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Results: 662
Automated identification of Monogeneans using digital image processing and K-nearest neighbour approaches.
BACKGROUND: Monogeneans are flatworms (Platyhelminthes) that are primarily found on gills and skin of fishes. Monogenean parasites have attachment appendages at their haptoral regions that help them to move about the body...
Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.
Dana Wai Yi Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong, Oscar M Rueda, Christopher G Smith, Dineika Chandrananda, Ross A Soo, Hong Liang Lim, Boon Cher Goh, Carlos Caldas, Tim Forshew, Davina Gale, Wei Liu, James Morris, Francesco Marass, Tim Eisen, Tan Min Chin, Nitzan Rosenfeld
Aug 15, 2018
Circulating tumour DNA Liquid biopsy Lung cancer resistance mechanisms targeted therapy Antineoplastic Agents Carcinoma Non-Small-Cell Lung DNA Copy Number Variations DNA Mutational Analysis DNA Neoplasm Drug Resistance Neoplasm ErbB Receptors Gefitinib Humans Hydroxychloroquine Longitudinal Studies Lung Neoplasms Mutation Prognosis Survival Analysis Treatment Outcome Tumor Suppressor Protein p53
Extending the Reach of Quality With CARF Accreditation
Brian Boon
Jan 01, 2022
Accreditation is a common method to assess quality and plan for improvements in the delivery of health and human services. CARF accreditation was established to create standards of quality for specialty programs in...
Published by: IGI Global Scientific Publishing
Observing separate spin and charge Fermi seas in a strongly correlated one-dimensional conductor.
Pedro MT Vianez, Yiqing Jin, María Moreno, Ankita S Anirban, Anne Anthore, Wooi Kiat Tan, Jonathan P Griffiths, Ian Farrer, David A Ritchie, Andrew J Schofield, Oleksandr Tsyplyatyev, Christopher JB Ford
Jul 18, 2022
An electron is usually considered to have only one form of kinetic energy, but could it have more, for its spin and charge, by exciting other electrons? In one dimension (1D), the physics of interacting electrons is captured...
Synergistic Activation of RD29A Via Integration of Salinity Stress and Abscisic Acid in Arabidopsis thaliana.
Plants perceive information from the surroundings and elicit appropriate molecular responses. How plants dynamically respond to combinations of external inputs is yet to be revealed, despite the detailed current knowledge of...
Combined stress Gene expression dynamics mathematical modeling Plant abiotic stresses Signaling cross-talk Abscisic Acid Arabidopsis Arabidopsis Proteins Computer Simulation Gene Expression Profiling Gene Expression Regulation Plant Models Biological Oligonucleotide Array Sequence Analysis Reproducibility of Results salinity Sodium Chloride Stress Physiological
Genetic analysis of wheat sensitivity to the ToxB fungal effector from Pyrenophora tritici-repentis, the causal agent of tan spot
Beatrice Corsi, Lawrence Percival-Alwyn, Rowena C. Downie, Luca Venturini, Elyce M. Iagallo, Camila Campos Mantello, Charlie McCormick-Barnes, Pao Theen See, Richard P. Oliver, Caroline S. Moffat, James Cockram
Jun 06, 2020
Abstract: Key message: Genetic mapping of sensitivity to the Pyrenophora tritici-repentis effector ToxB allowed development of a diagnostic genetic marker, and investigation of wheat pedigrees allowed transmission of sensitive...
Genetic analysis of wheat sensitivity to the ToxB fungal effector from Pyrenophora tritici-repentis, the causal agent of tan spot.
Beatrice Corsi, Lawrence Percival-Alwyn, Rowena C Downie, Luca Venturini, Elyce M Iagallo, Camila Campos Mantello, Charlie McCormick-Barnes, Pao Theen See, Richard P Oliver, Caroline S Moffat, James Cockram
Jan 07, 2021
Genetic mapping of sensitivity to the Pyrenophora tritici-repentis effector ToxB allowed development of a diagnostic genetic marker, and investigation of wheat pedigrees allowed transmission of sensitive alleles to be tracked....
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.
Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel SW Tan, N Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline SJ Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Mar 25, 2021
c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here...
