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Results: 15
Single cell atlas for 11 non-model mammals, reptiles and birds.
Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Xiran Wang, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai, Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu, Xinghuai Sun, Shenghai Zhang, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu, Yan Hua, Yahong Liu, Huan Liu, Xun Xu
Dec 24, 2021
The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the...
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
An analysis of SARS-CoV-2 cell entry genes identifies the intestine and colorectal cancer as susceptible tissues.
Mahnaz Darvish-Damavandi, James Laycock, Christopher Ward, Milou S van Driel, Mae A Goldgraben, Simon JA Buczacki
Jun 23, 2020
Calicivirus VP2 forms a portal-like assembly following receptor engagement.
Michaela J Conley, Marion McElwee, Liyana Azmi, Mads Gabrielsen, Olwyn Byron, Ian G Goodfellow, David Bhella
Feb 04, 2019
A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells.
BACKGROUND: Host factors required for retroviral infection are potential targets for the modulation of diseases caused by retroviruses. During the retroviral life cycle, numerous cellular factors interact with the virus and play...
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice.
Ralf Salzer, Jordan J Clark, Marina Vaysburd, Veronica T Chang, Anna Albecka, Leo Kiss, Parul Sharma, Andres Gonzalez Llamazares, Anja Kipar, Julian A Hiscox, Andrew Owen, A Radu Aricescu, James P Stewart, Leo C James, Jan Löwe
Aug 26, 2021
The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin-like Dps from hyperthermophilic Sulfolobus islandicus, covalently coupled with SARS-CoV-2...
covid-19 Dps RBD SARS-CoV-2 coronavirus Subunit vaccine Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral Bacterial Proteins covid-19 COVID-19 Vaccines DNA-Binding Proteins Ferritins Humans Immunization Mice Nanoparticles Protein Domains Protein Multimerization Receptors Virus Spike Glycoprotein Coronavirus Sulfolobus
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Thomas L Williams, Gregory Strachan, Robyn GC Macrae, Rhoda E Kuc, Duuamene Nyimanu, Anna L Paterson, Sanjay Sinha, Janet J Maguire, Anthony P Davenport
Jan 05, 2022
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor.
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147....
Antigenic variation of clade 2.1 H5N1 virus is determined by a few amino acid substitutions immediately adjacent to the receptor binding site.
Björn F Koel, Stefan van der Vliet, David F Burke, Theo M Bestebroer, Eny E Bharoto, I Wayan W Yasa, Inna Herliana, Brigitta M Laksono, Kemin Xu, Eugene Skepner, Colin A Russell, Guus F Rimmelzwaan, Daniel R Perez, Albert DME Osterhaus, Derek J Smith, Teguh Y Prajitno, Ron AM Fouchier
Mar 16, 2015
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
Stephanie Bertram, Adeline Heurich, Hayley Lavender, Stefanie Gierer, Simon Danisch, Paula Perin, Jared M Lucas, Peter S Nelson, Stefan Pöhlmann, Elizabeth J Soilleux
Dec 21, 2018
The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host....
Angiotensin-Converting Enzyme 2 Animals Birds Cell Line Disease Reservoirs Enzyme Activation Gastrointestinal Tract Gene Expression Humans Influenza Human Orthomyxoviridae Peptidyl-Dipeptidase A Receptors Virus Respiratory System Severe acute respiratory syndrome-related coronavirus Serine Endopeptidases Severe Acute Respiratory Syndrome Sialic Acids Swine
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Carly GK Ziegler, Samuel J Allon, Sarah K Nyquist, Ian M Mbano, Vincent N Miao, Constantine N Tzouanas, Yuming Cao, Ashraf S Yousif, Julia Bals, Blake M Hauser, Jared Feldman, Christoph Muus, Marc H Wadsworth, Samuel W Kazer, Travis K Hughes, Benjamin Doran, G James Gatter, Marko Vukovic, Faith Taliaferro, Benjamin E Mead, Zhiru Guo, Jennifer P Wang, Delphine Gras, Magali Plaisant, Meshal Ansari, Ilias Angelidis, Heiko Adler, Jennifer MS Sucre, Chase J Taylor, Brian Lin, Avinash Waghray, Vanessa Mitsialis, Daniel F Dwyer, Kathleen M Buchheit, Joshua A Boyce, Nora A Barrett, Tanya M Laidlaw, Shaina L Carroll, Lucrezia Colonna, Victor Tkachev, Christopher W Peterson, Alison Yu, Hengqi Betty Zheng, Hannah P Gideon, Caylin G Winchell, Philana Ling Lin, Colin D Bingle, Scott B Snapper, Jonathan A Kropski, Fabian J Theis, Herbert B Schiller, Laure-Emmanuelle Zaragosi, Pascal Barbry, Alasdair Leslie, Hans-Peter Kiem, JoAnne L Flynn, Sarah M Fortune, Bonnie Berger, Robert W Finberg, Leslie S Kean, Manuel Garber, Aaron G Schmidt, Daniel Lingwood, Alex K Shalek, Jose Ordovas-Montanes, HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org, HCA Lung Biological Network
May 26, 2020
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting...
