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Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Nov 30, 2020
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and...
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekaterina Petrovich-Kopitman, Tomasz Janus, Nathali Kaushansky, Tao Cheng, Irit Sagi, Mariusz Z Ratajczak, Simón Méndez-Ferrer, John E Dick, Regina P Markus, Tsvee Lapidot
Nov 20, 2018
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production...
TNF Bone Marrow differentiation and egress hematopoietic stem and progenitor cells light and darkness maintenance and retention melatonin Norepinephrine stem cell repopulation potential vascular permeability Animals Cell Differentiation Cells Cultured Darkness Epigenesis Genetic Hematopoietic Stem Cells LIGHT Mice Mice Inbred C57BL Transcription Factors