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Results: 22
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.
Mónica Álvarez-Fernández, María Sanz-Flores, Belén Sanz-Castillo, María Salazar-Roa, David Partida, Elisabet Zapatero-Solana, H Raza Ali, Eusebio Manchado, Scott Lowe, Todd VanArsdale, David Shields, Carlos Caldas, Miguel Quintela-Fandino, Marcos Malumbres
Apr 29, 2019
PP2A is a major tumor suppressor whose inactivation is frequently found in a wide spectrum of human tumors. In particular, deletion or epigenetic silencing of genes encoding the B55 family of PP2A regulatory subunits is a common...
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult
Using Diatom and Apicomplexan Models to Study the Heme Pathway of Chromera velia.
Jitka Richtová, Lilach Sheiner, Ansgar Gruber, Shun-Min Yang, Luděk Kořený, Boris Striepen, Miroslav Oborník
Jun 18, 2021
Heme biosynthesis is essential for almost all living organisms. Despite its conserved function, the pathway's enzymes can be located in a remarkable diversity of cellular compartments in different organisms. This location does...
Functional hybrid rubisco enzymes with plant small subunits and algal large subunits
Algal Proteins Arabidopsis Base Sequence Blotting Western Chlamydomonas DNA Complementary Enzyme Stability Gene Expression Regulation Enzymologic Helianthus Kinetics Microscopy Electron Molecular Sequence Data Mutation Photosynthesis Plant Proteins Plasmids Protein Engineering Protein Subunits Recombinant Fusion Proteins Ribulose-Bisphosphate Carboxylase Temperature Transformation Genetic
Differential expression of selected histone modifier genes in human solid cancers.
Hilal Ozdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas
Jun 14, 2011
Breast Neoplasms Carcinoma Cell Transformation Neoplastic Cluster Analysis Colorectal Neoplasms DNA Complementary DNA Neoplasm Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Histone Acetyltransferases Histone Code Histone Deacetylases Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Humans Linear Models Lung Neoplasms Male Neoplasm Proteins Neoplasms Ovarian Neoplasms Pancreatic Neoplasms Polymerase Chain Reaction Polymorphism Single-Stranded Conformational Protein Methyltransferases Protein Processing Post-Translational
Optimising homing endonuclease gene drive performance in a semi-refractory species
Homing endonuclease gene (HEG) drive is a promising insect population control technique that employs meganucleases to impair the fitness of pest populations. Our previous studies showed that HEG drive was more difficult to...
The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle.
Hector Boix-Perales, Ian Horan, Helen Wise, Horng-Ru Lin, Li-Chiou Chuang, P Renee Yew, Anna Philpott
Jun 14, 2011
Animals Cell Cycle Cell Cycle Proteins Cell Differentiation Cell Proliferation Central Nervous System Gene Expression Regulation Developmental Gene Expression Regulation Enzymologic Models Animal Neural Tube Neurons S-Phase Kinase-Associated Proteins Stem Cells Ubiquitin-Protein Ligases Xenopus Proteins Xenopus laevis
Effector gene birth in plant parasitic nematodes
Catherine J Lilley, Abbas Maqbool, Duqing Wu, Hazijah B Yusup, Laura M Jones, Paul RJ Birch, Mark J Banfield, Peter E Urwin, Sebastian Eves-van den Akker
Oct 10, 2018
Plant pathogens and parasites are a major threat to global food security. Plant parasitism has arisen four times independently within the phylum Nematoda, resulting in at least one parasite of every major food crop in the world....
Assembly of the membrane domain of ATP synthase in human mitochondria.
Jiuya He, Holly C Ford, Joe Carroll, Corsten Douglas, Evvia Gonzales, ShuJing Ding, Ian M Fearnley, John E Walker
Apr 13, 2018
The ATP synthase in human mitochondria is a membrane-bound assembly of 29 proteins of 18 kinds. All but two membrane components are encoded in nuclear genes, synthesized on cytoplasmic ribosomes, and imported into the matrix of...
