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Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ensures...

Amino Acid Motifs Animals Cattle Cell Cycle Proteins Chromosomes Human Computational Biology Enzyme Stability evolution Molecular HeLa Cells Humans Hydrogen-Ion Concentration M Phase Cell Cycle Checkpoints Mice Models Molecular Protein Multimerization Protein Serine-Threonine Kinases Protein Structure Tertiary Protein Transport Protein-Tyrosine Kinases Rats

Algal Proteins Arabidopsis Base Sequence Blotting Western Chlamydomonas DNA Complementary Enzyme Stability Gene Expression Regulation Enzymologic Helianthus Kinetics Microscopy Electron Molecular Sequence Data Mutation Photosynthesis Plant Proteins Plasmids Protein Engineering Protein Subunits Recombinant Fusion Proteins Ribulose-Bisphosphate Carboxylase Temperature Transformation Genetic

Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present acyl substrates to a series of enzyme active sites. Many...

acyl carrier protein Amino Acid Sequence Apoproteins Enzyme Stability Kinetics Magnetic Resonance Spectroscopy Mycobacterium Polyketide Synthases Protein Structure Secondary Protein Structure Tertiary Protein Subunits Solutions Temperature

ERAD S. cerevisiae Biochemistry Cell Biology chemical biology protein degradation protein quality control regulation Endoplasmic Reticulum Endoplasmic Reticulum-Associated Degradation Enzyme Stability Intracellular Membranes Membrane Glycoproteins Protein Domains Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Ubiquitin-Protein Ligases Ubiquitination

Amyloid Enzyme Stability Humans Models Molecular Muramidase Mutation Protein Domains Protein Multimerization Protein Structure Secondary

Animals Binding Sites Catalysis Enzyme Stability Kinetics Luciferases Luciferases Renilla Mammals Mice Molecular Dynamics Simulation Mutagenesis Mutation NIH 3T3 Cells Protein Conformation Protein Engineering Temperature

Wallerian degeneration is delayed when sufficient levels of proteins with NMNAT activity are maintained within axons after injury. This has been proposed to form the basis of 'slow Wallerian degeneration' (Wld (S)), a...

Animals Axons Butadienes Cell Line Enzyme Stability Humans MAP Kinase Kinase 1 MAP Kinase Kinase 2 MAP Kinase Kinase 5 MAP Kinase Signaling System Nicotinamide-Nucleotide Adenylyltransferase Nitriles Phenotype Protein Kinase Inhibitors Rats Superior Cervical Ganglion Wallerian degeneration

Amino Acid Sequence Animals Cattle Chromatography Affinity Enzyme Stability Fungal Proteins fungi Mitochondrial Proton-Translocating ATPases Molecular Sequence Data Pichia Protein Structure Tertiary Protein Subunits Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Sequence Homology Amino Acid Species Specificity Yarrowia

Serum and glucocorticoid-regulated kinase 1 (SGK1) is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL). However, little is known about its function or the consequence of its mutation. The...

Cells Cultured Enzyme Stability Humans Immediate-Early Proteins Lymphoma Large B-Cell Diffuse Phosphorylation Protein Domains Protein Isoforms Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt

Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases is...

ATP-Dependent Proteases Animals Cells Cultured DNA Polymerase gamma DNA Replication DNA Mitochondrial Enzyme Stability HeLa Cells Holoenzymes Humans Mice Mitochondrial Proteins Mutation

Animals Cell Line Enzyme Stability Gene Expression Genes Reporter Hot Temperature Humans Mice Mice Transgenic NIH 3T3 Cells Thermoanaerobacter beta-Galactosidase

Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral protein...

NIH 3T3 Cells Animals Mammals Mice Luciferases Luciferases Renilla Protein Engineering Enzyme Stability Temperature Mutagenesis Binding Sites Protein Conformation Kinetics Mutation Catalysis Molecular Dynamics Simulation

ATF7IP H3K9me3 HUSH complex SETDB1 epigenetic silencing Heterochromatin histone methylation ubiquitin-mediated degradation Cell Nucleus Enzyme Stability Epigenesis Genetic Gene Deletion Gene Silencing HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Proteasome Endopeptidase Complex Protein Binding Protein Methyltransferases Proteolysis Repressor Proteins Transcription Factors Transcriptome

The receptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the control of cellular phosphotyrosine levels. Most human RPTPs possess an extracellular receptor domain and tandem...

Amino Acid Motifs Amino Acid Sequence Biocatalysis Cell Line Disulfides Enzyme Stability Humans Models Molecular Oxidation-Reduction Protein Binding Protein Domains Receptor-Like Protein Tyrosine Phosphatases Class 2 Substrate Specificity

The F-ATPases (also called the F1 Fo -ATPases or ATP synthases) are multi-subunit membrane-bound molecular machines that produce ATP in bacteria and in eukaryotic mitochondria and chloroplasts. The structures and enzymic...

Trypanosoma brucei ATP synthase F1-domain p18-subunit proteolysis of α-subunit subunit composition Adenosine Triphosphate Amino Acid Sequence Computational Biology Conserved Sequence Enzyme Stability Hydrolysis Kinetics Membrane potential Mitochondrial Models Molecular Peptide Mapping Protein Conformation Protein Multimerization Protein Subunits Proteolysis Proton-Translocating ATPases Protozoan Proteins RNA Interference Sequence Alignment Sequence Homology Amino Acid Trypanosoma brucei brucei

Biophysical Phenomena Casein Kinase II Drug Evaluation Preclinical Enzyme Stability Humans Ligands Mutation Protein Multimerization Protein Structure Quaternary Small Molecule Libraries Temperature