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Z-DNA and Z-RNA are functionally important left-handed structures of nucleic acids, which play a significant role in several molecular and biological processes including DNA replication, gene expression regulation and viral...

Z-DNA Z-RNA Zα domain Bioinformatics Protein Binding Amino Acid Sequence Binding Sites DNA Z-Form DNA-Binding Proteins Models Molecular Molecular Docking Simulation Molecular Dynamics Simulation Nucleic Acid Conformation Protein Binding Protein Conformation Protein Interaction Domains and Motifs RNA RNA-Binding Proteins Structure-Activity Relationship

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal...

Dimerization ErbB Receptors Fluorescence Resonance Energy Transfer HEK293 Cells Humans Intercellular Signaling Peptides and Proteins Phosphorylation Protein Conformation

Amino Acids Amino Acyl-tRNA Synthetases Animals Brain Gene Expression Regulation Enzymologic Mice Neuroglia Neurons Proteome RNA Transfer

Compensating in flow cytometry is an unavoidable challenge in the data analysis of fluorescence-based flow cytometry. Even the advent of spectral cytometry cannot circumvent the spillover problem, with spectral unmixing an...

Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among...

ancient DNA paleo virology parvovirus B19 Virology virus evolution Erythema Infectiosum evolution Molecular Genome Viral Genotype History 19th Century History 20th Century Humans Parvovirus B19 Human Phylogeny Sequence Analysis DNA

Africa Animals Asia Europe evolution Molecular Genotype Hepatitis B Hepatitis B virus History Ancient History Medieval Hominidae Human Migration Humans Phylogeny Recombination Genetic

Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we...

Animals Binding Sites CCCTC-Binding Factor Chromosomes evolution Molecular Genome Karyotyping Long Interspersed Nucleotide Elements Mice Muridae Phylogeny Retroelements Species Specificity

For thousands of years the Eurasian steppes have been a centre of human migrations and cultural change. Here we sequence the genomes of 137 ancient humans (about 1× average coverage), covering a period of 4,000 years, to...

Asia Asian People Europe Farmers Genome Human grassland History Ancient Human Migration Humans Phylogeny White People