Animals Antineoplastic Agents Carcinoma Squamous Cell Cell Line Tumor Head and Neck Neoplasms Humans Lung Neoplasms Mice Mutation Phenotype Phosphorylation Polymorphism Genetic Prognosis Protein Binding Protein Interaction Domains and Motifs Protein Kinase Inhibitors Proto-Oncogene Proteins c-met Receptor ErbB-2 Signal Transduction Xenograft Model Antitumor Assays
The Grizzly, October 2, 2003
Lindsey Fund, Lauren A. Perotti, Quinn Dinsmore, Alexis Witt, Meg Gallagher, Defne Sarsilmaz, Amanda Bryman, Johanna Nash, Peter Bregman, Trevor Mohr, Monica Delaney, Eden Swick, Crystal McCarney, Marie DiFeliciantonio, Kyle Kauffman, Nicole Beck, Kevin Murphy, Matthew McDermott, Sara Maioli, Kimberly Salmon, Brandie Salenetri, Nicole Frates, Nicole Borocci, Kristen Grimmel, Eddie Murray, Brendan Bell, Aziz Shaikh, Laura Dougherty, Ray Baker
Jan 01, 0001
Sexual Assault Reported on Campus Water Worries Burst in Reimert Senior in the Market for Success Tough Crowd: Bush Speaks to the United Nations Opinions: Out of the Middle East, Part 4; Pharming: The Scariest New Drug Fad;...
Ursinus College Collegeville Pennsylvania newspaper cross country field hockey Football wrestling Volleyball Soccer Bomberger Memorial Hall Campus Activities Board Maples Hall Michael Casey Ernesto Mesinas sexual assault Reimert Hall cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Nanoscale residual stress depth profiling by Focused Ion Beam milling and eigenstrain analysis
AM Korsunsky, E Salvati, AGJ Lunt, Tan Sui, MZ Mughal, R Daniel, J Keckes, E Bemporad, M Sebastiani
Feb 21, 2018
Residual stresses play a crucial role in determining material properties and behaviour, in terms of structural integrity under monotonic and cyclic loading, and for functional performance, in terms of capacitance, conductivity...
Trilepton events and B(s) ---> mu+ mu-
We study the Tevatron search potential for minimal supergravity (mSUGRA) and find
two observables which reveal complementary information on the mSUGRA parameter
space: the “gold-plated” decays of charginos/neutralinos to...
Published by: HEP, Cavendish Laboratory, University of Cambridge
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.
Li Ren Kong, Richard Weijie Ong, Tuan Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, MiYoung Lee, Srinivasaraghavan Kannan, Chandra S Verma, Chwee Ming Lim, Wee Joo Chng, David P Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
May 15, 2020
Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF mechanisms...
Acetylation Animals Antineoplastic Agents Apoptosis Caspase 3 Cell Line Tumor Cell Proliferation cisplatin Codon Epigenesis Genetic Gain of Function Mutation Gene Expression Regulation Neoplastic Humans Hydroxamic Acids Mice SCID Models Biological Mutant Proteins Mutation NF-kappa B Neoplasms Nucleotide Motifs Poly(ADP-ribose) Polymerases Protein Binding Protein Isoforms Sulfonamides Topotecan Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases Xenograft Model Antitumor Assays
Prediction and identification of synergistic compound combinations against pancreatic cancer cells.
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L Bramhall, Tai-Ping Fan, Andreas Bender
Nov 22, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations...
The effect of eigenstrain induced by ion beam damage on the apparent strain relief in FIB-DIC residual stress evaluation
FIB milling using Ga ions is known to be accompanied by implantation, multiplication of material defects, material property modification (e.g. amorphisation), inelastic shrinking/swelling and residual stress generation. These...
The Grizzly, February 26, 1991
Krishni Patrick, Sara Jacobson, Dawn Deraney, Erika Compton, Terri Johnson, Chris Major, Jennifer Strawbridge, Danielle Owens, Tonya Ugoretz, Laura Zobel, Judd Woytek, Christin Outwin, Eleanore Hajian, Gina Solensky, Richard P. Richter, Antoni Castells-Talens, Neil Schafer
Jan 01, 0001
The Gulf War: How Will It Affect the Economy? Airband Competition Enters Its Eighth Year Sears-Roebuck Award, A Boon for Faculty How Will the War End? My First College Field Trip McCabe Wins Contest John Lionarons...
