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Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm
Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W. chondrophila...
Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm.
Chlamydia trachomatis and Waddlia chondrophila are strict intracellular bacteria belonging to the Chlamydiales order. C. trachomatis is the most frequent bacterial cause of genital and ocular infections whereas W. chondrophila...
The Secretomes of Aspergillus japonicus and Aspergillus terreus Supplement the Rovabio® Enzyme Cocktail for the Degradation of Soybean Meal for Animal Feed.
Delphine Grandmontagne, David Navarro, Virginie Neugnot-Roux, Simon Ladevèze, Jean-Guy Berrin
Apr 08, 2021
One of the challenges of the 21st century will be to feed more than 10 billion people by 2050. In animal feed, one of the promising approaches is to use agriculture by-products such as soybean meal as it represents a rich source...
Analysis of the genetic loci of pigment pattern evolution in vertebrates.
Vertebrate pigmentation patterns are amongst the best characterised model systems for studying the genetic basis of adaptive evolution. The wealth of available data on the genetic basis for pigmentation evolution allows for...
NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I.
Complex I (NADH ubiquinone oxidoreductase) in mammalian mitochondria is an L-shaped assembly of 44 subunits. One arm is embedded in the inner membrane with the other protruding ∼100 Å into the matrix of the organelle. The...
assembly Bioenergetics Complex I Dimethylarginine Electron Transport Methyltransferase Mitochondria Protein Methylation Respiratory chain Arginine Cell Line Tumor Humans Methylation Methyltransferases NADH Dehydrogenase Protein Folding Protein Structure Secondary Protein-Arginine N-Methyltransferases
Brain reactivity to emotion persists in NREM sleep and is associated with individual dream recall.
Maëva Moyne, Guillaume Legendre, Luc Arnal, Samika Kumar, Virginie Sterpenich, Margitta Seeck, Didier Grandjean, Sophie Schwartz, Patrik Vuilleumier, Judith Domínguez-Borràs
Mar 20, 2022
The waking brain efficiently detects emotional signals to promote survival. However, emotion detection during sleep is poorly understood and may be influenced by individual sleep characteristics or neural reactivity. Notably...
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Chrystelle Colas, Sjaak Pouwels, Nicoline Hoogerbrugge, Tanya Bisseling, Virginie Bubien, Frederic Caux, Nathalie Chabbert-Buffet, Sophie Da Mota Gomes, Martin Gotthardt, Marleen Kets, Katherine L. Lachlan, Thera P. Links, Michel Longy, Ritse Mann, Leo Schultze Kool, Robert K. Semple, Ian Stock, Marc Tischkowitz, Janet Vos, Marjolijn Ligtenberg, Rianne Oostenbrink, Rolf Sijmons, Gareth Evans, Emma Woodward, Eamonn Maher, Rosalie E. Ferner, Stefan Aretz, Isabel Spier, Verena Steinke-Lange, Elke Holinski-Feder, Evelin Schröck, Thierry Frebourg, Claude Houdayer, Pierre Wolkenstein, Vincent Bours, Eric Legius, Bruce Poppe, Kathleen Claes, Robin de Putter, Ignacio Blanco Guillermo, Gabriel Capella, Joan Brunet Vidal, Conxi Lázaro, Judith Balmaña, Hector Salvador Hernandez, Carla Oliveira, Manuel Teixeira, Svetlana Bajalica-Lagercrantz, Emma Tham, Jan Lubinski, Karolina Ertmanska, Bela Melegh, Mateja Krajc, Ana Blatnik, Sirkku Peltonen, Marja Hietala
Feb 09, 2021
Abstract: PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial...
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Chrystelle Colas, Sjaak Pouwels, Nicoline Hoogerbrugge, Tanya Bisseling, Virginie Bubien, Frederic Caux, Nathalie Chabbert-Buffet, Sophie Da Mota Gomes, Martin Gotthardt, Marleen Kets, Katherine L. Lachlan, Thera P. Links, Michel Longy, Ritse Mann, Leo Schultze Kool, Robert K. Semple, Ian Stock, Marc Tischkowitz, Janet Vos, Marjolijn Ligtenberg, Rianne Oostenbrink, Rolf Sijmons, Gareth Evans, Emma Woodward, Eamonn Maher, Rosalie E. Ferner, Stefan Aretz, Isabel Spier, Verena Steinke-Lange, Elke Holinski-Feder, Evelin Schröck, Thierry Frebourg, Claude Houdayer, Pierre Wolkenstein, Vincent Bours, Eric Legius, Bruce Poppe, Kathleen Claes, Robin de Putter, Ignacio Blanco Guillermo, Gabriel Capella, Joan Brunet Vidal, Conxi Lázaro, Judith Balmaña, Hector Salvador Hernandez, Carla Oliveira, Manuel Teixeira, Svetlana Bajalica-Lagercrantz, Emma Tham, Jan Lubinski, Karolina Ertmanska, Bela Melegh, Mateja Krajc, Ana Blatnik, Sirkku Peltonen, Marja Hietala
Jun 12, 2021
Abstract: PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial...
