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Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.
Diana Zabini, Elise Granton, Yijie Hu, Maria Zena Miranda, Ulrike Weichelt, Sandra Breuils Bonnet, Sébastien Bonnet, Nicholas W Morrell, Kim A Connelly, Steeve Provencher, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Andras Kapus, Wolfgang M Kuebler
Jan 04, 2019
RATIONALE: Vascular remodeling in pulmonary arterial hypertension (PAH) results from smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of BMPR-II (bone morphogenetic protein receptor 2) signaling and...
SMAD3 myocardin-related transcription factor pulmonary arterial hypertension Vascular Remodeling Animals Cell Movement Cell Proliferation Disease Models Animal Down-Regulation Humans Hypertension Pulmonary Male Muscle Cells Random Allocation Rats Rats Sprague-Dawley Sensitivity and Specificity Smad3 Protein Transcription Factors Transfection Transforming Growth Factor beta Vascular Remodeling
Double Higgs boson production and Higgs self-coupling extraction at CLIC
Abstract: The Compact Linear Collider (CLIC) is a future electron–positron collider that will allow measurements of the trilinear Higgs self-coupling in double Higgs boson events produced at its high-energy stages with collision...
Double Higgs boson production and Higgs self-coupling extraction at CLIC
Abstract The Compact Linear Collider (CLIC) is a future electron–positron collider that will allow measurements of the trilinear Higgs self-coupling in double Higgs boson events produced at its...
Evidence for alternative trapping strategies in two forms of the pitcher plant, Nepenthes rafflesiana.
Nepenthes pitchers are specialized leaves that function as insect traps. Several pitcher components may contribute to trapping, including the pitcher fluid, slippery wax crystals and downward-pointing epidermal cells on the...
Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with alpha4beta1 integrins.
Mariette Vogelezang, Ulrike B Forster, Jaewon Han, Mark H Ginsberg, Charles ffrench-Constant
Jun 16, 2011
Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives.
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune responses to HIV Gag p24 within 3G9 antibody to DEC205 ("DEC-HIV Gag...
Published by: Rockefeller University
Emissions trading with non-signatories in a climate agreement - an analysis of coalition stability
We investigate how different designs of carbon offset mechanisms, like the Kyoto Protocol's Clean Development Mechanism (CDM), affect the success of self-enforcing climate treaties. In a game-theoretic numerical model of...
Emissions trading with non-signatories in a climate agreement - an analysis of coalition stability
We investigate how different designs of carbon offset mechanisms, like the Kyoto Protocol's Clean Development Mechanism (CDM), affect the success of self-enforcing climate treaties. In a game-theoretic numerical model of...
How to catch more prey with less effective traps
Carnivorous Nepenthes pitcher plants capture arthropods with specialized slippery surfaces. The key trapping surface, the pitcher rim (peristome), is highly slippery when wetted by rain, nectar or condensation, but not when dry....
With a flick of the lid
Carnivorous pitcher plants capture prey with modified leaves (pitchers), using diverse mechanisms such as 'insect aquaplaning' on the wet pitcher rim, slippery wax crystals on the inner pitcher wall, and viscoelastic retentive...
Unraveling the kinetochore nanostructure in Schizosaccharomyces pombe using multi-color SMLM imaging.
David Virant, Ilijana Vojnovic, Jannik Winkelmeier, Marc Endesfelder, Bartosz Turkowyd, David Lando, Ulrike Endesfelder
Feb 26, 2023
Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients.
Heike Kölbel, Denisa Hathazi, Matthew Jennings, Rita Horvath, Andreas Roos, Ulrike Schara
May 28, 2019
Laminin-211 deficiency leads to the most common form of congenital muscular dystrophy in childhood, MDC1A. The clinical picture is characterized by severe muscle weakness, brain abnormalities and delayed motor milestones...
Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes
Ulrike Schierloh, Malgorzata E Wilinska, Ineke M Pit-Ten Cate, Petra Baumann, Roman Hovorka, Carine de Beaufort, Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management
Mar 11, 2019
BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1...
