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Detecting Sequential Genre Change in Eighteenth-Century Texts
Machine classification of historical books into genres is a common task for NLP-based classifiers and has a number of applications, from literary analysis to information retrieval. However it is not a straightforward task, as...
Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic.
Aurélien Mounier, Yann Heuzé, Mathilde Samsel, Sergey Vasilyev, Laurent Klaric, Sébastien Villotte
Dec 22, 2020
Archaeologically defined Upper Palaeolithic (UP, 45,000-10,000 years ago) "cultures" are often used as proxies to designate fossil populations. While recent genomic studies have partly clarified the complex relationship between...
Experimental-Based Laminar Flame Speed Approximation Formulas of Efficiency-Optimized Biofuels for SI-Engine Modeling
Raik Hesse, Christian Schwenzer, Roman Glaznev, Stefania Esposito, Yann Fenard, Heinz Pitsch, Joachim Beeckmann
Sep 16, 2022
The transition towards sustainable mobility encourages research into biofuels for use in internal combustion engines. For these alternative energy carriers, high-fidelity experimental data of flame speeds influenced by...
Structural Classification of Wild Boar (Sus scrofa) Vocalizations.
Maxime Garcia, Bruno Gingras, Daniel L Bowling, Christian T Herbst, Markus Boeckle, Yann Locatelli, W Tecumseh Fitch
Feb 06, 2019
Determining whether a species' vocal communication system is graded or discrete requires definition of its vocal repertoire. In this context, research on domestic pig (Sus scrofa domesticus) vocalizations, for example, has led...
Experimental-Based Laminar Flame Speed Approximation Formulas of Efficiency-Optimized Biofuels for SI-Engine Modeling
Raik Hesse, Christian Schwenzer, Roman Glaznev, Stefania Esposito, Yann Fenard, Heinz Pitsch, Joachim Beeckmann
Sep 16, 2022
The transition towards sustainable mobility encourages research into biofuels for use in internal combustion engines. For these alternative energy carriers, high-fidelity experimental data of flame speeds influenced by...
Buoys with looming eyes deter seaducks and could potentially reduce seabird bycatch in gillnets
Yann Rouxel, Rory Crawford, Ian R. Cleasby, Pete Kibel, Ellie Owen, Veljo Volke, Alexandra K. Schnell, Steffen Oppel
May 05, 2021
Detecting Sequential Genre Change in Eighteenth-Century Texts
Machine classification of historical books into genres is a common task for NLP-based classifiers and has a number of applications, from literary analysis to information retrieval. However it is not a straightforward task, as...
Buoys with looming eyes deter seaducks and could potentially reduce seabird bycatch in gillnets.
Yann Rouxel, Rory Crawford, Ian R Cleasby, Pete Kibel, Ellie Owen, Veljo Volke, Alexandra K Schnell, Steffen Oppel
Jun 13, 2021
Bycatch of seabirds in gillnet fisheries is a global conservation issue with an estimated 400 000 seabirds killed each year. To date, no underwater deterrents trialled have consistently reduced seabird bycatch across operational...
Chronic exposure to glucocorticoids induces suboptimal decision-making in mice.
Lidia Cabeza, Bahrie Ramadan, Julie Giustiniani, Christophe Houdayer, Yann Pellequer, Damien Gabriel, Sylvie Fauconnet, Emmanuel Haffen, Pierre-Yves Risold, Dominique Fellmann, David Belin, Yvan Peterschmitt
Feb 02, 2021
Anxio-depressive symptoms as well as severe cognitive dysfunction including aberrant decision-making (DM) are documented in neuropsychiatric patients with hypercortisolaemia. Yet, the influence of the...
Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell
Jun 29, 2018
Combination of cytotoxic therapy with emerging DNA damage response inhibitors (DDRi) has been limited by tolerability issues. However, the goal of most combination trials has been to administer DDRi with standard-of-care doses...
Animals Antineoplastic Combined Chemotherapy Protocols Cell Cycle Proteins Cell Line Tumor Cell Proliferation Checkpoint Kinase 1 DNA Damage DNA Replication Deoxycytidine Drug Synergism Female Humans Mice Mice Inbred BALB C Mice Nude Nuclear Proteins Protein-Tyrosine Kinases Xenograft Model Antitumor Assays Gemcitabine
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models
Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson, Sandra Bernaldo de Quirós Fernández, Stephen T. Durant, Elaine B. Cadogan, Alan Lau, Frances M. Richards, Duncan I. Jodrell
Oct 27, 2020
Abstract: Background: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR...
The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression.
Yann Wallez, Charles R Dunlop, Timothy Isaac Johnson, Siang-Boon Koh, Chiara Fornari, James WT Yates, Sandra Bernaldo de Quirós Fernández, Alan Lau, Frances M Richards, Duncan I Jodrell
Sep 11, 2018
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, and overall survival rates have barely improved over the past five decades. The antimetabolite gemcitabine remains part of the standard of care but shows...
The CECAM electronic structure library and the modular software development paradigm.
Micael JT Oliveira, Nick Papior, Yann Pouillon, Volker Blum, Emilio Artacho, Damien Caliste, Fabiano Corsetti, Stefano de Gironcoli, Alin M Elena, Alberto García, Víctor M García-Suárez, Luigi Genovese, William P Huhn, Georg Huhs, Sebastian Kokott, Emine Küçükbenli, Ask H Larsen, Alfio Lazzaro, Irina V Lebedeva, Yingzhou Li, David López-Durán, Pablo López-Tarifa, Martin Lüders, Miguel AL Marques, Jan Minar, Stephan Mohr, Arash A Mostofi, Alan O'Cais, Mike C Payne, Thomas Ruh, Daniel GA Smith, José M Soler, David A Strubbe, Nicolas Tancogne-Dejean, Dominic Tildesley, Marc Torrent, Victor Wen-Zhe Yu
Jul 23, 2020
First-principles electronic structure calculations are now accessible to a very large community of users across many disciplines, thanks to many successful software packages, some of which are described in this special issue....
