A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Hongjun Fu,
Andrea Possenti,
Rosie Freer,
Yoshikazu Nakano,
Nancy C Hernandez Villegas,
Maoping Tang,
Paula VM Cauhy,
Benjamin A Lassus,
Shuo Chen,
Stephanie L Fowler,
Helen Y Figueroa,
Edward D Huey,
Gail Vw Johnson,
Michele Vendruscolo,
Karen E Duff
Jul 26, 2019
Excitatory neurons are preferentially impaired in early Alzheimer's disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place...