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Results: 79
Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy.
K Kozusko, Vhm Tsang, W Bottomley, YH Cho, S Gandotra, ML Mimmack, K Lim, I Isaac, Satish Patel, V Saudek, S O'Rahilly, S Srinivasan, JR Greenfield, I Barroso, LV Campbell, DB Savage
May 27, 2016
1-Acylglycerol-3-Phosphate O-Acyltransferase 3T3-L1 Cells Adipocytes White Adolescent Adult Amino Acid Sequence Animals Base Sequence Carrier Proteins Diabetes mellitus Type 2 Family Health Female Frameshift Mutation Humans Hyperlipoproteinemia Type IV Insulin Resistance lipodystrophy Familial Partial Male Mice Middle Aged Molecular Sequence Data Mutagenesis Site-Directed Pedigree Perilipin-1 Phosphoproteins
Traversable acausal retrograde domains in spacetime
In this paper we present geometry which has been designed to fit a layperson's description of a 'time machine'. It is a box which allows those within it to travel backwards and forwards through time and space, as interpreted by...
Dendritic cells cross-present latency gene products from Epstein-Barr virus-transformed B cells and expand tumor-reactive CD8+ killer T cells
Dendritic cells (DCs) are not targets for infection by the transforming Epstein-Barr virus (EBV). To test if the adjuvant role of DCs could be harnessed against EBV latency genes by cross-presentation, DCs were allowed to...
Published by: Rockefeller University
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function
The Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA1) maintains the viral episome in all host cells infected with EBV. Recently, EBNA1 was found to be the main EBV latency antigen for CD4+ T cells and could be recognized in...
cell isolation Epstein Barr virus nasopharynx carcinoma T lymphocyte subpopulation virus carcinogenesis
Published by: Rockefeller University
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
During the innate response to many inflammatory and infectious stimuli, dendritic cells (DCs) undergo a differentiation process termed maturation. Mature DCs activate antigen-specific naive T cells. Here we show that both...
antigen expression dendritic cell cytokine release interleukin 2 Immunoregulation Signal Transduction
Published by: Rockefeller University
Normalizing and denoising protein expression data from droplet-based single cell profiling.
Multimodal single-cell profiling methods that measure protein expression with oligo-conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity, yet the resulting protein counts have substantial...
Traversable acausal retrograde domains in spacetime
In this paper we present geometry which has been designed to fit a layperson's description of a 'time machine'. It is a box which allows those within it to travel backwards and forwards through time and space, as interpreted by...
Resonant Shattering Flares as Multimessenger Probes of the Nuclear Symmetry Energy
The behaviour of the nuclear symmetry energy near saturation density is important for our understanding of dense nuclear matter. This density dependence can be parameterised by the nuclear symmetry energy and its derivatives...
Resonant Shattering Flares as Multimessenger Probes of the Nuclear Symmetry Energy
The behaviour of the nuclear symmetry energy near saturation density is important for our understanding of dense nuclear matter. This density dependence can be parameterised by the nuclear symmetry energy and its derivatives...
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
UNLABELLED: The nucleus of the solitary tract (NTS) is emerging as a major site of action for the appetite-suppressive effects of leading pharmacotherapies currently investigated to treat obesity. However, our understanding of...
The Researcher Wellbeing Project Report
Tina Skinner, Kristine Brance, Sarah Halligan, Heather Girling, Paul Chadwick, Emily Tsang
Dec 11, 2023
The Researcher Wellbeing Project (RWP) focused on understanding the potential impacts, including secondary trauma, of researching emotionally challenging topics; and establishing what, if anything, researchers have in place to...
The Researcher Wellbeing Project Report
Tina Skinner, Kristine Brance, Sarah Halligan, Heather Girling, Paul Chadwick, Emily Tsang
Dec 11, 2023
The Researcher Wellbeing Project (RWP) focused on understanding the potential impacts, including secondary trauma, of researching emotionally challenging topics; and establishing what, if anything, researchers have in place to...
Electrode processes at gas | salt | Pd nanoparticle | glassy carbon electrode contacts
Fengjie Xia, Sara E C Dale, Richard A Webster, M Pan, S C Mu, S C Tsang, J M Mitchels, Frank Marken
Jan 01, 0001
The electrochemical oxidation of formic acid to CO(2) is facile at nano-palladium catalysts. In conventional electrochemical systems this process is conducted in aqueous phase and the resulting formation of poorly soluble CO(2)...
