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Results: 29
Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models.
Manuela Magni, Beatrice Bossi, Paola Conforti, Maura Galimberti, Fabio Dezi, Tiziana Lischetti, Xiaoling He, Roger A Barker, Chiara Zuccato, Ira Espuny-Camacho, Elena Cattaneo
Nov 15, 2022
The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Vittoria Dickinson Bocchi, Paola Conforti, Elena Vezzoli, Dario Besusso, Claudio Cappadona, Tiziana Lischetti, Maura Galimberti, Valeria Ranzani, Raoul Jp Bonnal, Marco De Simone, Grazisa Rossetti, Xiaoling He, Kenji Kamimoto, Ira Espuny-Camacho, Andrea Faedo, Federica Gervasoni, Romina Vuono, Samantha A Morris, Jian Chen, Dan Felsenfeld, Giulio Pavesi, Roger A Barker, Massimiliano Pagani, Elena Cattaneo
May 10, 2021
Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that regulate this structure during development, we compiled a catalog of...
Co-designed mini-games for children with visual impairment
Tiziana Battistin, Nadir Dalla Pozza, Silvia Trentin, Giovanni Volpin, Andrea Franceschini, Antonio Rodà
Oct 15, 2022
UNLABELLED: Digital games aimed at improving cognitive and/or motor-sensory skills need to be carefully designed to take into account the characteristics and needs of particular categories of users. Several novel mini-games...
Lisa Ulbrich, Flores Lietta Favaloro, Laura Trobiani, Valentina Marchetti, Vruti Patel, Tiziana Pascucci, Davide Comoletti, Stefan J Marciniak, Antonella De Jaco
Jan 08, 2016
ER stress autism Molecular Chaperones neuroligin protein misfolding Unfolded Protein Response Amino Acid Sequence Animals Autistic Disorder Cell Adhesion Molecules Neuronal Endoplasmic Reticulum Eukaryotic Initiation Factor-2 Humans Membrane Proteins Mutation Nerve Tissue Proteins PC12 Cells Phosphorylation Rats Sequence Homology Amino Acid Transcription Genetic Unfolded Protein Response Up-Regulation
Bat trait, genetic and pathogen data from large-scale investigations of African fruit bats, Eidolon helvum.
Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.
Victoria R Pell, Ana-Mishel Spiroski, John Mulvey, Nils Burger, Ana SH Costa, Angela Logan, Anja V Gruszczyk, Tiziana Rosa, Andrew M James, Christian Frezza, Michael P Murphy, Thomas Krieg
Sep 10, 2018
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted and then restored, and underlies many disorders, notably myocardial infarction and stroke. While reperfusion of ischemic tissue is essential for...
ischemia-reperfusion injury Ischemic preconditioning Mitochondria Succinate Analysis of Variance Animals Disease Models Animal Energy Metabolism Ischemic Preconditioning Myocardial Male Metabolome Metabolomics Mice Mitochondria Myocardial Reperfusion Injury Myocardium Oxidation-Reduction Reactive Oxygen Species Succinic Acid
Lipomatosis Incidence and Characteristics in an Italian Cohort of Mitochondrial Patients.
Olimpia Musumeci, Emanuele Barca, Costanza Lamperti, Serenella Servidei, Giacomo Pietro Comi, Maurizio Moggio, Tiziana Mongini, Gabriele Siciliano, Massimiliano Filosto, Elena Pegoraro, Guido Primiano, Dario Ronchi, Liliana Vercelli, Daniele Orsucci, Luca Bello, Massimo Zeviani, Michelangelo Mancuso, Antonio Toscano
May 09, 2019
Lipomas have often been associated with mtDNA mutations and were mainly observed in patients with mutation in mitochondrial tRNAlysine which is also the most frequent mutation associated with MERRF. Up to date, no systematic...
The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Mariaelena Repici, Mahdieh Hassanjani, Daniel C Maddison, Pedro Garção, Sara Cimini, Bhavini Patel, Éva M Szegö, Kornelis R Straatman, Kathryn S Lilley, Tiziana Borsello, Tiago F Outeiro, Lia Panman, Flaviano Giorgini
Mar 25, 2019
Mutations in the gene encoding DJ-1 are associated with autosomal recessive forms of Parkinson's disease (PD). DJ-1 plays a role in protection from oxidative stress, but how it functions as an "upstream" oxidative stress sensor...
Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature.
Maria-Anna Trapotsi, Elizabeth Mouchet, Guy Williams, Tiziana Monteverde, Karolina Juhani, Riku Turkki, Filip Miljković, Anton Martinsson, Lewis Mervin, Kenneth R Pryde, Erik Müllers, Ian Barrett, Ola Engkvist, Andreas Bender, Kevin Moreau
Aug 06, 2022
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.
