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Effects of Cannabis Use on the Protein and Lipid Profile of Olfactory Neuroepithelium Cells from Schizophrenia Patients Studied by Synchrotron-Based FTIR Spectroscopy.
Sergi Saladrigas-Manjón, Tanja Dučić, Liliana Galindo, Cristina Fernández-Avilés, Víctor Pérez, Rafael de la Torre, Patricia Robledo
Feb 20, 2020
Schizophrenia (SCZ) is a neurodevelopmental disorder with a high genetic component, but the presence of environmental stressors can be important for its onset and progression. Cannabis use can be a major risk factor for...
Multidimensional predictors of negative symptoms in antipsychotic-naive first-episode psychosis.
Alba Toll, Laura Blanco-Hinojo, Daniel Bergé, Xavier Duran, Irene Canosa, Teresa Legido, Federico Marmol, Víctor Pérez-Solà, Emilio Fernández-Egea, Anna Mané
Feb 20, 2022
BACKGROUND: Despite a large body of schizophrenia research, we still have no reliable predictors to guide treatment from illness onset. The present study aimed to identify baseline clinical or neurobiological factors - including...
Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients.
Marta Barrera-Conde, Karina Ausin, Mercedes Lachén-Montes, Joaquín Fernández-Irigoyen, Liliana Galindo, Aida Cuenca-Royo, Cristina Fernández-Avilés, Víctor Pérez, Rafael de la Torre, Enrique Santamaría, Patricia Robledo
Feb 26, 2021
A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory...
RAD51D Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Jul 08, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the splicing...
<i>RAD51D</i> Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike P G Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Aug 02, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the...
Breast Cancer ovarian cancer susceptibility genes ESE ESS VUS aberrant splicing minigene RAD51D clinical interpretation
Published by: Cancers
Use of Blumensaat's line for assessment of cranial tibial subluxation in dogs with cranial cruciate ligament deficiency
Sebastian Prior, Francisco Silveira, Lida Pappa, Pablo Pérez López, Robert Quinn, Darren Barnes
Apr 23, 2022
Abstract: Background: This study aimed to determine whether Blumensaat's line, a consistently present radiographic feature delineating the peak of the femoral intercondylar fossa, could be used to assess for cranial tibial...
Minigene-based splicing analysis and ACMG/AMP-based tentative classification of 56 ATM variants.
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Ada Esteban-Sánchez, Víctor Lorca, Inés Llinares-Burguet, Jamie Allen, Alicia García-Álvarez, Pedro Pérez-Segura, Mercedes Durán, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco-Sampedro
Jul 15, 2022
The ataxia telangiectasia-mutated (ATM) protein is a major coordinator of the DNA damage response pathway. ATM loss-of-function variants are associated with 2-fold increased breast cancer risk. We aimed at identifying and...
Splicing predictions, minigene analyses, and ACMG-AMP clinical classification of 42 germline PALB2 splice-site variants.
Alberto Valenzuela-Palomo, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Víctor Lorca, Eugenia Fraile-Bethencourt, Ada Esteban-Sánchez, Susana Gómez-Barrero, Sara Carvalho, Jamie Allen, Alicia García-Álvarez, Pedro Pérez-Segura, Leila Dorling, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Jan 07, 2022
PALB2 loss-of-function variants confer high risk of developing breast cancer. Here we present a systematic functional analysis of PALB2 splice-site variants detected in approximately 113,000 women in the large-scale sequencing...
PALB2 VUS aberrant splicing Breast Cancer clinical interpretation functional assay minigene splicing susceptibility genes Alternative Splicing Biomarkers Tumor Breast Neoplasms Case-Control Studies Databases Genetic Exons Fanconi Anemia Complementation Group N Protein Female Humans MCF-7 Cells Protein Isoforms RNA Splice Sites
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
Pooja Gupta, Sherine E Thomas, Shaymaa A Zaidan, Maria A Pasillas, James Cory-Wright, Víctor Sebastián-Pérez, Ailidh Burgess, Emma Cattermole, Clio Meghir, Chris Abell, Anthony G Coyne, William R Jacobs, Tom L Blundell, Sangeeta Tiwari, Vítor Mendes
Sep 02, 2021
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in...