MicroRNA targets in Drosophila.
BACKGROUND: The recent discoveries of microRNA (miRNA) genes and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have set the stage for elucidation of a...
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry Taylor, Michael Danson, Peter Schönheit, Susan Crennell
Jul 03, 2018
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these...
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry Taylor, Michael Danson, Peter Schönheit, Susan Crennell
Jul 03, 2018
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these...
Mitochondrial and nuclear disease panel (Mito-aND-Panel)
Angela Abicht, Florentine Scharf, Stephanie Kleinle, Ulrike Schön, Elke Holinski-Feder, Rita Horvath, Anna Benet-Pagès, Isabel Diebold
Mar 07, 2019
BACKGROUND: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a robust high-throughput...
NUMTs heteroplasmy detection high-throughput sequencing mitochondrial and nuclear disease panel mitochondrial disorders mtDNA-server Costs and Cost Analysis DNA Mitochondrial Genetic Testing High-Throughput Nucleotide Sequencing Humans Mitochondrial Diseases Sensitivity and Specificity Sequence Analysis DNA
Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency.
Veronika Boczonadi, Paul M Smith, Angela Pyle, Aurora Gomez-Duran, Ulrike Schara, Mar Tulinius, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
Childhood-onset mitochondrial encephalomyopathies are severe, relentlessly progressive conditions. However, reversible infantile respiratory chain deficiency (RIRCD), due to a homoplasmic mt-tRNA(Glu) mutation, and reversible...
Social work support and unmet social needs in life after stroke
Sophie Lehnerer, Benjamin Hotter, Inken Padberg, Petra Knispel, Dike Remstedt, Andrea Liebenau, Ulrike Grittner, Ian Wellwood, Andreas Meisel, BSA Long Term Care Study Group
Sep 05, 2020
BACKGROUND: Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to work...
Assessment tools Long-Term Care Screening social work Social situation stroke Unmet social needs Aged Aged 80 and over Caregivers Cross-Sectional Studies Disabled Persons Female Humans Long-Term Care Male Middle Aged Patient Discharge Quality of life Retrospective Studies social support Social Work stroke Stroke Rehabilitation Surveys and Questionnaires Survivors
Anticaries and antimicrobial activities of methanolic extract from leaves of <i>Cleistocalyx operculatus</i> L.
Phuong Thi Mai Nguyen, Nadin Schultze, Christian Boger, Zeyad Alresley, Albert Bolhuis, Ulrike Lindequist
Jan 01, 2017
Objective: To investigate antimicrobial activities of methanolic extract of leaves of Cleistocalyx operculatus L. (C. operculatus) grown in Vietnam.
Methods: The methanolic extract of C. operculatus leaves was...
Methods: The methanolic extract of C. operculatus leaves was...
Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation.
Liliya Euro, Svetlana Konovalova, Jorge Asin-Cayuela, Már Tulinius, Helen Griffin, Rita Horvath, Robert W Taylor, Patrick F Chinnery, Ulrike Schara, David R Thorburn, Anu Suomalainen, Joseph Chihade, Henna Tyynismaa
Mar 07, 2019
The accuracy of mitochondrial protein synthesis is dependent on the coordinated action of nuclear-encoded mitochondrial aminoacyl-tRNA synthetases (mtARSs) and the mitochondrial DNA-encoded tRNAs. The recent advances in...
Variability of the mechanical properties of hemp concrete
Cesar Niyigena, Sofiane Amziane, Alaa Chateauneuf, Laurent Arnaud, Leticia Bessette, Florence Collet, Christophe Lanos, Gilles Escadeillas, Mike Lawrence, Camille Magniont, Sandrine Marceau, Sara Pavia, Ulrike Peter, Vincent Picandet, Mohammed Sonebi, Peter Walker
Jun 01, 2016
The focus of this study is on statistical analysis of hemp concrete properties. The main objective is to determine statistically the variability of the three main properties, which are: material density, compressive strength and...
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