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Brain-Derived Neurotrophic Factor Emotional response functional magnetic resonance imaging Major depressive disorder Prefrontal Cortex Striatum Adult Alleles Brain Brain-Derived Neurotrophic Factor Case-Control Studies Depressive Disorder Major Emotions Female Functional Neuroimaging Genotype Humans Magnetic Resonance Imaging Male Middle Aged Polymorphism Single Nucleotide

BNDF Biomarkers Cannabis Psychosis Schizophrenia Adult Age Factors Brain-Derived Neurotrophic Factor Cohort Studies Female Humans Male Marijuana Use Psychotic Disorders Young Adult

BACKGROUND: The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on brain morphology and cognition. Although a met-dose...

BDNF Diffusion Intrinsic curvature MRI Structural Val66met Adolescent Adult Alleles Brain Brain-Derived Neurotrophic Factor Diffusion tensor imaging Female Genotype Heterozygote Homozygote Humans Image Processing Computer-Assisted Male Middle Aged Polymorphism Single Nucleotide Young Adult

The influence of genes and the environment on the development of Post-Traumatic Stress Disorder (PTSD) continues to motivate neuropsychological research, with one consistent focus being the Brain-Derived Neurotrophic Factor...

BDNF Brain-Derived Neurotrophic Factor PSTD Post-traumatic stress disorder allocentric Hippocampus Navigation Spatial Processing trauma trauma processing

Brain-derived neurotrophic factor (BDNF) acting through the tropomyosin-related receptor-B (TrkB) is an important signaling system for the maintenance and survival of neurons. Gene therapy using either recombinant...

adeno-associated viral vector Brain-Derived Neurotrophic Factor gene therapy tropomyosin-related receptor kinase-B Animals Brain-Derived Neurotrophic Factor Dependovirus Genetic Therapy HEK293 Cells Humans Hydrogen Peroxide Ligands Membrane Glycoproteins Mice Neurons Oxidative Stress Phosphorylation Protein Sorting Signals Receptor trkB Retinal Ganglion Cells

Brain-derived neurotrophic factor (BDNF) plays crucial roles in brain function. Numerous studies report alterations in BDNF levels in human serum in various neurological conditions, including mood disorders such as depression....

Fetal Blood serum Placenta Humans Brain-Derived Neurotrophic Factor Anxiety Pregnancy Female Male

Animals Brain-Derived Neurotrophic Factor Chemotaxis Fluorescent Antibody Technique Gene Expression Regulation Growth Cones Humans MicroRNAs Mitogen-Activated Protein Kinase 1 Models Biological Oligonucleotides Antisense Phosphorylation Xenopus Xenopus Proteins

BACKGROUND: Despite a large body of schizophrenia research, we still have no reliable predictors to guide treatment from illness onset. The present study aimed to identify baseline clinical or neurobiological factors - including...

Antipsychotic Agents Brain-Derived Neurotrophic Factor Hippocampus Humans Psychotic Disorders Schizophrenia

Adult Anxiety Brain-Derived Neurotrophic Factor Depressive Disorder Major Female Follow-Up Studies Genetic Predisposition to Disease Humans Hydrocortisone Life Change Events Polymorphism Single Nucleotide Psychiatric Status Rating Scales Saliva

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we...

Animals Anxiety Blood Glucose Brain Brain-Derived Neurotrophic Factor Compulsive Behavior Diabetes mellitus Type 2 Diffusion tensor imaging Disease Models Animal Insulin Insulin-Like Growth Factor I KCNQ1 Potassium Channel Magnetic Resonance Spectroscopy Mice Proteomics Signal Transduction white matter

Aged Aged 80 and over Biomarkers Brain-Derived Neurotrophic Factor Case-Control Studies Cohort Studies Female Humans Mood Disorders Time Tokyo

Increasing levels of the cold-shock protein, RNA-binding motif 3 (RBM3), either through cooling or by ectopic over-expression, prevents synapse and neuronal loss in mouse models of neurodegeneration. To exploit this process...

Animals Biomarkers Brain-Derived Neurotrophic Factor Cold Temperature Membrane Glycoproteins Mice Neuroprotection Phosphorylation Prion Diseases Prions Protein Binding Protein-Tyrosine Kinases Pyramidal Cells RNA-Binding Proteins Signal Transduction Synapses

Animals Axons Brain-Derived Neurotrophic Factor Dependovirus Disease Models Animal Down-Regulation Genetic Therapy Glaucoma HEK293 Cells Humans Intraocular Pressure Male Membrane Glycoproteins Mice Mice Inbred C57BL Neuroprotection Optic Nerve Injuries Rats Rats Sprague-Dawley Receptor trkB Retina Retinal Ganglion Cells Signal Transduction

Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...

Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins

Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic disruption of Bdnf...

Adolescent Brain-Derived Neurotrophic Factor Child Child Preschool Female Hippocampus Humans Male Neurogenesis Neuronal Outgrowth Neurons Phosphorylation Protein Kinases Receptor trkB Signal Transduction

1-Octanol Action Potentials Animals Brain-Derived Neurotrophic Factor Calcium Cluster Analysis Excitatory Postsynaptic Potentials Gap Junctions Models Neurological Posterior Horn Cells Rats

Genetics living systematic review outcome Prognosis Traumatic brain injury Apolipoproteins E Brain Injuries Traumatic Brain-Derived Neurotrophic Factor Cytokines Genetic Association Studies Genome-Wide Association Study Humans Polymorphism Single Nucleotide Treatment Outcome

Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with...

AGRP BDNF Prader-Willi syndrome SNORD116 Hypothalamus obesity Animals Brain-Derived Neurotrophic Factor Fasting Humans Hypothalamus Mice obesity Prader-Willi syndrome Transcriptome

Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during neural wiring, but the full landscape of proteomic changes remains unknown due to limitations in axon sampling and sensitivity. By...

axon Axon guidance chemotropic response extrinsic cues growth cone local protein synthesis neural wiring pSILAC-SP3 Proteomics Retinal ganglion cell Animals Axons Brain-Derived Neurotrophic Factor Cells Cultured Embryo Nonmammalian Gene Expression Regulation Isotope Labeling Mass Spectrometry Netrin-1 Neuronal Outgrowth Proteome Proteomics Retinal Ganglion Cells Semaphorin-3A Xenopus laevis