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Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.
Usua Laresgoiti, Marko Z Nikolić, Chandrika Rao, Jane L Brady, Rachel V Richardson, Emma J Batchen, Karen E Chapman, Emma L Rawlins
Oct 05, 2016
Glucocorticoid human Lung development MOUSE STAT3 Adenoviridae Alveolar Epithelial Cells Animals Cell Differentiation Cells Cultured Epithelial Cells Glucocorticoids Humans Lung Mice Mifepristone Pulmonary Alveoli Reverse Transcriptase Polymerase Chain Reaction STAT3 Transcription Factor Signal Transduction Stem Cells
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant.
Jennifer A Dickens, Eimear N Rutherford, Susana Abreu, Joseph E Chambers, Matthew O Ellis, Annemarie van Schadewijk, Pieter S Hiemstra, Stefan J Marciniak
May 17, 2021
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.
Jinwook Choi, Jong-Eun Park, Georgia Tsagkogeorga, Motoko Yanagita, Bon-Kyoung Koo, Namshik Han, Joo-Hyeon Lee
Jun 24, 2020
Developmental Expression and Glucocorticoid Control of the Leptin Receptor in Fetal Ovine Lung.
Miles J De Blasio, Maria Boije, Owen R Vaughan, Brett S Bernstein, Katie L Davies, Alice Plein, Sarah L Kempster, Gordon CS Smith, D Stephen Charnock-Jones, Dominique Blache, FB Peter Wooding, Dino A Giussani, Abigail L Fowden, Alison J Forhead
Aug 11, 2015
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T Bui, Nichelle I Winters, Mei-I Chung, Chitra Joseph, Austin J Gutierrez, Arun C Habermann, Taylor S Adams, Jonas C Schupp, Sergio Poli, Lance M Peter, Chase J Taylor, Jessica B Blackburn, Bradley W Richmond, Andrew G Nicholson, Doris Rassl, William A Wallace, Ivan O Rosas, R Gisli Jenkins, Naftali Kaminski, Jonathan A Kropski, Nicholas E Banovich, Human Cell Atlas Lung Biological Network
Jul 28, 2021
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to...
Alveolar cells in the mammary gland
Christine J Watson
Jun 13, 2022
The mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of...
Alveolar wars
Diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and bronchopulmonary dysplasia injure the gas-exchanging alveoli of the human lung. Animal studies have indicated that dysregulation of...
Mesenchymal Stem Cells Increase Alveolar Differentiation in Lung Progenitor Organoid Cultures.
Lung epithelial cell damage and dysfunctional repair play a role in the development of lung disease. Effective repair likely requires the normal functioning of alveolar stem/progenitor cells. For example, we have shown in a...
Developmental mechanisms and adult stem cells for therapeutic lung regeneration.
Chronic degenerative lung diseases are essentially untreatable pathological conditions. By contrast, the healthy lung has numerous mechanisms that allow for rapid repair and restoration of function following minor acute...
Distal lung epithelial progenitor cell function declines with age.
Julie K Watson, Philip Sanders, Rebecca Dunmore, Guglielmo Rosignoli, Yvon Julé, Emma L Rawlins, Tomas Mustelin, Richard May, Deborah Clarke, Donna K Finch
Jul 07, 2020
Tissue stem cell exhaustion is a key hallmark of aging, and in this study, we characterised its manifestation in the distal lung. We compared the lungs of 3- and 22-month old mice. We examined the gross morphological changes in...
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Carly GK Ziegler, Samuel J Allon, Sarah K Nyquist, Ian M Mbano, Vincent N Miao, Constantine N Tzouanas, Yuming Cao, Ashraf S Yousif, Julia Bals, Blake M Hauser, Jared Feldman, Christoph Muus, Marc H Wadsworth, Samuel W Kazer, Travis K Hughes, Benjamin Doran, G James Gatter, Marko Vukovic, Faith Taliaferro, Benjamin E Mead, Zhiru Guo, Jennifer P Wang, Delphine Gras, Magali Plaisant, Meshal Ansari, Ilias Angelidis, Heiko Adler, Jennifer MS Sucre, Chase J Taylor, Brian Lin, Avinash Waghray, Vanessa Mitsialis, Daniel F Dwyer, Kathleen M Buchheit, Joshua A Boyce, Nora A Barrett, Tanya M Laidlaw, Shaina L Carroll, Lucrezia Colonna, Victor Tkachev, Christopher W Peterson, Alison Yu, Hengqi Betty Zheng, Hannah P Gideon, Caylin G Winchell, Philana Ling Lin, Colin D Bingle, Scott B Snapper, Jonathan A Kropski, Fabian J Theis, Herbert B Schiller, Laure-Emmanuelle Zaragosi, Pascal Barbry, Alasdair Leslie, Hans-Peter Kiem, JoAnne L Flynn, Sarah M Fortune, Bonnie Berger, Robert W Finberg, Leslie S Kean, Manuel Garber, Aaron G Schmidt, Daniel Lingwood, Alex K Shalek, Jose Ordovas-Montanes, HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org, HCA Lung Biological Network
May 26, 2020
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting...
ACE2 covid-19 ISG SARS-CoV-2 human Influenza interferon MOUSE non-human primate scRNA-seq Adolescent Alveolar Epithelial Cells Angiotensin-Converting Enzyme 2 Animals Betacoronavirus covid-19 Cell Line Cells Cultured Child Coronavirus Infections Enterocytes Goblet Cells HIV Infections Humans Influenza Human Interferon Type I Lung Macaca mulatta Mice Mycobacterium tuberculosis Nasal Mucosa Pandemics Peptidyl-Dipeptidase A Pneumonia Viral Receptors Virus SARS-CoV-2 Serine Endopeptidases Single-Cell Analysis Tuberculosis Up-Regulation