Concetta D'Ambrosio, Jessica Erriquez, Maddalena Arigoni, Sonia Capellero, Gloria Mittica, Eleonora Ghisoni, Fulvio Borella, Dionyssios Katsaros, Silvana Privitera, Marisa Ribotta, Elena Maldi, Giovanna Di Nardo, Enrico Berrino, Tiziana Venesio, Riccardo Ponzone, Marco Vaira, Douglas Hall, Mercedes Jimenez-Linan, Anna L Paterson, Raffaele A Calogero, James D Brenton, Giorgio Valabrega, Maria Flavia Di Renzo, Martina Olivero
Mar 10, 2020
Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation. We fully characterized 43 lines of...
PDX derived tumour cells PI3K PIK3R1 Patient-Derived xenografts ovarian cancer Animals Carcinoma Ovarian Epithelial Cell Line Tumor Class Ia Phosphatidylinositol 3-Kinase Cystadenocarcinoma Serous Female Heterografts Humans Mice Mice Inbred NOD Mice SCID Molecular Targeted Therapy Mutation Neoplasm Grading Ovarian Neoplasms Random Allocation
Impact of age on sorafenib outcomes in hepatocellular carcinoma
Saur Hajiev, Elias Allara, Leila Motedayеn Aval, Tadaaki Arizumi, Dominik Bettinger, Mario Pirisi, Lorenza Rimassa, Tiziana Pressiani, Nicola Personeni, Laura Giordano, Masatoshi Kudo, Robert Thimme, Joong-Won Park, Tamar H Taddei, David E Kaplan, Ramya Ramaswami, David J Pinato, Rohini Sharma
Oct 19, 2021
BACKGROUND: There is no consensus on the effect of sorafenib dosing on efficacy and toxicity in elderly patients with hepatocellular carcinoma (HCC). Older patients are often empirically started on low-dose therapy with the aim...
Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia.
Antonella Padella, Giorgia Simonetti, Giulia Paciello, George Giotopoulos, Carmen Baldazzi, Simona Righi, Martina Ghetti, Anna Stengel, Viviana Guadagnuolo, Rossella De Tommaso, Cristina Papayannidis, Valentina Robustelli, Eugenia Franchini, Andrea Ghelli Luserna di Rorà, Anna Ferrari, Maria Chiara Fontana, Samantha Bruno, Emanuela Ottaviani, Simona Soverini, Clelia Tiziana Storlazzi, Claudia Haferlach, Elena Sabattini, Nicoletta Testoni, Ilaria Iacobucci, Brian JP Huntly, Elisa Ficarra, Giovanni Martinelli
Dec 19, 2019
Approximately 18% of acute myeloid leukemia (AML) cases express a fusion transcript. However, few fusions are recurrent across AML and the identification of these rare chimeras is of interest to characterize AML patients. Here...
Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure.
Elangovan Boobalan, Amy H Thompson, Ramakrishna P Alur, David M McGaughey, Lijin Dong, Grace Shih, Emile R Vieta-Ferrer, Ighovie F Onojafe, Vijay K Kalaskar, Gavin Arno, Andrew J Lotery, Bin Guan, Chelsea Bender, Omar Memon, Lauren Brinster, Clement Soleilhavoup, Lia Panman, Tudor C Badea, Andrea Minella, Antonio Jacobo Lopez, Sara M Thomasy, Ala Moshiri, Delphine Blain, Robert B Hufnagel, Tiziana Cogliati, Kapil Bharti, Brian P Brooks
Dec 08, 2022
External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort
Tim Rattay, Petra Seibold, Miguel E. Aguado-Barrera, Manuel Altabas, David Azria, Gillian C. Barnett, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Charlotte E. Coles, Alison M. Dunning, Rebecca M. Elliott, Marie-Pierre Farcy Jacquet, Sara Gutiérrez-Enríquez, Kerstie Johnson, Anusha Müller, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Dirk de Ruysscher, Maria C. de Santis, Elena Sperk, Hilary Stobart, R. Paul Symonds, Begoña Taboada-Valladares, Ana Vega, Liv Veldeman, Adam J. Webb, Catharine M. West, Riccardo Valdagni, Christopher J. Talbot, REQUITE consortium
Nov 13, 2020
Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of...
Development and Optimization of a Machine-Learning Prediction Model for Acute Desquamation After Breast Radiation Therapy in the Multicenter REQUITE Cohort.