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Dec 06, 2019
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers
Pierre Vande Perre, Daniel Toledano, Carole Corsini, Elsa Escriba, Marine Laporte, Helena Bertet, Kevin Yauy, Alain Toledano, Virginie Galibert, Karen Baudry, Lucie Clotet, Elodie Million, Marie-Christine Picot, David Geneviève, Pascal Pujol
Sep 26, 2019
BRCA1 BRCA2 general practitioners genetic screening Hereditary Breast and Ovarian Cancer Syndrome Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Female general practitioners Genetic Carrier Screening Genetic Counseling Health Knowledge Attitudes practice Humans Middle Aged Referral and Consultation
Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.
Robert Adalbert, Stefan Milde, Claire Durrant, Kunie Ando, Virginie Stygelbout, Zehra Yilmaz, Stacey Gould, Jean-Pierre Brion, Michael P Coleman
Jul 04, 2018
Alzheimer's Disease Axonal Transport Aβ FTDP-17T Mitochondria P301L mutation aging Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Axonal Transport Brain Disease Models Animal frontotemporal dementia Genetic Association Studies genetic variation Male Mice Inbred C57BL Mice Transgenic Mitochondria Mutation Plaque Amyloid tau Proteins
Hidden fairy rings and males-Genetic patterns of natural Burgundy truffle (Tuber aestivum Vittad.) populations reveal new insights into its life cycle.
Phylogenomic exploration of the relationships between strains of Mycobacterium avium subspecies paratuberculosis.
Josephine M Bryant, Virginie C Thibault, David GE Smith, Joyce McLuckie, Ian Heron, Iker A Sevilla, Franck Biet, Simon R Harris, Duncan J Maskell, Stephen D Bentley, Julian Parkhill, Karen Stevenson
Sep 29, 2016
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (Map) is an infectious enteric pathogen that causes Johne's disease in livestock. Determining genetic diversity is prerequisite to understanding the epidemiology and...
Impact of climate change on volcanic processes
Thomas J Aubry, Jamie I Farquharson, Colin R Rowell, Sebastian FL Watt, Virginie Pinel, Frances Beckett, John Fasullo, Peter O Hopcroft, David M Pyle, Anja Schmidt, John Staunton Sykes
May 18, 2022
Abstract: The impacts of volcanic eruptions on climate are increasingly well understood, but the mirror question of how climate changes affect volcanic systems and processes, which we term “climate-volcano impacts”, remains...
The fall of the summer truffle
Brian S Steidinger, Ulf Büntgen, Uli Stobbe, Willy Tegel, Ludger Sproll, Matthias Haeni, Barbara Moser, István Bagi, José-Antonio Bonet, Marc Buée, Benjamin Dauphin, Fernando Martínez-Peña, Virginie Molinier, Roman Zweifel, Simon Egli, Martina Peter
Oct 06, 2022
Global warming is pushing populations outside their range of physiological tolerance. According to the environmental envelope framework, the most vulnerable populations occur near the climatic edge of their species'...
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Chrystelle Colas, Sjaak Pouwels, Nicoline Hoogerbrugge, Tanya Bisseling, Virginie Bubien, Frederic Caux, Nathalie Chabbert-Buffet, Sophie Da Mota Gomes, Martin Gotthardt, Marleen Kets, Katherine L. Lachlan, Thera P. Links, Michel Longy, Ritse Mann, Leo Schultze Kool, Robert K. Semple, Ian Stock, Marc Tischkowitz, Janet Vos, Marjolijn Ligtenberg, Rianne Oostenbrink, Rolf Sijmons, Gareth Evans, Emma Woodward, Eamonn Maher, Rosalie E. Ferner, Stefan Aretz, Isabel Spier, Verena Steinke-Lange, Elke Holinski-Feder, Evelin Schröck, Thierry Frebourg, Claude Houdayer, Pierre Wolkenstein, Vincent Bours, Eric Legius, Bruce Poppe, Kathleen Claes, Robin de Putter, Ignacio Blanco Guillermo, Gabriel Capella, Joan Brunet Vidal, Conxi Lázaro, Judith Balmaña, Hector Salvador Hernandez, Carla Oliveira, Manuel Teixeira, Svetlana Bajalica-Lagercrantz, Emma Tham, Jan Lubinski, Karolina Ertmanska, Bela Melegh, Mateja Krajc, Ana Blatnik, Sirkku Peltonen, Marja Hietala
Sep 23, 2020
Abstract: PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial...
