replacement remains difficult for targets that are far from the search model or in situations where the crystal diffracts only weakly or to low resolution. Here, the process of determining and refining the...
Inferring structural variant cancer cell fraction.
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre
Mar 10, 2020
We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whole-genome sequencing data. SVclone accurately determines the variant allele frequencies of both SV...
Published by: Nature Communications
Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-$^{13}$C] Dehydroascorbic Acid Reduction Using $^{13}$C Magnetic Resonance Spectroscopy
KN Timm, D-E Hu, M Williams, AJ Wright, MI Kettunen, BWC Kennedy, TJ Larkin, P Dzien, I Marco-Rius, SE Bohndiek, KM Brindle
Mar 13, 2017
Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.
Kerstin N Timm, Charith Perera, Vicky Ball, John A Henry, Jack J Miller, Matthew Kerr, James A West, Eshita Sharma, John Broxholme, Angela Logan, Dragana Savic, Michael S Dodd, Julian L Griffin, Michael P Murphy, Lisa C Heather, Damian J Tyler
Jan 18, 2021
Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers available...
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Thomas Sommermann, Tomoharu Yasuda, Jonathan Ronen, Tristan Wirtz, Timm Weber, Ulrike Sack, Rebecca Caeser, Jingwei Zhang, Xun Li, Van Trung Chu, Anna Jauch, Kristian Unger, Daniel J Hodson, Altuna Akalin, Klaus Rajewsky
Jun 15, 2020
Epstein-Barr virus (EBV) is a B cell transforming virus that causes B cell malignancies under conditions of immune suppression. EBV orchestrates B cell transformation through its latent membrane proteins (LMPs) and Epstein-Barr...
B cell lymphomagenesis EBNA Epstein-Barr virus LMP1 plasma cell differentiation Animals Cell Differentiation Cell Line Tumor Cell Transformation Viral DNA-Binding Proteins Disease Models Animal Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens FIBROBLASTS Herpesvirus 4 Human Humans Lymphoma B-Cell Mice Mice Knockout Plasma Cells Primary Cell Culture Trans-Activators Viral Matrix Proteins Viral Proteins
Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise.
Matthew Hancock, Anne D Hafstad, Adam A Nabeebaccus, Norman Catibog, Angela Logan, Ioannis Smyrnias, Synne S Hansen, Johanna Lanner, Katrin Schröder, Michael P Murphy, Ajay M Shah, Min Zhang
Feb 12, 2019
Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying...
NFE2L2 Nox4 Exercise human biology Medicine Mitochondria MOUSE Reactive Oxygen Species Animals antioxidants Mice Inbred C57BL Mice Knockout Mice Transgenic Mitochondria Myocardium Myocytes Cardiac NADPH Oxidase 4 NF-E2-Related Factor 2 Oxidative Stress Physical Conditioning Animal Physiological Phenomena Reactive Oxygen Species Signal Transduction
(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.
Piotr Dzien, Sui-Seng Tee, Mikko I Kettunen, Scott K Lyons, Timothy J Larkin, Kerstin N Timm, De-En Hu, Alan Wright, Tiago B Rodrigues, Eva M Serrao, Irene Marco-Rius, Elizabeth Mannion, Paula D'Santos, Brett WC Kennedy, Kevin M Brindle
Aug 06, 2015
Zymomonas mobilis pyruvate decarboxylase hyperpolarized [1-13C] pyruvate reporter genes Animals Carbon-13 Magnetic Resonance Spectroscopy Enzyme Activation Female Genes Reporter HEK293 Cells Humans Magnetic Resonance Imaging Mice Mice SCID Molecular Imaging pyruvate decarboxylase Pyruvic Acid Recombinant Proteins Reproducibility of Results Sensitivity and Specificity Tissue Distribution Zymomonas
Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI
Kerstin N. Timm, Charith Perera, Vicky Ball, John A. Henry, Jack J. Miller, Matthew Kerr, James A. West, Eshita Sharma, John Broxholme, Angela Logan, Dragana Savic, Michael S. Dodd, Julian L. Griffin, Michael P. Murphy, Lisa C. Heather, Damian J. Tyler
Nov 19, 2020
Abstract: Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers...
An in vitro model of early anteroposterior organization during human development.
Naomi Moris, Kerim Anlas, Susanne C van den Brink, Anna Alemany, Julia Schröder, Sabitri Ghimire, Tina Balayo, Alexander van Oudenaarden, Alfonso Martinez Arias
Jun 16, 2020
The body plan of the mammalian embryo is shaped through the process of gastrulation, an early developmental event that transforms an isotropic group of cells into an ensemble of tissues that is ordered with reference to three...
Tailoring porosity and rotational dynamics in a series of octacarboxylate metal-organic frameworks
Florian Moreau, Daniil I. Kolokolov, Alexander G. Stepanov, Timothy L. Easun, Anne Dailly, William Lewis, Alexander J. Blake, Harriott Nowell, Matthew J. Lennox, Elena Besley, Sihai Yang, Martin Schröder
Mar 21, 2017
Modulation and precise control of porosity of metal-organic frameworks (MOFs) is of critical importance to their materials function. Here we report modulation of porosity for a series of isoreticular octacarboxylate MOFs...
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