ACE2 covid-19 ISG SARS-CoV-2 human Influenza interferon MOUSE non-human primate scRNA-seq Adolescent Alveolar Epithelial Cells Angiotensin-Converting Enzyme 2 Animals Betacoronavirus covid-19 Cell Line Cells Cultured Child Coronavirus Infections Enterocytes Goblet Cells HIV Infections Humans Influenza Human Interferon Type I Lung Macaca mulatta Mice Mycobacterium tuberculosis Nasal Mucosa Pandemics Peptidyl-Dipeptidase A Pneumonia Viral Receptors Virus SARS-CoV-2 Serine Endopeptidases Single-Cell Analysis Tuberculosis Up-Regulation
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Teresa Brevini, Mailis Maes, Gwilym J Webb, Binu V John, Claudia D Fuchs, Gustav Buescher, Lu Wang, Chelsea Griffiths, Marnie L Brown, William E Scott, Pehuén Pereyra-Gerber, William Th Gelson, Stephanie Brown, Scott Dillon, Daniele Muraro, Jo Sharp, Megan Neary, Helen Box, Lee Tatham, James Stewart, Paul Curley, Henry Pertinez, Sally Forrest, Petra Mlcochova, Sagar S Varankar, Mahnaz Darvish-Damavandi, Victoria L Mulcahy, Rhoda E Kuc, Thomas L Williams, James A Heslop, Davide Rossetti, Olivia C Tysoe, Vasileios Galanakis, Marta Vila-Gonzalez, Thomas WM Crozier, Johannes Bargehr, Sanjay Sinha, Sara S Upponi, Corrina Fear, Lisa Swift, Kourosh Saeb-Parsy, Susan E Davies, Axel Wester, Hannes Hagström, Espen Melum, Darran Clements, Peter Humphreys, Jo Herriott, Edyta Kijak, Helen Cox, Chloe Bramwell, Anthony Valentijn, Christopher JR Illingworth, UK-PBC Consortium, Bassam Dahman, Dustin R Bastaich, Raphaella D Ferreira, Thomas Marjot, Eleanor Barnes, Andrew M Moon, Alfred S Barritt, Ravindra K Gupta, Stephen Baker, Anthony P Davenport, Gareth Corbett, Vassilis G Gorgoulis, Simon JA Buczacki, Joo-Hyeon Lee, Nicholas J Matheson, Michael Trauner, Andrew J Fisher, Paul Gibbs, Andrew J Butler, Christopher JE Watson, George F Mells, Gordon Dougan, Andrew Owen, Ansgar W Lohse, Ludovic Vallier, Fotios Sampaziotis
Mar 01, 2023
Porcine Sapelovirus Uses α2,3-Linked Sialic Acid on GD1a Ganglioside as a Receptor.
Deok-Song Kim, Kyu-Yeol Son, Kyung-Min Koo, Ji-Yun Kim, Mia Madel Alfajaro, Jun-Gyu Park, Myra Hosmillo, Mahmoud Soliman, Yeong-Bin Baek, Eun-Hyo Cho, Ju-Hwan Lee, Mun-Il Kang, Ian Goodfellow, Kyoung-Oh Cho
Jan 18, 2016
Bacteriophage host range evolution through engineered enrichment bias, exploiting heterologous surface receptor expression.
Research on the initial phage-host interaction has been conducted on a limited repertoire of phages and their cognate receptors, such as phage λ and the Escherichia coli LamB (EcLamB) protein. Apart from phage λ, little is known...