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Progression of mouse skin carcinogenesis is associated with increased ERα levels and is repressed by a dominant negative form of ERα.
Stella Logotheti, Dimitra Papaevangeliou, Ioannis Michalopoulos, Maria Sideridou, Katerina Tsimaratou, Ioannis Christodoulou, Katerina Pyrillou, Vassilis Gorgoulis, Spiros Vlahopoulos, Vassilis Zoumpourlis
Oct 03, 2018
Estrogen receptors (ER), namely ERα and ERβ, are hormone-activated transcription factors with an important role in carcinogenesis. In the present study, we aimed at elucidating the implication of ERα in skin cancer, using...
Robust, universal biomarker assay to detect senescent cells in biological specimens.
Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel Muñoz-Espín, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend, Manuel Serrano, Jiri Bartek, Vassilis G Gorgoulis
Apr 16, 2019
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan...
Cellular Senescence
Vassilis Gorgoulis, Peter D Adams, Andrea Alimonti, Dorothy C Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B Maier, Masashi Narita, Laura Niedernhofer, João F Passos, Paul D Robbins, Clemens A Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria
Nov 25, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related...
Social Robots for Pedagogical Rehabilitation
The use of robots as educational learning tools is quite extensive worldwide, yet it is rather limited in special education. In particular, the use of robots in the field of special education is under skepticism since robots are...
Cybernetics Computer Science and Information Technology Network Architecture Science and Engineering
Published by: IGI Global Scientific Publishing
Brightness masking is modulated by disparity structure.
Binocular depth perception Brightness estimation Filling-in Visual masking Adult Analysis of Variance Contrast Sensitivity Female Form Perception Humans Lighting Male Optical Illusions Perceptual Masking Photic Stimulation Psychophysics Sensory Thresholds Vision Disparity Vision Binocular Vision Monocular Young Adult
A game-theoretic optimisation approach to fair customer allocation in oligopolies
Abstract Under the ever-increasing capital intensive environment that contemporary process industries face, oligopolies begin to form in mature markets where a small number of companies regulate...
Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.
ADP-ribosylation factor Rho GTPase SCAR complex type 3 secretion system virulence effector ADP-Ribosylation Factor 1 ADP-Ribosylation Factor 6 ADP-Ribosylation Factors Enteropathogenic Escherichia coli Escherichia coli Proteins HeLa Cells Humans Models Biological Multiprotein Complexes Phagocytosis salmonella Signal Transduction Virulence Factors rac1 GTP-Binding Protein
Hellenism, philhellenism and classical reception
Abstract The Greek Revolution of 1821–1829 mobilized the ideas of classical reception and Philhellenism developed over the previous century to appeal for international support for the war. These...
A game-theoretic optimisation approach to fair customer allocation in oligopolies
Abstract: Under the ever-increasing capital intensive environment that contemporary process industries face, oligopolies begin to form in mature markets where a small number of companies regulate and serve the customer base....
A new microfluidic pressure-controlled Field Effect Transistor (pFET) in digital fluidic switch operation mode
Nikolaos Vourdas, Despina Moschou, Konstantinos Papadopoulos, Dimitrios Davazoglou, Vassilis Stathopoulos
Apr 15, 2018
Lab-on-Chip is currently considered the technology with the potential to revolutionize future biochemical analysis providing miniaturized, low-reagent volume microchips as an alternative to traditional benchtop analysis....
Digital microfluidics Droplet control Droplet logic operations Microfluidic transistor Porous substrate /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3107 name=Atomic and Molecular Physics, and Optics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
A kinase-independent function of PAK is crucial for pathogen-mediated actin remodelling.
The p21-activated kinase (PAK) family regulate a multitude of cellular processes, including actin cytoskeleton remodelling. Numerous bacterial pathogens usurp host signalling pathways that regulate actin reorganisation in order...
Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain.
ATOP THE KADMEIA
Questions were raised in the past regarding the use of Mycenaean tiles as ‘roof tiles’ on the basis of the small numbers of them recovered in excavations and their overall scarcity in Mycenaean domestic contexts. The...
Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily.
MacB is an ABC transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of antibiotics and enterotoxin STII out of the bacterial cell. Here we present the structure of ATP-bound MacB and...
ABC transporter X-ray crystallography tripartite efflux pump ATP-Binding Cassette Transporters Adenosine Triphosphate Aggregatibacter actinomycetemcomitans Bacterial Outer Membrane Proteins Binding Sites Biological Transport Cell Cycle Proteins Crystallography X-Ray Cystic Fibrosis Transmembrane Conductance Regulator Escherichia coli Escherichia coli Proteins Gene Expression Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins Substrate Specificity
Structure of a bacterial toxin-activating acyltransferase.
X-ray crystallography acyl carrier protein acyltransferase hemolysin posttranslational modification Actinobacillus pleuropneumoniae Acyltransferases Amino Acid Sequence Crystallography X-Ray Models Molecular Molecular Sequence Data Protein Conformation Protein Processing Post-Translational Sequence Homology Amino Acid
Antibiotic Resistance Mediated by the MacB ABC Transporter Family
The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram-negative bacteria. Here, we review recent...
Structural basis of lipoprotein recognition by the bacterial Lol trafficking chaperone LolA.
In gram-negative bacteria, lipoproteins are vital structural components of the outer membrane (OM) and crucial elements of machineries central to the physiology of the cell envelope. A dedicated apparatus, the Lol system, is...
ABC transporter Lol lipoprotein trafficking X-ray crystallography antibacterial target protein–lipid interaction Bacterial Outer Membrane Proteins Carrier Proteins Escherichia coli Escherichia coli Proteins Ligands Lipoproteins Models Molecular Molecular Chaperones Periplasm Periplasmic Binding Proteins Protein Structure Tertiary Protein Transport
A new microfluidic pressure-controlled Field Effect Transistor (pFET) in digital fluidic switch operation mode
Nikolaos Vourdas, Despina Moschou, Konstantinos Papadopoulos, Dimitrios Davazoglou, Vassilis Stathopoulos
Apr 15, 2018
Lab-on-Chip is currently considered the technology with the potential to revolutionize future biochemical analysis providing miniaturized, low-reagent volume microchips as an alternative to traditional benchtop analysis....
Digital microfluidics Droplet control Droplet logic operations Microfluidic transistor Porous substrate /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3107 name=Atomic and Molecular Physics, and Optics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
EPEC Recruits a Cdc42-Specific GEF, Frabin, To Facilitate PAK Activation and Host Cell Colonization.
EPEC EspG GTPases actin Cyclic AMP-Dependent Protein Kinases Enteropathogenic Escherichia coli Escherichia coli Infections Guanine Nucleotide Exchange Factors Host-Pathogen Interactions Humans Microfilament Proteins Models Biological Protein Binding Protein Interaction Domains and Motifs Protein Transport cdc42 GTP-Binding Protein
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno.
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno.
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
MACROPHAGES Phagocytosis Actin Cytoskeleton Arf GTPases Wave regulatory complex host–pathogen interplay
Published by: International journal of molecular sciences
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
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