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Results: 53
A hidden gene in astroviruses encodes a viroporin.
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Olivia JS Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J Savill, Svenja Hester, Sophie Ravel, Jack D Sunter, Camilla Trevor, Steven Rust, Tristan J Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C Taylor, Matthew K Higgins, Mark Carrington
Feb 19, 2020
Structural Characterization of Agonist Binding to an A3 Adenosine Receptor through Biomolecular Simulations and Mutagenesis Experiments.
Dimitrios Stamatis, Panagiotis Lagarias, Kerry Barkan, Eleni Vrontaki, Graham Ladds, Antonios Kolocouris
Oct 04, 2019
Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms.
Chinese hamster ovary (CHO) cells are used for the production of the majority of biopharmaceutical drugs, and thus have remained the standard industry host for the past three decades. The amino acid composition of the medium...
Predicted mouse peroxisome-targeted proteins and their actual subcellular locations.
Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker.
Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Juan Perez, Linda M Hendershot, Heather P Harding, David Ron
Sep 17, 2015
Molecular chaperone Hsp90 is a therapeutic target for noroviruses.
Surender Vashist, Luis Urena, Mariam B Gonzalez-Hernandez, Jayoung Choi, Alexis de Rougemont, Joana Rocha-Pereira, Johan Neyts, Seungmin Hwang, Christiane E Wobus, Ian Goodfellow
Jun 13, 2018
UNLABELLED: Human noroviruses (HuNoV) are a significant cause of acute gastroenteritis in the developed world, and yet our understanding of the molecular pathways involved in norovirus replication and pathogenesis has been...
Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigma.
BACKGROUND: The genus Alphavirus includes several potentially lethal human viruses. Additionally, species such as Sindbis virus and Semliki Forest virus are important vectors for gene therapy, vaccination and cancer research...
Amino Acid Sequence Animals Base Sequence Cell Line Conserved Sequence Cricetinae Fluorescent Antibody Technique Frameshifting Ribosomal Gene Order Immunoprecipitation Isotope Labeling Mass Spectrometry Molecular Sequence Data Nucleic Acid Conformation RNA Viral Semliki forest virus Viral Structural Proteins Virion
A homozygous variant disrupting the PIGH start-codon is associated with developmental delay, epilepsy, and microcephaly.
Alistair T Pagnamenta, Yoshiko Murakami, Consuelo Anzilotti, Hannah Titheradge, Adam J Oates, Jenny Morton, DDD Study, Taroh Kinoshita, Usha Kini, Jenny C Taylor
Feb 07, 2019
Defective glycosylphosphatidylinositol (GPI)-anchor biogenesis can cause a spectrum of predominantly neurological problems. For eight genes critical to this biological process, disease associations are not yet reported. Scanning...
GPI-anchor biogenesis PIGH developmental delay Exome Microcephaly phosphatidylinositol N-acetylglucosaminyltransferase Adolescent Animals Child Child Preschool Codon Initiator Cricetinae Developmental Disabilities Epilepsy Exome Female Glycosylphosphatidylinositols Humans Male Membrane Proteins Microcephaly Mutation Pedigree
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.
Ningguo Gao, Jie Shang, Dang Huynh, Vijaya L Manthati, Carolina Arias, Heather P Harding, Randal J Kaufman, Ian Mohr, David Ron, John R Falck, Mark A Lehrman
Aug 11, 2017
Amides Aminoacridines Animals CHO Cells Congenital Disorders of Glycosylation Cricetinae Dolichol Phosphates Endoplasmic reticulum stress FIBROBLASTS Fluorescent Dyes Glycogen Glycogen Phosphorylase Herpes Simplex Herpesvirus 1 Human Host-Pathogen Interactions Immunity Cellular Indoles Lipopolysaccharides Mannosephosphates Mice Mice Knockout Phosphotransferases (Phosphomutases) Polysaccharides Unfolded Protein Response eIF-2 Kinase
Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.
