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Results: 42
A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.
Emma L Poole, Verity G Kew, Jonathan CH Lau, Matthew J Murray, Thomas Stamminger, John H Sinclair, Matthew B Reeves
Oct 10, 2018
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML...
Roles of the Default Mode and Multiple-Demand Networks in Naturalistic versus Symbolic Decisions.
The default mode network (DMN) is often associated with representing semantic, social, and situational content of contexts and episodes. The DMN may therefore be important for contextual decision-making, through representing...
The effect of rule retrieval on activity in the default mode network.
The default mode network (DMN) is often associated with internally-directed cognition, distinct from the constraints of the external environment. However, a recent finding is that the DMN shows strong activation after large task...
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
Diego Peretti, Heather L Smith, Nicholas Verity, Ibrahim Humoud, Lis de Weerd, Dean P Swinden, Joseph Hayes, Giovanna R Mallucci
Feb 15, 2021
Increasing levels of the cold-shock protein, RNA-binding motif 3 (RBM3), either through cooling or by ectopic over-expression, prevents synapse and neuronal loss in mouse models of neurodegeneration. To exploit this process...
Becoming Interculturally Adaptable
The prevailing picture of intercultural adaptation among international student sojourners features a reified process of overcoming culture shock or culture-related stress and anxiety. In the context of increasing recruitment of...
Literacy and Language Studies Education Curriculum Development and Instructional Design Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.
Irina Pleines, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, José Ballester-Beltrán, Katja Aurbach, Chiara Lincetto, Rachael M Lane, Galina Schevzov, Warren S Alexander, Douglas J Hilton, William J Astle, Kate Downes, Paquita Nurden, Sarah K Westbury, Andrew D Mumford, Samya G Obaji, Peter W Collins, Fabien Delerue, Lars M Ittner, Nicole S Bryce, Mira Holliday, Christine A Lucas, Edna C Hardeman, Willem H Ouwehand, Peter W Gunning, Ernest Turro, Marloes R Tijssen, Benjamin T Kile
Feb 06, 2017
Collagen fibre implant for tendon and ligament biological augmentation. In vivo study in an ovine model.
Davide Enea, Jessica Gwynne, Simon Kew, Meera Arumugam, Jennifer Shepherd, Roger Brooks, Siddhartha Ghose, Serena Best, Ruth Cameron, Neil Rushton
Apr 19, 2013
PURPOSE: Although most in vitro studies indicate that collagen is a suitable biomaterial for tendon and ligament tissue engineering, in vivo studies of implanted collagen for regeneration of these tissues are still lacking. The...
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Mark Halliday, Helois Radford, Karlijn AM Zents, Collin Molloy, Julie A Moreno, Nicholas C Verity, Ewan Smith, Catharine A Ortori, David A Barrett, Martin Bushell, Giovanna R Mallucci
Nov 16, 2017
See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article.Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis...
cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory
E C Warburton, C P J Glover, Peter V Massey, H Wan, B Johnson, A Bienemann, A Deuschle, J N C Kew, J P Aggleton, Z I Bashir, J Uney, M W Brown
Jul 06, 2005
We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of...
cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory
E C Warburton, C P J Glover, Peter V Massey, H Wan, B Johnson, A Bienemann, A Deuschle, J N C Kew, J P Aggleton, Z I Bashir, J Uney, M W Brown
Jul 06, 2005
We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of...
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A Moreno, Joern R Steinert, Tim Smith, David Dinsdale, Anne E Willis, Giovanna R Mallucci
Nov 09, 2017
In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity. Reduction in synapse number is a consistent early feature of neurodegenerative...
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Heather L Smith, Oliver J Freeman, Adrian J Butcher, Staffan Holmqvist, Ibrahim Humoud, Tobias Schätzl, Daniel T Hughes, Nicholas C Verity, Dean P Swinden, Joseph Hayes, Lis de Weerd, David H Rowitch, Robin Jm Franklin, Giovanna R Mallucci
Nov 28, 2019
Recent interest in astrocyte activation states has raised the fundamental question of how these cells, normally essential for synapse and neuronal maintenance, become pathogenic. Here, we show that activation of the unfolded...