ATP synthase assembly human mitochondria membrane subunits CRISPR-Cas Systems Cell Line Cell Proliferation Gene Expression Regulation Enzymologic Humans Mitochondrial Membranes Mitochondrial Proton-Translocating ATPases Models Molecular Mutation Oxygen Consumption Protein Conformation Protein Subunits
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron
Nov 21, 2019
CHO GCN2 P-stalk Cell Biology Genetics Genomics integrated stress response p1 p2 ribosome stalling ul10 Amino Acids Animals CHO Cells CRISPR-Cas Systems Cricetulus Endoplasmic Reticulum Gene Expression Regulation Enzymologic HeLa Cells Humans Kinetics Ligands Mice Models Molecular Mutagenesis Phosphorylation Protein Binding Protein Conformation Protein Serine-Threonine Kinases Protein Unfolding RNA Transfer Ribosomes Signal Transduction Starvation Transcriptome eIF-2 Kinase
Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity.
Human embryo polarization requires PLC signaling to mediate trophectoderm specification.
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 27, 2021
Cell Biology Cell Polarity developmental biology Human embryo preimplantation Actins Adult Body Patterning Cell Differentiation Cell Lineage Cell Polarity Embryo Culture Techniques Embryo Mammalian Female GATA3 Transcription Factor Gene Expression Regulation Developmental Gene Expression Regulation Enzymologic Humans Phosphoinositide Phospholipase C Phospholipase C beta Pregnancy Signal Transduction Time Factors Young Adult
Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.
Vítor Mendes, Marta Acebrón-García-de-Eulate, Nupur Verma, Michal Blaszczyk, Márcio VB Dias, Tom L Blundell
Nov 07, 2019
ATP synthase from Trypanosoma brucei has an elaborated canonical F1-domain and conventional catalytic sites.
The structures and functions of the components of ATP synthases, especially those subunits involved directly in the catalytic formation of ATP, are widely conserved in metazoans, fungi, eubacteria, and plant chloroplasts. On the...
Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene.
The aminoacyl-tRNA synthetases of Drosophila melanogaster.
CDK6 levels regulate quiescence exit in human hematopoietic stem cells.
Elisa Laurenti, Catherine Frelin, Stephanie Xie, Robin Ferrari, Cyrille F Dunant, Sasan Zandi, Andrea Neumann, Ian Plumb, Sergei Doulatov, Jing Chen, Craig April, Jian-Bing Fan, Norman Iscove, John E Dick
Apr 29, 2015
Generation of an inducible and optimized piggyBac transposon system.
Genomic studies in the mouse have been slowed by the lack of transposon-mediated mutagenesis. However, since the resurrection of Sleeping Beauty (SB), the possibility of performing forward genetics in mice has been reinforced....
Labeling and identifying cell-specific proteomes in the mouse brain.
Toke P Krogager, Russell J Ernst, Thomas S Elliott, Laura Calo, Václav Beránek, Ernesto Ciabatti, Maria Grazia Spillantini, Marco Tripodi, Michael H Hastings, Jason W Chin
Oct 09, 2018
RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases.
Lydia JR Hunter, Samuel F Brockington, Alex M Murphy, Adrienne E Pate, Kristina Gruden, Stuart A MacFarlane, Peter Palukaitis, John P Carr
Feb 26, 2016
Gene Expression Regulation Enzymologic Gene Expression Regulation Plant Host-Pathogen Interactions Plant Diseases Plant Proteins Plants Genetically Modified Potexvirus Potyvirus RNA Interference RNA-Dependent RNA Polymerase Reverse Transcriptase Polymerase Chain Reaction Salicylic Acid Solanum tuberosum Tobacco Mosaic Virus
The DNA polymerases of Drosophila melanogaster.
Steven J Marygold, Helen Attrill, Elena Speretta, Kate Warner, Michele Magrane, Maria Berloco, Sue Cotterill, Mitch McVey, Yikang Rong, Masamitsu Yamaguchi
Jan 09, 2020
DNA synthesis during replication or repair is a fundamental cellular process that is catalyzed by a set of evolutionary conserved polymerases. Despite a large body of research, the DNA polymerases of Drosophila melanogaster have...