Aaron G Filler, Garth T Whiteside, Mark Bacon, Martyn Frederickson, Franklyn A Howe, Miri D Rabinowitz, Alan J Sokoloff, Terrence W Deacon, Chris Abell, Raj Munglani, John R Griffiths, B Anthony Bell, Andrew ML Lever
Jun 14, 2011
Amines Analgesics Animals Axonal Transport Cell Line Cells Cultured Cricetinae Cyclohexanecarboxylic Acids Dextrans Dose-Response Relationship Drug Drug Delivery Systems Gabapentin Half-Life Macaca fascicularis Models Neurological Nanoparticles Nerve Growth Factor Neurons Pain Polymers Rabbits Rats Rats Sprague-Dawley Wheat Germ Agglutinins gamma-Aminobutyric Acid
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.
ADP-Ribosylation Factors Animals Autophagy Autophagy-Related Proteins Blotting Western CHO Cells Carrier Proteins Cell Membrane Cricetinae Endocytosis Endoplasmic Reticulum Fluorescent Antibody Technique GTPase-Activating Proteins Golgi Apparatus Green Fluorescent Proteins HeLa Cells Humans Immunosuppressive Agents Phagosomes Phosphatidylinositol 4 5-Diphosphate Phospholipase D Sirolimus TOR Serine-Threonine Kinases
How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Yibin Xu, Nicholas S Kirk, Hariprasad Venugopal, Mai B Margetts, Tristan I Croll, Jarrod J Sandow, Andrew I Webb, Carlie A Delaine, Briony E Forbes, Michael C Lawrence
May 11, 2020
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via...
Cryoelectron Microscopy Insulin-Like Growth Factor I Insulin-Like Growth Factor II leucine zipper single-particle 3D reconstruction type 1 insulin-like growth factor receptor 3T3 Cells Animals Binding Sites CHO Cells Cricetinae Cricetulus Cryoelectron Microscopy Humans Insulin-Like Growth Factor II Mice Molecular Docking Simulation Protein Binding Receptor IGF Type 1
Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition.
Small-cell lung cancer (SCLC) is a particularly aggressive cancer, which metastasises early. Despite initial sensitivity to radio- and chemo-therapy, it invariably relapses, so that the 2-year survival remains less than 5%....
Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.
Adrian J Butcher, Rudi Prihandoko, Kok Choi Kong, Phillip McWilliams, Jennifer M Edwards, Andrew Bottrill, Sharad Mistry, Andrew B Tobin
Aug 20, 2020
G-protein-coupled receptors are hyper-phosphorylated in a process that controls receptor coupling to downstream signaling pathways. The pattern of receptor phosphorylation has been proposed to generate a "bar code" that can be...
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification.
Giovanni Bussotti, Evi Gouzelou, Mariana Côrtes Boité, Ihcen Kherachi, Zoubir Harrat, Naouel Eddaikra, Jeremy C Mottram, Maria Antoniou, Vasiliki Christodoulou, Aymen Bali, Fatma Z Guerfali, Dhafer Laouini, Maowia Mukhtar, Franck Dumetz, Jean-Claude Dujardin, Despina Smirlis, Pierre Lechat, Pascale Pescher, Adil El Hamouchi, Meryem Lemrani, Carmen Chicharro, Ivonne Pamela Llanes-Acevedo, Laura Botana, Israel Cruz, Javier Moreno, Fakhri Jeddi, Karim Aoun, Aïda Bouratbine, Elisa Cupolillo, Gerald F Späth
Apr 12, 2019
Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern Leishmania genomic adaptation....
Leishmania Aneuploidy evolution gene copy number variation genomic adaptation telomeric amplification Adaptation Physiological Animals Chromosomes Cricetinae DNA Copy Number Variations Dogs evolution Molecular Gene Amplification Gene Dosage Gene Expression Regulation Genes Protozoan Genetic Fitness Genome Protozoan Genomics High-Throughput Nucleotide Sequencing Humans Karyotype Leishmania donovani Leishmaniasis Visceral Telomere
New Data on Comparative Cytogenetics of the Mouse-Like Hamsters (Calomyscus Thomas, 1905) from Iran and Turkmenistan.