Mahmoud Aldraimli, Sarah Osman, Diana Grishchuck, Samuel Ingram, Robert Lyon, Anil Mistry, Jorge Oliveira, Robert Samuel, Leila EA Shelley, Daniele Soria, Miriam V Dwek, Miguel E Aguado-Barrera, David Azria, Jenny Chang-Claude, Alison Dunning, Alexandra Giraldo, Sheryl Green, Sara Gutiérrez-Enríquez, Carsten Herskind, Hans van Hulle, Maarten Lambrecht, Laura Lozza, Tiziana Rancati, Victoria Reyes, Barry S Rosenstein, Dirk de Ruysscher, Maria C de Santis, Petra Seibold, Elena Sperk, R Paul Symonds, Hilary Stobart, Begoña Taboada-Valadares, Christopher J Talbot, Vincent JL Vakaet, Ana Vega, Liv Veldeman, Marlon R Veldwijk, Adam Webb, Caroline Weltens, Catharine M West, Thierry J Chaussalet, Tim Rattay, REQUITE consortium
Jul 02, 2022
PURPOSE: Some patients with breast cancer treated by surgery and radiation therapy experience clinically significant toxicity, which may adversely affect cosmesis and quality of life. There is a paucity of validated clinical...
Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort.
Adam J Webb, Emily Harper, Tim Rattay, Miguel E Aguado-Barrera, David Azria, Celine Bourgier, Muriel Brengues, Erik Briers, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Alessandro Cicchetti, Dirk de Ruysscher, Maria Carmen De Santis, Alison M Dunning, Rebecca M Elliott, Laura Fachal, Antonio Gómez-Caamaño, Sara Gutiérrez-Enríquez, Kerstie Johnson, Ramón Lobato-Busto, Sarah L Kerns, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S Rosenstein, Petra Seibold, Alejandro Seoane, Paloma Sosa-Fajardo, Elena Sperk, Begoña Taboada-Valladares, Riccardo Valdagni, Ana Vega, Liv Veldeman, Tim Ward, Catharine M West, R Paul Symonds, Christopher J Talbot, REQUITE consortium
Oct 24, 2022
BACKGROUND: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time...
A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort.
Michela Carlotta Massi, Francesca Gasperoni, Francesca Ieva, Anna Maria Paganoni, Paolo Zunino, Andrea Manzoni, Nicola Rares Franco, Liv Veldeman, Piet Ost, Valérie Fonteyne, Christopher J Talbot, Tim Rattay, Adam Webb, Paul R Symonds, Kerstie Johnson, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Dirk de Ruysscher, Ben Vanneste, Evert Van Limbergen, Ananya Choudhury, Rebecca M Elliott, Elena Sperk, Carsten Herskind, Marlon R Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, Alessandro Cicchetti, David Azria, Marie-Pierre Farcy Jacquet, Barry S Rosenstein, Richard G Stock, Kayla Collado, Ana Vega, Miguel Elías Aguado-Barrera, Patricia Calvo, Alison M Dunning, Laura Fachal, Sarah L Kerns, Debbie Payne, Jenny Chang-Claude, Petra Seibold, Catharine ML West, Tiziana Rancati
Dec 04, 2020
Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this...
External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort.
Tim Rattay, Petra Seibold, Miguel E Aguado-Barrera, Manuel Altabas, David Azria, Gillian C Barnett, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Charlotte E Coles, Alison M Dunning, Rebecca M Elliott, Marie-Pierre Farcy Jacquet, Sara Gutiérrez-Enríquez, Kerstie Johnson, Anusha Müller, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S Rosenstein, Dirk de Ruysscher, Maria C de Santis, Elena Sperk, Hilary Stobart, R Paul Symonds, Begoña Taboada-Valladares, Ana Vega, Liv Veldeman, Adam J Webb, Catharine M West, Riccardo Valdagni, Christopher J Talbot, REQUITE consortium
Nov 23, 2020
Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of...
A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort
Michela Carlotta Massi, Francesca Gasperoni, Francesca Ieva, Anna Maria Paganoni, Paolo Zunino, Andrea Manzoni, Nicola Rares Franco, Liv Veldeman, Piet Ost, Valérie Fonteyne, Christopher J. Talbot, Tim Rattay, Adam Webb, Paul R. Symonds, Kerstie Johnson, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Dirk de Ruysscher, Ben Vanneste, Evert Van Limbergen, Ananya Choudhury, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon R. Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, Alessandro Cicchetti, David Azria, Marie-Pierre Farcy Jacquet, Barry S. Rosenstein, Richard G. Stock, Kayla Collado, Ana Vega, Miguel Elías Aguado-Barrera, Patricia Calvo, Alison M. Dunning, Laura Fachal, Sarah L. Kerns, Debbie Payne, Jenny Chang-Claude, Petra Seibold, Catharine M. L. West, Tiziana Rancati
Oct 29, 2020
Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this...
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K Daly, Bernhard Scheiner, Katharina Pomej, Martha M Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N Marche, Thomas Decaens, David J Pinato, Roland Rad, Joachim C Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M Llovet, Mathias Heikenwalder
May 05, 2021
Hepatocellular carcinoma (HCC) can have viral or non-viral causes1-5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of...
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D’Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Apr 14, 2021
Abstract: Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based...
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