Study on the Effects of Size-Shape Parameter Variation of Exothermic Riser Sleeves and Its Influence on Temperature Dependent Parameters
Using exothermic sleeves allows to reduce the volume of the risers required in the casting of ferrous alloys, as well as the amount of metal used, and the costs involved. In this work, flat plates of nodular iron were casted and...
Published by: IGI Global Scientific Publishing
RAD51D Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F. Easton, Peter Devilee, Maaike P. G. Vreeswijk, Miguel de la Hoya, Eladio A. Velasco
Jun 08, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the splicing...
C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation
Bettina Meier, Nadezda V. Volkova, Bin Wang, Víctor González-Huici, Simone Bertolini, Peter J. Campbell, Moritz Gerstung, Anton Gartner
Oct 06, 2021
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution...
The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation.
M Rosario Ramírez-Flores, Sergio Perez-Limon, Meng Li, Benjamín Barrales-Gamez, Doris Albinsky, Uta Paszkowski, Víctor Olalde-Portugal, Ruairidh Jh Sawers
Jan 25, 2021
Arbuscular mycorrhizal fungi (AMF) are ubiquitous in cultivated soils, forming symbiotic relationships with the roots of major crop species. Studies in controlled conditions have demonstrated the potential of AMF to enhance the...
Identifying a living great-grandson of the Lakota Sioux leader Tatanka Iyotake (Sitting Bull).
Ida Moltke, Thorfinn Sand Korneliussen, Andaine Seguin-Orlando, J Víctor Moreno-Mayar, Ernie LaPointe, William Billeck, Eske Willerslev
Jan 06, 2022
A great-grandson of the legendary Lakota Sioux leader Sitting Bull (Tatanka Iyotake), Ernie LaPointe, wished to have their familial relationship confirmed via genetic analysis, in part, to help settle concerns over Sitting...
Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.
Tiago Rodrigues, Florian Sieglitz, Víctor J Somovilla, Pedro MSD Cal, Antony Galione, Francisco Corzana, Gonçalo JL Bernardes
Jul 06, 2016
Oxidation triggers guest dissociation during reorganization of an FeII 4L6 twisted parallelogram.
Alex J Plajer, Felix J Rizzuto, Larissa KS von Krbek, Yohan Gisbert, Víctor Martínez-Agramunt, Jonathan R Nitschke
Jul 28, 2021
A three-dimensional FeII 4L6 parallelogram was prepared from ferrocene-containing ditopic ligands. The steric preference of the bulky ferrocene cores towards meridional vertex coordination brought about this new structure type...
Brain-to-Brain Coupling in the Gamma-Band as a Marker of Shared Intentionality
Cooperation and competition are two ways of social interaction keys to life in society. Recent EEG-based hyperscanning studies reveal that cooperative and competitive interactions induce an increase in interbrain coupling....
Joint recording of EEG and audio signals in hyperscanning and pseudo-hyperscanning experiments.
Hyperscanning is an emerging technique that allows for the study of brain similarities between interacting individuals. This methodology has powerful implications for understanding the neural basis of joint actions, such as...
The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation
M Rosario Ramírez-Flores, Sergio Perez-Limon, Meng Li, Benjamín Barrales-Gamez, Doris Albinsky, Uta Paszkowski, Víctor Olalde-Portugal, Ruairidh Jh Sawers
Nov 20, 2020
Arbuscular mycorrhizal fungi (AMF) are ubiquitous in cultivated soils, forming symbiotic relationships with the roots of major crop species. Studies in controlled conditions have demonstrated the potential of AMF to enhance the...
C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation.
Bettina Meier, Nadezda V Volkova, Bin Wang, Víctor González-Huici, Simone Bertolini, Peter J Campbell, Moritz Gerstung, Anton Gartner
Nov 06, 2021
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution...
Occupation times of refracted Lévy processes
A refracted Lévy process is a Lévy process whose dynamics change by subtracting off a fixed linear drift (of suitable size) whenever the aggregate process is above a pre-specified level. More precisely, whenever it exists, a...
Light attenuation in photobioreactors and algal pigmentation under different growth conditions – model identification and complexity assessment
Microalgae are photosynthetic organisms, and thus one of the most important factors affecting their growth is light. Yet, effective design and operation of algal cultivation systems still lacks robust numerical tools. Here, a...
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