Pressure and Chemical Unfolding of an α-Helical Bundle Protein
Cécile Dubois, Vicente J Planelles-Herrero, Camille Tillatte-Tripodi, Stéphane Delbecq, Léa Mammri, Elena M Sirkia, Virginie Ropars, Christian Roumestand, Philippe Barthe
Mar 31, 2021
When combined with NMR spectroscopy, high hydrostatic pressure is an alternative perturbation method used to destabilize globular proteins that has proven to be particularly well suited for exploring the unfolding energy...
NMR high hydrostatic pressure Protein Folding Thermodynamic stability α-helical bundle Adaptor Proteins Signal Transducing Humans Kinetics Magnetic Resonance Spectroscopy Models Molecular Protein Conformation Protein Conformation alpha-Helical Protein Denaturation Protein Domains Protein Unfolding Temperature Thermodynamics
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Nov 03, 2020
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Adenosine Triphosphate Binding Sites Casein Kinase II Catalytic Domain Cell Line Tumor Cell Movement Cell Proliferation Crystallography X-Ray Holoenzymes Humans Kinetics Molecular Docking Simulation Peptides Phosphorylation Protein Kinase Inhibitors Protein Subunits Substrate Specificity Surface Plasmon Resonance
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
Mar 21, 2019
BACKGROUND: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic...
Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.
Lydie Debaize, Hélène Jakobczyk, Stéphane Avner, Jérémie Gaudichon, Anne-Gaëlle Rio, Aurélien A Sérandour, Lena Dorsheimer, Frédéric Chalmel, Jason S Carroll, Martin Zörnig, Michael A Rieger, Olivier Delalande, Gilles Salbert, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec
Apr 25, 2019
Runt-related transcription factor 1 (RUNX1) is a well-known master regulator of hematopoietic lineages but its mechanisms of action are still not fully understood. Here, we found that RUNX1 localizes on active chromatin together...
Animals Antineoplastic Agents Base Sequence Binding Sites Bone Marrow Cells Cell Line Tumor Cell Proliferation Chromatin Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins Enhancer Elements Genetic Gene Expression Regulation Leukemic HEK293 Cells Humans Imatinib Mesylate Mice Mice Inbred NOD Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor Cells B-Lymphoid Primary Cell Culture Protein Binding Proto-Oncogene Proteins c-kit RNA-Binding Proteins Signal Transduction Transcription Genetic Xenograft Model Antitumor Assays
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Amanda K Chaplin, Steven W Hardwick, Antonia Kefala Stavridi, Christopher J Buehl, Noah J Goff, Virginie Ropars, Shikang Liang, Taiana Maia De Oliveira, Dimitri Y Chirgadze, Katheryn Meek, Jean-Baptiste Charbonnier, Tom L Blundell
Jul 12, 2021
DNA Repair DNA-PK NHEJ cryo-EM long-range synaptic complexes Non-homologous end joining Apoptosis Cryoelectron Microscopy DNA Breaks Double-Stranded DNA Damage DNA End-Joining Repair DNA Ligase ATP DNA Repair DNA Repair Enzymes DNA-Activated Protein Kinase DNA-Binding Proteins Humans Ku Autoantigen Multiprotein Complexes Phosphorylation
Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion.
Hana Elasifer, Eddie CY Wang, Virginie Prod'homme, James Davies, Simone Forbes, Richard J Stanton, Mihil Patel, Ceri A Fielding, Dawn Roberts, James A Traherne, Nicole Gruber, Joachim J Bugert, Rebecca J Aicheler, Gavin WG Wilkinson
Jun 17, 2020
Molluscum contagiosum virus (MCV) is a common cause of benign skin lesions in young children and currently the only endemic human poxvirus. Following the infection of primary keratinocytes in the epidermis, MCV induces the...
MHC-I Molluscum contagiosum NK cell T cell Antigen Presentation CD8-Positive T-Lymphocytes Cell Line Down-Regulation Endoplasmic Reticulum Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Immune Evasion Keratinocytes Killer Cells Natural molluscum contagiosum virus T-Lymphocytes Cytotoxic Viral Proteins
Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide
Hélène Jakobczyk, Lydie Debaize, Benoit Soubise, Stéphane Avner, Jérémie Rouger-Gaudichon, Séverine Commet, Yan Jiang, Aurélien A Sérandour, Anne-Gaëlle Rio, Jason S Carroll, Christian Wichmann, Michael Lie-A-Ling, Georges Lacaud, Laurent Corcos, Gilles Salbert, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec
Mar 20, 2021
AML1 CBFA2T3 Childhood Leukemia Driver loop ETO2 inhibitor NHR2 RUNX1 Transcription factor Antineoplastic Agents Cell Line Tumor Child Core Binding Factor Alpha 2 Subunit Gene Expression Regulation Leukemic Humans Peptides Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Protein Interaction Domains and Motifs Protein Interaction Maps Repressor Proteins Transcriptional Activation
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