Exploring Eco-Innovation Barriers to the Sustainability Transition in Cold Chain E-Fulfilment Systems
The growing demand for cold chain e-fulfilment services has created challenges for implementing low-carbon practices due to the use of extensive energy and insulation materials required to maintain the desired service quality...
Published by: IGI Global Scientific Publishing
Electrode processes at gas | salt | Pd nanoparticle | glassy carbon electrode contacts
Fengjie Xia, Sara E C Dale, Richard A Webster, M Pan, S C Mu, S C Tsang, J M Mitchels, Frank Marken
Jan 01, 0001
The electrochemical oxidation of formic acid to CO(2) is facile at nano-palladium catalysts. In conventional electrochemical systems this process is conducted in aqueous phase and the resulting formation of poorly soluble CO(2)...
Leaves on the line and in the plane
Mathew Penrose
May 05, 2020
The dead leaves model (DLM) provides a random tessellation of $d$-space, representing the visible portions of fallen leaves on the ground when $d=2$. For $d=1$, we establish formulae for the intensity, two-point correlations...
Leaves on the line and in the plane
Mathew Penrose
May 05, 2020
The dead leaves model (DLM) provides a random tessellation of $d$-space, representing the visible portions of fallen leaves on the ground when $d=2$. For $d=1$, we establish formulae for the intensity, two-point correlations...
Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.
Jason CH Tsang, Yong Yu, Shannon Burke, Florian Buettner, Cui Wang, Aleksandra A Kolodziejczyk, Sarah A Teichmann, Liming Lu, Pentao Liu
May 16, 2019
BACKGROUND: Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface...
Intelligent E-Vendor Relationship Management for Enhancing Global B2C E-Commerce Ecosystems
Recently, global e-commerce businesses have been blooming due to the convenience they offer, their product range, and the individualized products and services they offer. To maintain an entire ecosystem, effective...
Published by: IGI Global Scientific Publishing
An End-to-End Bidirectional Authentication System for Pallet Pooling Management Through Blockchain Internet of Things (BIoT)
Pallet pooling is regarded as a sustainable and cost-effective measure for the industry, but challenging to advocate due to weak data and pallet authentication.In order to establish trust between end-users and pallet pooling...
Published by: IGI Global Scientific Publishing
Costs of postoperative morbidity following paediatric cardiac surgery
Emma Hudson, Katherine Brown, Christina Pagel, Jo Wray, David Barron, Warren Rodrigues, Serban Stoica, Shane M Tibby, Victor Tsang, Deborah Ridout, Stephen Morris
May 16, 2020
Objective: Early mortality rates for paediatric cardiac surgery have fallen due to advancements in care. Alternative indicators of care quality are needed. Postoperative morbidities are of particular interest. However, while...
Metabolic changes in schizophrenia and human brain evolution.
Philipp Khaitovich, Helen E Lockstone, Matthew T Wayland, Tsz M Tsang, Samantha D Jayatilaka, Arfu J Guo, Jie Zhou, Mehmet Somel, Laura W Harris, Elaine Holmes, Svante Pääbo, Sabine Bahn
Jun 17, 2011
Structural dynamics of a metal-organic framework induced by CO2 migration in its non-uniform porous structure.
Pu Zhao, Hong Fang, Sanghamitra Mukhopadhyay, Aurelia Li, Svemir Rudić, Ian J McPherson, Chiu C Tang, David Fairen-Jimenez, SC Edman Tsang, Simon AT Redfern
Feb 15, 2019
Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have...
Expanded potential stem cell media as a tool to study human developmental hematopoiesis in vitro.
Adam C Wilkinson, David J Ryan, Iwo Kucinski, Wei Wang, Jian Yang, Sonia Nestorowa, Evangelia Diamanti, Jason Cheuk-Ho Tsang, Juexuan Wang, Lia S Campos, Fengtang Yang, Beiyuan Fu, Nicola Wilson, Pentao Liu, Berthold Gottgens
Jul 16, 2019
Animals Cell Culture Techniques Cell Cycle Cell Lineage Cells Cultured Cellular Reprogramming Techniques Culture Media Embryoid Bodies FIBROBLASTS Genes Reporter Hematopoiesis Human Embryonic Stem Cells Humans Mice Neural Stem Cells Pluripotent Stem Cells Sequence Analysis RNA Species Specificity Stem Cell Transplantation Teratoma
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