Svetlana A Romanenko, Vladimir G Malikov, Ahmad Mahmoudi, Feodor N Golenishchev, Natalya A Lemskaya, Jorge C Pereira, Vladimir A Trifonov, Natalia A Serdyukova, Malcolm A Ferguson-Smith, Mansour Aliabadian, Alexander S Graphodatsky
Sep 13, 2021
The taxonomy of the genus Calomyscus remains controversial. According to the latest systematics the genus includes eight species with great karyotypic variation. Here, we studied karyotypes of 14 Calomyscus individuals from...
banding Chromosome Painting fluorescent in situ hybridization Karyotype Molecular cytogenetics painting probes type locality Animals Chromosome Banding Chromosomes Mammalian Cricetinae Cytogenetic Analysis evolution Molecular Heterochromatin In Situ Hybridization Fluorescence Iran Karyotype Mice Phylogeography Species Specificity Synteny Turkmenistan
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells
The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.
Rachael Fletcher, Christopher Gribben, Xiuquan Ma, James G Burchfield, Kristen C Thomas, James R Krycer, David E James, Daniel J Fazakerley
Aug 28, 2020
The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or...
3T3-L1 Cells Adipocytes Androstenes Animals CHO Cells Cricetinae Cricetulus Enzyme Activation Gene Deletion Gene Knockout Techniques Glucose Glucose Transporter Type 4 Insulin Intracellular Signaling Peptides and Proteins Liver X Receptors Mice Niemann-Pick C1 Protein Orphan Nuclear Receptors Phenotype Protein Transport Proteins Proto-Oncogene Proteins c-akt Signal Transduction Transcription Genetic
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical investigation for the treatment of SCLC. As well as acting as a neuropeptide...
Acetylcysteine Animals Antineoplastic Agents Antineoplastic Agents Phytogenic Apoptosis CHO Cells Carcinoma Small Cell Cell Division Cricetinae Drug Synergism Etoposide Free Radical Scavengers Glutathione Growth Inhibitors JNK Mitogen-Activated Protein Kinases Lipid Peroxidation Lung Neoplasms MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases Oligopeptides Oxidation-Reduction Reactive Oxygen Species Stimulation Chemical Transcription Factor AP-1 Transcription Genetic Tumor Cells Cultured
G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.
Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J Clarke, Heather P Harding, Stefan J Marciniak, Randy J Read, David Ron
May 26, 2015
E. coli Biochemistry biophysics cell lines human MOUSE rabbit structural biology Actins Amino Acid Sequence Animals CHO Cells Catalytic Domain Cattle Conserved Sequence Cricetinae Cricetulus Eukaryotic Initiation Factor-2 Humans Mice Models Molecular Molecular Sequence Data Mutation Phosphorylation Protein Phosphatase 1 Rabbits Substrate Specificity
Human artificial chromosome with a conditional centromere for gene delivery and gene expression.
Yuichi Iida, Jung-Hyun Kim, Yasuhiro Kazuki, Hidetoshi Hoshiya, Masato Takiguchi, Masahiro Hayashi, Indri Erliandri, Hee-Sheung Lee, Alex Samoshkin, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina, Vladimir Larionov, Mitsuo Oshimura
Dec 18, 2020
Human artificial chromosomes (HACs), which carry a fully functional centromere and are maintained as a single-copy episome, are not associated with random mutagenesis and offer greater control over expression of ectopic genes on...
Animals CHO Cells Cell Line Centromere Chickens Chromosomes Artificial Human Cricetinae Cricetulus Gene Expression Gene Targeting Gene Transfer Techniques Genetic Therapy Genetic Vectors Green Fluorescent Proteins Humans In Situ Hybridization Fluorescence Operator Regions Genetic Plasmids Polymerase Chain Reaction Recombination Genetic Tetracyclines Transgenes
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.
Thomas L Williams, Robyn GC Macrae, Rhoda E Kuc, Alastair JH Brown, Janet J Maguire, Anthony P Davenport
Mar 23, 2023
Identification of amino acids within norovirus polymerase involved in RNA binding and viral replication.
Kang Rok Han, Bader Y Alhatlani, Sunyoung Cho, Ji-Hye Lee, Myra Hosmillo, Ian G Goodfellow, Kyung Hyun Kim, Jai Myung Yang
Aug 03, 2017
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