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Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid
The pathophysiology of aortic dissection is poorly understood, and its risk is resistant to medical treatment. Most studies have focused on a proposed pathogenic role of transforming growth factor-β in Marfan disease and related...
actin Aneurysm Extracellular Fluid pericyte vasa vasorum aortic dissection Animals Aorta Thoracic Aortic Aneurysm Thoracic Dilatation Pathologic Extracellular Fluid Extracellular Matrix Gene Expression Regulation Genetic Predisposition to Disease Humans Mechanotransduction Cellular Microcirculation Microvessels Models Biological Models Cardiovascular Pressure Vasoconstriction
The CXCL10/CXCR3 Axis and Cardiac Inflammation
Animals Humans Cardiovascular Diseases Inflammation vitamin D Immunoglobulins Intravenous Receptors Lysosphingolipid Interleukin-2 Immunotherapy Signal Transduction T-Lymphocytes Regulatory Chemokine CXCL10 Receptors CXCR3 Chemokine CXCL11
Published by: Journal of immunology research
Sialyltransferase activity and atherosclerosis.
This is the author accepted manuscript. The final version is available from American Heart Association at http://dx.doi.org/10.1161/CIRCRESAHA.114.303480.
NLRP3 inflammasome pathways in atherosclerosis.
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns...
Plan B (-cell) in atherosclerosis.
Atherosclerosis is a leading cause of death worldwide. It is a complex chronic inflammatory disease involving interactions between vascular, circulating and immune cells. B cells play an important role in chronic inflammation...
Monocytes and macrophages in abdominal aortic aneurysm.
Juliette Raffort, Fabien Lareyre, Marc Clément, Réda Hassen-Khodja, Giulia Chinetti, Ziad Mallat
Jun 21, 2018
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical and endovascular repair of AAA have been achieved...
The CANTOS Trial
The results of the CANTOS trial provide exciting evidence in support of the inflammatory hypothesis of atherosclerosis in humans, and is the first phase III clinical trial to show clinical benefit of a targeted anti-inflammatory...
Atherosclerosis Coronary Artery Disease Inflammation Interleukins translational medical research Anti-Inflammatory Agents Antibodies Monoclonal Antibodies Monoclonal Humanized Atherosclerosis Cardiology Clinical Trials Phase III as Topic Coronary Artery Disease Humans Randomized Controlled Trials as Topic Treatment Outcome
PET Imaging of Post-infarct Myocardial Inflammation.
PURPOSE OF REVIEW: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. RECENT FINDINGS: Dysregulated immune responses after myocardial infarction are associated...
Micro-RNAs in abdominal aortic aneurysms
Abdominal aortic aneurysm (AAA) is a major health concern and may be associated with high rates of mortality linked to acute complications. Diagnosis and treatment are, respectively, based on imaging and surgical techniques....
Targeting B cells in atherosclerosis
B lymphocytes B-Cell Activating Factor Antibodies Atherosclerosis belimumab Cardiovascular Diseases Rituximab Animals Atherosclerosis B-Lymphocyte Subsets Disease Models Animal Humans Immunologic Factors Inflammation Mediators Molecular Targeted Therapy Myocardial Infarction Phenotype Signal Transduction Translational Research Biomedical
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
2019 ATVB Plenary Lecture: Interleukin-2 Therapy in Cardiovascular Disease
Regulatory T cells and type-2 innate lymphoid cells represent 2 subsets of immune cells, which have been shown in preclinical models to be important in atherosclerosis and myocardial repair. Regulatory T cells play a crucial...
Vascular smooth muscle cells in atherosclerosis.
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media...
Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients.
Gonzalo J Martínez, Jennifer Y Barraclough, Shirley Nakhla, Vivian Kienzle, Stacy Robertson, Ziad Mallat, David S Celermajer, Sanjay Patel
Jun 21, 2018
To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary...
Acute Coronary Syndromes Microparticles Neutrophils Acute Coronary Syndrome Aged Angina Stable Angioplasty Balloon Coronary Antigens CD Cell Adhesion Molecules Cell-Derived Microparticles Coronary Artery Disease Coronary Circulation Female GPI-Linked Proteins Humans Interleukin-6 Male Middle Aged Neutrophils P-Selectin Peroxidase Plaque Atherosclerotic
IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure.
Rana Ghali, Raffaele Altara, William E Louch, Alessandro Cataliotti, Ziad Mallat, Abdullah Kaplan, Fouad A Zouein, George W Booz
Nov 21, 2018
IL-33 (interleukin 33) is type of cytokine designated an alarmin, which is released under stress conditions or by cell death to induce protective measures in neighboring cells.1 It signals via the ST2 (suppression of...
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