Ursinus College Collegeville Pennsylvania newspaper pre-medical program Chronic fatigue syndrome Olin Hall Wismer Center track team Basketball wrestling Swimming Al Angelos Berman Art Museum campus security Alan McCabe Three Mile Island Nicholas Berry Gulf War student government Air Band cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Mathematical modelling of genipin-bovine serum albumin interaction using fluorescence intensity measurements
Djurdja Vukajlovic, Rory Timmons, Stevan Macesic, John Sanderson, Fengwei Xie, Tarek M. Abdelghany, Emma Smith, Wing Man Lau, Keng Wooi Ng, Katarina Novakovic
Sep 30, 2024
The interaction between genipin and a model protein bovine serum albumin (BSA), with and without the addition of acetic acid, has been studied experimentally and by modelling. The number of amino groups available to react was...
Effect of Pt deposition on digital image correlation analysis for residual stress measurement using FIB-DIC ringcore method
Hongjia Zhang, Enrico Salvati, Siqi Ying, Alexander Lunt, Tan Sui, Alexander M. Korsunsky
Jan 01, 2016
FIB-DIC ringcore milling is an attractive semi-destructive method of measuring microscopic residual stress. Ensuring the accuracy and reliability of DIC analysis of sample surface deformation is critical for correct stress...
Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell
Jun 29, 2018
Combination of cytotoxic therapy with emerging DNA damage response inhibitors (DDRi) has been limited by tolerability issues. However, the goal of most combination trials has been to administer DDRi with standard-of-care doses...
Animals Antineoplastic Combined Chemotherapy Protocols Cell Cycle Proteins Cell Line Tumor Cell Proliferation Checkpoint Kinase 1 DNA Damage DNA Replication Deoxycytidine Drug Synergism Female Humans Mice Mice Inbred BALB C Mice Nude Nuclear Proteins Protein-Tyrosine Kinases Xenograft Model Antitumor Assays Gemcitabine
Fit by adaptation or fit by founding? A comparative study of existing and new entrepreneurial cohorts in China
Extant research provides ambiguous views on the network adaptability of existing ventures and new ventures during environmental change. Applying an institutional perspective, this research aims to provide a clearer picture by...
Effect of Pt deposition on digital image correlation analysis for residual stress measurement using FIB-DIC ringcore method
Hongjia Zhang, Enrico Salvati, Siqi Ying, Alexander Lunt, Tan Sui, Alexander M. Korsunsky
Jan 01, 2016
FIB-DIC ringcore milling is an attractive semi-destructive method of measuring microscopic residual stress. Ensuring the accuracy and reliability of DIC analysis of sample surface deformation is critical for correct stress...
The effect of eigenstrain induced by ion beam damage on the apparent strain relief in FIB-DIC residual stress evaluation
FIB milling using Ga ions is known to be accompanied by implantation, multiplication of material defects, material property modification (e.g. amorphisation), inelastic shrinking/swelling and residual stress generation. These...
Elucidating the Mechanism of Fatigue Crack Acceleration Following the Occurrence of an Underload
Enrico Salvati, Tan Sui, Hongjia Zhang, Alexander J.G. Lunt, Kai Soon Fong, Xu Song, Alexander M. Korsunsky
Dec 01, 2016
Fatigue Crack Growth Rate (FCGR) is altered by a single anomalous load exceeding cyclic maximum (Overload) or compressive load below cyclic minimum (Underload). The authors study fatigue crack acceleration due to a single...
Digital image correlation of 2D X-ray powder diffraction data for lattice strain evaluation
Hongjia Zhang, Tan Sui, Enrico Salvati, Dominik Daisenberger, Alexander J.G. Lunt, Kai Soon Fong, Xu Song, Alexander M. Korsunsky
Mar 15, 2018
High energy 2D X-ray powder diffraction experiments are widely used for lattice strain measurement. The 2D to 1D conversion of diffraction patterns is a necessary step used to prepare the data for full pattern refinement, but...
Digital image correlation of 2D X-ray powder diffraction data for lattice strain evaluation
Hongjia Zhang, Tan Sui, Enrico Salvati, Dominik Daisenberger, Alexander J.G. Lunt, Kai Soon Fong, Xu Song, Alexander M. Korsunsky
Mar 15, 2018
High energy 2D X-ray powder diffraction experiments are widely used for lattice strain measurement. The 2D to 1D conversion of diffraction patterns is a necessary step used to prepare the data for full pattern refinement, but...
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