LCN2 PERK signalling astrocyte reactivity state Astrocytes neurodegeneration Neuroprotection secretome synapse translational neuroscience Unfolded Protein Response Animals Astrocytes Endoplasmic reticulum stress Enzyme Inhibitors Eukaryotic Initiation Factor-2B In Vitro Techniques Memory Mice Neurodegenerative Diseases Phosphorylation Prion Diseases Protein Biosynthesis Protein Phosphatase 1 Signal Transduction Synapses Thapsigargin Transcriptome Tunicamycin Unfolded Protein Response eIF-2 Kinase
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS)
Finbar J K O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew A. Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, John P. Osborne
Jan 01, 2017
Background: Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess...
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS)
Finbar J K O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew A. Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, John P. Osborne
Jan 01, 2017
Background: Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess...
Genomics-informed outbreak investigations of SARS-CoV-2 using civet.
Áine O'Toole, Verity Hill, Ben Jackson, Rebecca Dewar, Nikita Sahadeo, Rachel Colquhoun, Stefan Rooke, J T McCrone, Kate Duggan, Martin P McHugh, Samuel M Nicholls, Radoslaw Poplawski, David Aanensen, Matt Holden, Tom Connor, Nick Loman, Ian Goodfellow, Christine V F Carrington, Kate Templeton, Andrew Rambaut
Apr 17, 2023
Published by: PLOS global public health
Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms
Finbar J. K. O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Mario Cortina Borja, Eleanor Hancock, Anthony L Johnson, Colin R Kennedy, Marcus Likeman, Andrew L Lux, Mark T Mackay, Andrew A Mallick, Richard W Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M Verity, John P. Osborne
Oct 01, 2018
Background: Infantile spasms constitute a severe form of epileptic encephalopathy. In the International Collaborative Infantile Spasms Study (ICISS), we showed that combining vigabatrin with hormonal therapy was more...
The underlying etiology of infantile spasms (West syndrome)
John P. Osborne, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, Finbar J. K. O'Callaghan, on behalf of the participating investigators
Sep 07, 2019
Objective
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms
Finbar J. K. O'Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber, Mario Cortina Borja, Eleanor Hancock, Anthony L Johnson, Colin R Kennedy, Marcus Likeman, Andrew L Lux, Mark T Mackay, Andrew A Mallick, Richard W Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M Verity, John P. Osborne
Oct 01, 2018
Background: Infantile spasms constitute a severe form of epileptic encephalopathy. In the International Collaborative Infantile Spasms Study (ICISS), we showed that combining vigabatrin with hormonal therapy was more...
Climate change increased extreme monsoon rainfall, flooding highly vulnerable communities in Pakistan
Abstract
As a direct consequence of extreme monsoon rainfall throughout the summer 2022 season Pakistan experienced the worst flooding in its history. We employ a probabilistic...
Friederike EL Otto, Mariam Zachariah, Fahad Saeed, Ayesha Siddiqi, Shahzad Kamil, Haris Mushtaq, T Arulalan, Krishna AchutaRao, ST Chaithra, Clair Barnes, Sjoukje Philip, Sarah Kew, Robert Vautard, Gerbrand Koren, Izidine Pinto, Piotr Wolski, Maja Vahlberg, Roop Singh, Julie Arrighi, Maarten van Aalst, Lisa Thalheimer, Emmanuel Raju, Sihan Li, Wenchang Yang, Luke J Harrington, Ben Clarke
Mar 17, 2023
High-throughput total RNA sequencing in single cells using VASA-seq.
Fredrik Salmen, Joachim De Jonghe, Tomasz S Kaminski, Anna Alemany, Guillermo E Parada, Joe Verity-Legg, Ayaka Yanagida, Timo N Kohler, Nicholas Battich, Floris van den Brekel, Anna L Ellermann, Alfonso Martinez Arias, Jennifer Nichols, Martin Hemberg, Florian Hollfelder, Alexander van Oudenaarden
Dec 15, 2022
Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes the detection of many long non-coding...
Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool.
Áine O'Toole, Emily Scher, Anthony Underwood, Ben Jackson, Verity Hill, John T McCrone, Rachel Colquhoun, Chris Ruis, Khalil Abu-Dahab, Ben Taylor, Corin Yeats, Louis du Plessis, Daniel Maloney, Nathan Medd, Stephen W Attwood, David M Aanensen, Edward C Holmes, Oliver G Pybus, Andrew Rambaut
Oct 18, 2021
The underlying etiology of infantile spasms (West syndrome)
John P. Osborne, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, Finbar J. K. O'Callaghan, on behalf of the participating investigators
Sep 07, 2019
Objective
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
To determine the underlying etiologies in a contemporary cohort of infants with infantile spasms and to examine response to treatment.
Methods
Identification of the underlying etiology and...
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