Canadians' opinions towards COVID-19 data-sharing
Sarah A Savic Kallesoe, Tian Rabbani, Erin E Gill, Fiona Brinkman, Emma J Griffiths, Ma'n Zawati, Hanshi Liu, Nicole Palmour, Yann Joly, William W L Hsiao
Mar 13, 2023
Objectives
COVID-19 research has significantly contributed to pandemic response and the enhancement of public health capacity. COVID-19 data collected by provincial/territorial health authorities in Canada are valuable...
Genetics EPIDEMIOLOGY Public Health Health Policy covid-19 Humans Cross-Sectional Studies Public Opinion Canada Pandemics covid-19 COVID-19 Vaccines
Published by: BMJ Open
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models
Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson, Sandra Bernaldo de Quirós Fernández, Stephen T. Durant, Elaine B. Cadogan, Alan Lau, Frances M. Richards, Duncan I. Jodrell
Feb 09, 2021
Abstract: Background: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR...
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models
Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson, Sandra Bernaldo de Quirós Fernández, Stephen T. Durant, Elaine B. Cadogan, Alan Lau, Frances M. Richards, Duncan I. Jodrell
Aug 03, 2021
Abstract: Background: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR...
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach.
Timothy I Johnson, Christopher J Minteer, Daniel Kottmann, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S Carnevalli, Yann Wallez, Alan Lau, Frances M Richards, Duncan I Jodrell
Jul 26, 2021
BACKGROUND: Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis. As a result, cell cycle...
Cancer Cell Cycle Combination treatment high throughput screening synchronisation Cell Culture Techniques Cell Cycle Cell Line Tumor Cell Proliferation Cell Survival Deoxycytidine Drug Screening Assays Antitumor Drug Synergism HeLa Cells High-Throughput Screening Assays Humans MCF-7 Cells Neoplasms Nocodazole Piperazines Pyridines Small Molecule Libraries Time Factors Tubulin Modulators Gemcitabine
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Charles R Dunlop, Yann Wallez, Timothy Isaac Johnson, Sandra Bernaldo de Quirós Fernández, Stephen T Durant, Elaine B Cadogan, Alan Lau, Frances M Richards, Duncan I Jodrell
Jul 01, 2020
Animals Antineoplastic Combined Chemotherapy Protocols Ataxia Telangiectasia Mutated Proteins Carcinoma Pancreatic Ductal Cell Line Tumor Cell Proliferation Deoxycytidine Drug Synergism Female Gene Knockout Techniques Humans Indoles Mice Mice 129 Strain Mice Inbred C57BL Morpholines Pancreatic Neoplasms Pyridines Pyrimidines Quinolines RNA Small Interfering Sulfonamides Sulfoxides Xenograft Model Antitumor Assays Gemcitabine
Canadians' opinions towards COVID-19 data-sharing
Sarah A Savic Kallesoe, Tian Rabbani, Erin E Gill, Fiona Brinkman, Emma J Griffiths, Ma'n Zawati, Hanshi Liu, Nicole Palmour, Yann Joly, William WL Hsiao
Feb 16, 2023
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach.
Timothy I Johnson, Christopher J Minteer, Daniel Kottmann, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S Carnevalli, Yann Wallez, Alan Lau, Frances M Richards, Duncan I Jodrell
Jun 28, 2021
Background
Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis. As a result, cell...
Published by: EBioMedicine
Genetically predicted physical activity levels are associated with lower colorectal cancer risk
Xiaomeng Zhang, Evropi Theodoratou, Xue Li, Susan M Farrington, Philip J Law, Peter Broderick, Marion Walker, Yann C Klimentidis, Jessica MB Rees, Richard S Houlston, Ian PM Tomlinson, Stephen Burgess, Harry Campbell, Malcolm G Dunlop, Maria Timofeeva
Mar 30, 2021
Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer
Jennifer D Brooks, Hermann H Nabi, Irene L Andrulis, Antonis C Antoniou, Jocelyne Chiquette, Philippe Després, Peter Devilee, Michel Dorval, Arnaud Droit, Douglas F Easton, Andrea Eisen, Laurence Eloy, Samantha Fienberg, David Goldgar, Eric Hahnen, Yann Joly, Bartha Maria Knoppers, Aisha Lofters, Jean-Yves Masson, Nicole Mittmann, Jean-Sébastien Paquette, Nora Pashayan, Rita Schmutzler, Tracy Stockley, Sean V Tavtigian, Meghan J Walker, Michael Wolfson, Anna Maria Chiarelli, Jacques Simard
Aug 02, 2021
Early detection of breast cancer through screening reduces breast cancer mortality. The benefits of screening must also be considered within the context of potential harms (e.g., false positives, overdiagnosis). Furthermore...
Published by: Journal of personalized medicine
The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Michal Meir, Yaron Galanty, Lior Kashani, Michael Blank, Rami Khosravi, María Jesús Fernández-Ávila, Andrés Cruz-García, Ayelet Star, Lea Shochot, Yann Thomas, Lisa J Garrett, Daniel A Chamovitz, David M Bodine, Thimo Kurz, Pablo Huertas, Yael Ziv, Yosef Shiloh
Jun 01, 2015
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