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Results: 509
UK quantitative WB-DWI technical workgroup
Anna Barnes, Roberto Alonzi, Matthew Blackledge, Geoff Charles-Edwards, David J Collins, Gary Cook, Glynn Coutts, Vicky Goh, Martin Graves, Charles Kelly, Dow-Mu Koh, Hazel McCallum, Marc E Miquel, James O'Connor, Anwar Padhani, Rachel Pearson, Andrew Priest, Andrea Rockall, James Stirling, Stuart Taylor, Nina Tunariu, Jan van der Meulen, Darren Walls, Jessica Winfield, Shonit Punwani
Aug 29, 2018
OBJECTIVE: Application of whole body diffusion-weighted MRI (WB-DWI) for oncology are rapidly increasing within both research and routine clinical domains. However, WB-DWI as a quantitative imaging biomarker (QIB) has...
Localising occult prostate cancer metastasis with advanced imaging techniques (LOCATE trial)
Sola Adeleke, Arash Latifoltojar, Harbir Sidhu, Myria Galazi, Taimur T Shah, Joey Clemente, Reena Davda, Heather Ann Payne, Manil D Chouhan, Maria Lioumi, Sue Chua, Alex Freeman, Manuel Rodriguez-Justo, Anthony Coolen, Sachin Vadgama, Steve Morris, Gary J Cook, Jamshed Bomanji, Manit Arya, Simon Chowdhury, Simon Wan, Athar Haroon, Tony Ng, Hashim Uddin Ahmed, Shonit Punwani
Feb 24, 2020
BACKGROUND: Accurate whole-body staging following biochemical relapse in prostate cancer is vital in determining the optimum disease management. Current imaging guidelines recommend various imaging platforms such as computed...
Brachytherapy Cost comparison cost-effectiveness economic evaluation Magnetic Resonance Imaging positron emission tomography prostate cancer Radiotherapy Recurrence Cost-Benefit Analysis ErbB Receptors Exosomes Humans Magnetic Resonance Imaging Male Neoplasm Metastasis Neoplasm Recurrence Local Prospective Studies Prostatic Neoplasms Sensitivity and Specificity Whole Body Imaging
Genetically improved BarraCUDA.
BACKGROUND: BarraCUDA is an open source C program which uses the BWA algorithm in parallel with nVidia CUDA to align short next generation DNA sequences against a reference genome. Recently its source code was optimised using...
Factors affecting repeated cessations of injecting drug use and relapses during the entire injecting career among the Edinburgh Addiction Cohort.
Yang Xia, Shaun Seaman, Matthew Hickman, John Macleod, Roy Robertson, Lorraine Copeland, Jim McKenzie, Daniela De Angelis
Jun 14, 2018
BACKGROUND AND AIMS: Injecting drug use is a chronic condition, with people who inject drugs (PWID) typically experiencing repeated cessations and relapses during their injection careers. We characterize patterns of ceasing and...
Cessation Heroin addiction Opiate substitution treatment Random effects model recurrent events Relapse Adolescent Adult Age Factors Behavior Addictive Child Chronic Disease Cohort Studies Female Humans Male Opiate Substitution Treatment Recurrence Scotland Substance Abuse Intravenous Time Factors Young Adult
Patient preferences for whole-body MRI or conventional staging pathways in lung and colorectal cancer
Anne Miles, Stuart A Taylor, Ruth EC Evans, Steve Halligan, Sandy Beare, John Bridgewater, Vicky Goh, Sam Janes, Neil Navani, Alf Oliver, Alison Morton, Andrea Rockall, Caroline S Clarke, Stephen Morris, STREAMLINE investigators
Feb 24, 2020
OBJECTIVES: To determine the importance placed by patients on attributes associated with whole-body MRI (WB-MRI) and standard cancer staging pathways and ascertain drivers of preference. METHODS: Patients recruited to two...
Cancer Magnetic Resonance Imaging Patient Preference positron emission tomography Tomography X-Ray Computed Adult Aged Colorectal Neoplasms Female Humans Lung Neoplasms Magnetic Resonance Imaging Male Middle Aged Neoplasm Staging Patient Preference Positron Emission Tomography Computed Tomography Positron-Emission Tomography Prospective Studies Regression Analysis Surveys and Questionnaires Tomography X-Ray Computed Whole Body Imaging
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 08, 2020
INTRODUCTION: Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
Measuring the conservation attitudes of local communities towards the African elephant Loxodonta africana, a flagship species in the Mara ecosystem.
Gaining insights into local people's views, values and preferences for different conservation management options are increasingly gaining importance among conservationists and decision-makers. This can be achieved through the...
A Question of Trust
Tobias Eberwein
Feb 16, 2018
Narrative forms of journalistic reporting are traded as a sheet anchor in many newsrooms, as editors hope that they could brave the never-ending storm of the media crisis. But how does journalistic storytelling evolve from...
Communication Studies Media and Communications Digital Communications Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
The Ursinus Weekly, November 8, 1907
Harvey B. Danehower, Jean Leroy Roth, Eva May Thompson, Harold Dean Steward, John Ellis Tobias
Jan 01, 0001
To tender the call Letter for the alumni Schubert string quartet Football Society Alumni notes Locals Seminary notes Literary Supplement: The Lack of Appreciation of the Beautiful; A Defense of American Poetry; The...
Ursinus College Collegeville Pennsylvania newspaper Albert Edwin Keigwin Football YMCA Schaff literary society Zwinglian literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Anxiety at 13 and its effect on pain, pain-related anxiety, and pain-related disability at 17
The aim of the present study was to investigate the influence of anxiety at 13 years of age on the presence of chronic pain, pain-related anxiety, and pain-related disability at 17 years of age in a large longitudinal cohort....
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers
Costanza Paoletti, Gaia Schiavon, Emily M Dolce, Elizabeth P Darga, T Hedley Carr, Joseph Geradts, Matthias Hoch, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Shethah Morgan, Parul Patel, Vicky Rowlands, Nitharsan Sathiyayogan, Kimberly Aung, Erika Hamilton, Manish Patel, Anne Armstrong, Komal Jhaveri, Seock-Ah Im, Nadia Iqbal, Fouziah Butt, Caroline Dive, Elizabeth A Harrington, J Carl Barrett, Richard Baird, Daniel F Hayes
Nov 16, 2018
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive metastatic breast cancers include, among others, ER loss and acquired activating mutations in the ligand-binding domain of the ER...
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 02, 2020
INTRODUCTION:Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer.
Nicolas J Walker, Mamunur Rashid, Shirong Yu, Helen Bignell, Casper K Lumby, Carmen M Livi, Kate Howell, David J Morley, Sandro Morganella, Daniel Barrell, Shabhonam Caim, Walraj Gosal, Jens Füllgrabe, Thomas J Charlesworth, Louella Vasquez, Miika Ahdesmäki, Jordan Eizenga, Parul Prabhat, Vitali Proutski, Marie Laurie Murat-Onana, Catherine J Greenwood, Lisa Kirkwood, Meeta Maisuria-Armer, Mengjie Li, Emma Coats, Victoria Winfield, Lachlan MacBean, Toby Stock, Alice Tomé-Fernandez, Yat Chan, Nasir Sheikh, Paula Golder, Michael Steward, Tobias WB Ost, Douglas Stewart, Albert Vilella, Mojtaba Noursalehi, Benedict Paten, Debora Lucarelli, Joanne Mason, Gareth Ridge, Jason Mellad, Suman Shirodkar, Shankar Balasubaramanian, Joanna D Holbrook
Oct 04, 2022
Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we...
The Ursinus Weekly, November 1, 1907
Harvey B. Danehower, Evelyn A. Neff, Eva May Thompson, Harold Dean Steward, Victor J. Abel, John Ellis Tobias
Jan 01, 0001
Phantom party at Olevian Football Historical Political meeting The Schubert string quartette Editorial: Smiles Society Personals Seminary notes College world Alumni notes Literary Supplement: The lack of appreciation...
Ursinus College Collegeville Pennsylvania newspaper Football Halloween YMCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Anxiety at 13 and its effect on pain, pain-related anxiety, and pain-related disability at 17
The aim of the present study was to investigate the influence of anxiety at 13 years of age on the presence of chronic pain, pain-related anxiety, and pain-related disability at 17 years of age in a large longitudinal cohort....
Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression.
Meiosis and oocyte maturation are tightly regulated processes. The meiosis arrest female 1 (MARF1) gene is essential for meiotic progression in animals; however, its detailed function remains unclear. In this study, we examined...
Amino Acid Motifs Animals Cell Cycle Proteins Cell Differentiation Cell Fusion Conserved Sequence Cyclin B Down-Regulation Drosophila Proteins Drosophila melanogaster Female Gene Expression Regulation Meiosis Mutant Proteins Mutation Oocytes Oogenesis Ovary Protein Binding RNA Messenger RNA-Binding Proteins Thioredoxins
Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK
David Glynn, Judith Bliss, Adrian Murray Brunt, Charlotte E Coles, Duncan Wheatley, Joanne S Haviland, Anna M Kirby, Francesco Longo, Rita Faria, John R Yarnold, Susan Griffin
Jan 06, 2023
PURPOSE: We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in the UK. In a subgroup of patients eligible for all modalities, we compared whole-breast (WB) and partial breast (PB)...
North Atlantic ocean circulation and abrupt climate change during the last glaciation.
The most recent ice age was characterized by rapid and hemispherically asynchronous climate oscillations, whose origin remains unresolved. Variations in oceanic meridional heat transport may contribute to these repeated climate...
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Åsa Sjöling, Ann-Mari Svennerholm
Jun 25, 2018
The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea. Although 22 antigenically different colonization factors (CFs) have been identified and characterized in...
Co-complex protein membership evaluation using Maximum Entropy on GO ontology and InterPro annotation.
Irina M Armean, Kathryn S Lilley, Matthew WB Trotter, Nicholas CV Pilkington, Sean B Holden
Feb 12, 2018
MOTIVATION: Protein-protein interactions (PPI) play a crucial role in our understanding of protein function and biological processes. The standardization and recording of experimental findings is increasingly stored in...
Random Structure Searching with Orbital-Free Density Functional Theory.
William C Witt, Benjamin WB Shires, Chuin Wei Tan, Wojciech J Jankowski, Chris J Pickard
Jan 29, 2021
The properties of a material depend on how its atoms are arranged, and predicting these arrangements from first principles is a longstanding challenge. Orbital-free density functional theory provides a quantum-mechanical model...
Cost-effectiveness of 5 fraction and partial breast radiotherapy for early breast cancer in the UK
David Glynn, Judith Bliss, Adrian Murray Brunt, Charlotte E Coles, Duncan Wheatley, Joanne S Haviland, Anna M Kirby, Francesco Longo, Rita Faria, John R Yarnold, Susan Griffin
Dec 18, 2022
PURPOSE: We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in the UK. In a subgroup of patients eligible for all modalities, we compared whole-breast (WB) and partial breast (PB)...
Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.
Celia L Gregson, Kenneth ES Poole, Eugene V McCloskey, Emma L Duncan, Jörn Rittweger, William D Fraser, George Davey Smith, Jonathan H Tobias
Oct 06, 2015
Adaptor Proteins Signal Transducing Adult Aged Aged 80 and over Bone Density Bone Morphogenetic Proteins Case-Control Studies Female Genetic Markers Humans Hyperostosis Low Density Lipoprotein Receptor-Related Protein-5 Male Middle Aged Mutation Osteochondrodysplasias Syndactyly United Kingdom Young Adult
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